Your cart is currently empty!

Cleveland Guardians vs St. Louis Cardinals Prediction 06/28/2025 Picks
Pick details
St. Louis (45-38) vs Cleveland (40-40)
June 28, 2025 at 04:10 PM EDT
The Line: Betting Odds: Cleveland -120 — Over/Under: +8.5
The St. Louis Cardinals and the Cleveland Guardians meet Saturday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a St. Louis Cardinals vs. Cleveland Guardians prediction.
Starting Pitching Matchup
The St. Louis Cardinals will send out Miles Mikolas for the start here and Mikolas is 4-5 with a 4.31 ERA and 51 strikeouts this season. In his career, Mikolas is 1-1 with a 2.08 ERA and 10 strikeouts this season. Slade Cecconi will get the start for Cleveland here and is 3-3 with a 3.38 ERA and 37 strikeouts this season. This will be Cecconi’s first career start against the Cardinals.
St. Louis Cardinals Recap
The St. Louis Cardinals come into this game looking to build on their 5-0 win over the Guardians in Friday’s matchup to sit at 45-38 on the year. After this series, the Cardinals will head on the road for a division series against the Pittsburgh Pirates.
Cardinals Looking To Stay Hot
Brendan Donovan has a team-high 87 hits along with 21 doubles, 5 home runs and 29 RBIs while Lars Nootbaar has 67 hits with 11 home runs, 35 RBIs, 13 doubles and 4 stolen bases. Nolan Arenado also has 70 hits with 11 doubles, 10 home runs and 39 RBIs of his own and Victor Scott II has 55 hits with 8 doubles, a triple, 24 RBIs and a team-high 22 stolen bases. Willson Contreras has also chipped in 70 hits with 18 doubles, 10 home runs and 50 RBIs of his own as well this season. Masyn Winn’s added 68 points with 14 doubles, 7 home runs and 29 RBIs and Alec Burleson’s added 71 hits with 12 doubles, 9 home runs and 33 RBIs.
Why the St. Louis Cardinals will win
The Guardians have lost each of their last four games as favorites against National League opponents.
The Cardinals have won each of their last eight Saturday games.
The Cardinals have covered the run line in 12 of their last 13 games as road underdogs.
The Guardians have failed to cover the run line in seven of their last eight games as favorites against National League opponents following a home loss.
St. Louis Cardinals Player Prop Facts
Alec Burleson has hit a home run in four of the Cardinals’ last five road games against AL Central opponents.
Alec Burleson has recorded two or more hits in each of the Cardinals’ last four road games.
Miles Mikolas has recorded four or more strikeouts in six of his last seven appearances with the Cardinals as underdogs.
Cleveland Guardians Recap
The Cleveland Guardians come into this game looking to rebound from their loss at the hands of the Cardinals on Friday to fall to 40-40 on the year. After this series, the Guardians will travel to Wrigley for a series against the Chicago Cubs.
Guardians Shut Out In Back-To-Back Games
Steven Kwan has 90 hits as part of a .306 batting average and 6 home runs, 18 doubles and 24 RBIs. Kyle Manzardo has 51 hits with 11 doubles, 2 triples, 12 home runs and 32 RBIs as well this year. Gabriel Arias has 17 doubles but also 86 strikeouts and Manzardo has 66 strikeouts so far this season. Arias has also added 5 home runs and 29 RBIs and Jose Ramirez has chipped in 13 home runs and 38 RBIs. Carlos Santana has also added 61 hits with 9 home runs and 37 RBIs as well this season.
Why the Cleveland Guardians will win
The Guardians have won each of their last four day games against NL Central opponents following a home loss.
The Cardinals have lost each of their last three games at Progressive Field following a win.
The Guardians have covered the run line in each of their last four day games against NL Central opponents following a home loss.
The Cardinals have failed to cover the run line in five of their last six day games against American League opponents following a win.
Cleveland Guardians Player Prop Facts
Jose Ramirez has hit a home run in three of the Guardians’ last four games as home favorites against NL Central opponents.
Jose Ramirez has recorded two or more hits in four of his last five appearances against the Cardinals.
Jose Ramirez has recorded a Double in three of the Guardians’ last four day games against NL opponents that held a winning record.
Total Runs Facts
Eight of the Guardians’ last nine games after playing the previous day have gone UNDER the total runs line.
Each of the Cardinals’ last four games as underdogs against American League opponents have gone OVER the total runs line.
St. Louis Cardinals vs. Cleveland Guardians prediction
I’m on the Cardinals here. I get the case to be made for Cleveland as a home underdog, I’m just not a fan of Slade Cecconi and I just think the Cardinals have the more trustworthy lineup in this matchup. Cleveland hasn’t been able to drum up consistent offense as of late, and I think that the Cardinals pick up another win in this one to keep their foot on the gas. Give me St. Louis here.