Jun 27, 2025; Cleveland, Ohio, USA; St. Louis Cardinals second baseman Brendan Donovan (33) throws to first base in the third inning against the Cleveland Guardians at Progressive Field. Mandatory Credit: David Richard-Imagn Images

Cleveland Guardians vs St. Louis Cardinals Prediction 06/29/2025 Picks

Pick details

St. Louis (46-38) vs Cleveland (40-41)

June 29, 2025 at 12:05 PM EDT

The Line: Betting Odds: Cleveland +107 — Over/Under: +8.5

(Get latest betting odds)

The St. Louis Cardinals and the Cleveland Guardians meet Sunday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a St. Louis Cardinals vs. Cleveland Guardians prediction.

Starting Pitching Matchup

The St. Louis Cardinals will send out Matthew Liberatore for the start here and Liberatore is 5-6 with a 3.96 ERA and 71 strikeouts this season. This will be Liberatore’s second career start against the Guardians. The Cleveland Guardians will send out Logan Allen in this one and Allen is 5-5 with a 4.25 ERA and 54 strikeouts this season. This will be Allen’s first career start against the Cardinals.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to build on their 9-6 win over the Guardians on Saturday to sit at 46-38 on the year. After this series, the Cardinals will head on the road for a division series against the Pittsburgh Pirates.

Cardinals Looking For Another Series Win

Brendan Donovan has a team-high 87 hits along with 21 doubles, 5 home runs and 29 RBIs while Lars Nootbaar has 67 hits with 11 home runs, 35 RBIs, 13 doubles and 4 stolen bases. Nolan Arenado also has 70 hits with 11 doubles, 10 home runs and 39 RBIs of his own and Victor Scott II has 55 hits with 8 doubles, a triple, 24 RBIs and a team-high 22 stolen bases. Willson Contreras has also chipped in 70 hits with 18 doubles, 10 home runs and 50 RBIs of his own as well this season. Masyn Winn’s added 68 points with 14 doubles, 7 home runs and 29 RBIs and Alec Burleson’s added 71 hits with 12 doubles, 9 home runs and 33 RBIs.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to rebound from their loss at the hands of the Cardinals on Saturday to sit at 40-41 on the year. After this series, the Guardians will head on the road for a series against the Chicago Cubs.

Guardians Lose Three In A Row

Steven Kwan has 91 hits as part of a .300 batting average and 6 home runs, 18 doubles and 25 RBIs. Kyle Manzardo has 53 hits with 11 doubles, 2 triples, 13 home runs and 33 RBIs as well this year. Gabriel Arias has 17 doubles but also 88 strikeouts and Manzardo has 69 strikeouts so far this season. Arias has also added 6 home runs and 31 RBIs and Jose Ramirez has chipped in 13 home runs and 38 RBIs. Carlos Santana has also added 61 hits with 9 home runs and 37 RBIs as well this season.

St. Louis Cardinals vs. Cleveland Guardians Prediction

I’m on the Cardinals here. Matthew Liberatore isn’t my favorite option in the Cardinals rotation, but he’s a lefty and the Guardians have been hideous against lefties in a lot of their recent action. The Cardinals are still playing some solid baseball right now and I think they pick up the win in this one. Give me St. Louis.

Chris Ruffolo's Pick: St. Louis -118

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