Cleveland Guardians vs Seattle Mariners Prediction 3/26/2026 Today’s MLB Picks

In this article, we will formulate a Guardians vs Mariners Prediction for this MLB matchup on Thursday, March 26th. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Preview

The Seattle Mariners finished last season with a 90-72 record and were placed 1st in the AL West. They had a 51-30 home record and 39-42 away record and were 96-72-6 in over/under.

Last season the Mariners had a .244 batting average, .320 OBP and .420 Slugging percentage. Seattle’s pitching staff had a 3.87 ERA and 1.22 WHIP. Julio Rodríguez led the Mariners with 174 hits. Dominic Canzone was the team’s best hitter with a .300 batting average. Cal Raleigh led the team in RBI, with 125 and added a team-high 47 home runs.

Logan Gilbert (R) is the projected starting pitcher for the Mariners, and last season he had a 6-6 record, 3.44 ERA and 1.03 WHIP.

Cleveland Guardians Preview

The Cleveland Guardians finished last season with an 88-74 record and were placed 1st in the AL Central. They had a 45-36 home record and 43-38 away record and were 72-86-7 in over/under.

Last season the Guardians had a .226 batting average, .296 OBP and .373 Slugging percentage. Cleveland’s pitching staff had a 3.70 ERA and 1.26 WHIP. Steven Kwan led the Guardians with 170 hits. José Ramírez was the team’s best hitter with a .283 batting average. José Ramírez also led the team in RBI, with 85 and added a team-high 30 home runs.

Tanner Bibee (R) is the projected starting pitcher for the Guardians, and last season he had a 12-11 record, 4.24 ERA and 1.23 WHIP. Cleveland plays the Dodgers, Cubs, and Royals next. 

Cleveland Guardians @ Seattle Mariners Betting Trends: March 26, 2026

• Probable Starting Pitcher: Logan Gilbert      Record this season: –      ERA: –
• Home Record: –
• Last 5 against Guardians: 1-2

Why the Seattle Mariners will win

• The Mariners have won eight of their last nine home openers.
• The Guardians have lost each of their last three games at T-Mobile Park.
• The Mariners have covered the run line in eight of their last nine home openers.
• The Guardians have failed to cover the run line in each of their last seven Thursday games as underdogs against AL West opponents.
• The Mariners have led after 3 innings in four of their last five games as favorites against AL Central opponents.
• The Mariners have led after 5 innings in six of their last seven home games against AL Central opponents.

• Probable Starting Pitcher: Tanner Bibee       Record this season: –      ERA: –
• Road Record: –
• Last 5 against Mariners: 1-1

Why the Cleveland Guardians will win

• The Guardians have won each of their last seven games as road underdogs.
• The Mariners have lost each of their last five games as home favorites.
• The Guardians have covered the run line in each of their last 11 games as underdogs.
• The Mariners have failed to cover the run line in each of their last five games as home favorites.
• The Guardians have won the first inning in three of their last four road games.
• The Guardians have led after 5 innings in each of their last six road night games.
• The Guardians have led after 3 innings in three of their last four road games.

Total Runs Facts

• Each of the Mariners’ last four games as favorites have gone OVER the total runs line.
• Five of the Guardians’ last six road games have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Mariners’ last 12 Thursday night games at T-Mobile Park.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Guardians’ last six Thursday night games against AL West opponents.

Seattle Mariners Player Prop Facts

• Julio Rodriguez has hit a home run in three of the Mariners’ last five night games.
• Logan Gilbert has recorded seven or more strikeouts in 13 of his last 14 appearances with the Mariners as home favorites against AL opponents.
• Brendan Donovan has recorded at least one hit in each of his last 10 appearances in night games.
• Brendan Donovan has recorded at least one Double in four of his last five appearances.
• Logan Gilbert has recorded a win in four of his last five appearances with the Mariners as favorites against AL opponents.

Cleveland Guardians Player Prop Facts

• Rhys Hoskins has hit a home run in each of his three previous road appearances against the Mariners.
• Rhys Hoskins has recorded at least one hit in each of his last six appearances with his team as an underdog against AL opponents.
• Rhys Hoskins has recorded a Double in three of his last four appearances with his team as a road underdog against AL opponents.

Guardians vs Mariners Prediction

The Mariners were 4-2 in their six meetings against the Guardians last season, sweeping their only series in Seattle by 3-0 wins. Over is 7-3 in their last 10 meetings.  

In this Guardians vs Mariners Prediction, the Mariners are coming as -170 home favorites. Both teams were very good last season and Seattle made it all the way to the ALCS Finals where they lost to Toronto. Cleveland had the third-best bullpen in the league last season but they were also the second-worst hitting team against right-handed pitching. Bibee has also been significantly weaker on the road for the Guardians with a 5.17 road ERA, while Gilbert has been excellent last season and elite at home with a 2.24 home ERA. Take the Mariners to win their season opener in front of their home crowd.

Nikos Lagouretos's Pick: Seattle Mariners ML