Cleveland Guardians vs Minnesota Twins Prediction 5/21/25 MLB Picks

The Cleveland Guardians and Minnesota Twins meet Wednesday in MLB action at Target Field. Here’s a Cleveland Guardians vs Minnesota Twins Prediction. This article will include a Cleveland Guardians vs Minnesota Twins Pick.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 25-21 on the year and play the Tigers, Dodgers, and Angels next. The Cleveland Guardians are batting .233 on the season, have a .307 OBP, and a .380 slugging percentage. The Cleveland Guardians’ pitching staff has a 4.14 ERA and a 1.41 WHIP. Steven Kwan leads the Cleveland Guardians with 56 hits and 17 RBI, while Jose Ramirez and Gabriel Arias have combined for 85 hits and 42 RBI. 

Gavin Williams gets the ball for the Cleveland Guardians, and he is 3-2 with a 4.29 ERA and 51 strikeouts this season. Williams is 2-2 with a 3.79 ERA and 16 strikeouts in his career against the Minnesota Twins.

Minnesota Twins Betting Preview

The Minnesota Twins are 26-21 on the year and play the Royals, Rays, and Mariners next. The Minnesota Twins are batting .242 on the season, have a .310 OBP, and a .386 slugging percentage. The Minnesota Twins pitching staff has a 3.20 ERA and a 1.14 WHIP. Ty France leads the Minnesota Twins with 42 hits and 23 RBI, while Trevor Larnach and Byron Buxton have combined for 83 hits and 50 RBI.

Chris Paddack gets the ball for the Minnesota Twins, and he is 2-3 with a 4.05 ERA and 33 strikeouts this season. Paddack is 0-0 with a 2.08 ERA and 8 strikeouts in his career against the Cleveland Guardians.

Why the Minnesota Twins will win

• The Twins have won each of their last nine home games.
• The Guardians have lost 10 of their last 11 day games on the first leg of a doubleheader.
• The Twins have covered the run line in each of their last six home games against American League opponents.
• The Guardians have failed to cover the run line in seven of their last eight road games against American League opponents that held a winning record.
• The Twins have led after 3 innings in five of their last six games as home favorites against American League opponents.
• The Twins have led after 5 innings in five of their last six games as home favorites against American League opponents.

Why the Cleveland Guardians will win

• The Guardians have won 10 of their last 11 games as underdogs against the Twins.
• The Twins have lost each of their last three games as favorites against AL Central opponents.
• The Guardians have covered the run line in each of their last six games as underdogs against the Twins.
• The Twins have failed to cover the run line in nine of their last 10 games against the Guardians at Target Field following a loss.
• The Guardians have led after 3 innings in four of their last five games as underdogs against AL Central opponents.

Minnesota Twins Player Prop Facts

• Trevor Larnach has hit a home run in two of the Twins’ last three home games against AL Central opponents.
• Ty France has recorded at least one RBI in five of his last six appearances at Target Field against AL opponents that held a winning record.
• Ty France has recorded at least one Single in seven of the Twins’ last eight games against AL Central opponents.
• Bailey Ober has recorded five or more strikeouts in eight of his last nine home appearances against AL opponents.
• Byron Buxton has scored at least one run in each of the Twins’ last seven games against AL opponents.
• Bailey Ober has recorded a win in each of his last four appearances with the Twins as home favorites against AL Central opponents.
• Harrison Bader has recorded at least one hit in each of his last 11 appearances against opponents that held a winning record.

Cleveland Guardians Player Prop Facts

• Carlos Santana has recorded at least one RBI in four of the Guardians’ last five road games.
• Steven Kwan has scored at least one run in each of the Guardians’ last four road games against AL Central opponents.
• Jose Ramirez has recorded at least one Single in 14 of his last 15 appearances with the Guardians as underdogs.
• Steven Kwan has recorded at least one hit in each of the Guardians’ last 11 games against AL opponents that held a winning record.
• Austin Hedges has hit a home run in each of his last two appearances with the Guardians as road underdogs against the Twins.
• Jose Ramirez ranks T10th in the league in Steals (12) this season.

Cleveland Guardians vs Minnesota Twins Prediction

The Guardians just can’t get out of their own way as they’ve lost six of their last eight games. Even with Williams improving lately, he still has a 4.29 ERA and 1.64 WHIP on the season. In 18.2 road innings, Williams has a 5.30 ERA and a .270 allowed batting average. The Twins have lost once since May 3 and have a pitching staff that’s absolutely dealing. Paddack has been hit or miss at times this season, but he’s allowed 11 hits and four runs in his last 19.1 innings. At home in 21.1 innings, Paddack has a 2.95 ERA and .218 allowed batting average. I’m not stepping in front of the Twins. Give me the home team and the soft price.