Cleveland Guardians vs Minnesota Twins Prediction 9/13/2026 Today’s MLB Picks

The Cleveland Guardians and the Minnesota Twins will meet Sunday afternoon in the closing game of an American League series at Target Field in Minneapolis, Minnesota. Let’s take a look at this matchup from a betting perspective.

Cleveland Guardians Betting Preview

The Cleveland Guardians enter Sunday’s matchup with a 75-74 overall record (2nd in the American League Central) and a robust 39-35 mark on the road. The Guardians offense has been inconsistent this season. Cleveland has compiled 606 runs scored (27th in MLB), 227 doubles, a .236 team batting average and 139 home runs which ranks 30th in Major League Baseball.

The Guardians arrive at tomorrow’s game in below average form. Cleveland has lost three of the team’s last five games played this season, including a 9-5 loss to the Baltimore Orioles earlier this week.

The Cleveland Guardians will turn to right hander Tanner Bibee in this game. In 30 starts made in 2026, Bibee has compiled a 5-15 win-loss record, a 4.22 ERA, a 1.20 WHIP (25th in MLB) and 133 strikeouts in 170.2 innings pitched. Tanner Bibee arrives at this contest in subpar form, allowing five earned runs or more in two of his last five starts made this season. Bibee will look to rebound from his recent struggles on the mound in tomorrow afternoon’s matchup with the Minnesota Twins.

The Guardians lineup features shortstop Brayan Rocchio and outfielder Chase DeLauter. Ramirez has tallied 11 home runs, 48 RBIs and a .697 OPS. Brayan Rocchio has tallied a .246 batting average, 13 home runs, 65 RBIs, 21 doubles, 34 walks and a .680 OPS. DeLauter has amassed .291 batting average (10th in MLB), 14 home runs, 62 RBIs and an .820 OPS.                                                               

Minnesota Twins Betting Preview

The Minnesota Twins enter Sunday afternoon’s matchup with a 70-78 overall record (3rd in the American League Central) and a 39-35 mark at home. Minnesota has played below average baseball recently, losing four of the team’s last six games, including a 7-2 loss to the Detroit Tigers three days ago.

The Twins will start talented right hander Joe Ryan in this contest. In 24 starts made in 2026, Ryan has compiled a 6-9 win-loss record, a 3.68 ERA, a 1.13 WHIP and 145 strikeouts in 129.2 innings pitched.

The Minnesota Twins lineup features second baseman Kody Clemens and designated hitter Josh Bell. Kody Clemens has tallied 26 home runs (24th in MLB), 75 RBIs and a .776 OPS. Josh Bell has compiled a .253 batting average, 19 home runs, 86 RBIs (15th in MLB) and a .739 OPS.  

Why the Cleveland Guardians will win.

• Starting pitching. In 30 starts made in 2026, Tanner Bibee has compiled a 4.22 ERA, a 1.20 WHIP (25th in MLB) and 133 strikeouts in 170.2 innings pitched.
• Ability to win on the road. The Cleveland Guardians have amassed a 39-34 record away from home this season.

Why the Minnesota Twins will win.

 • Starting pitching. In 24 starts made in 2026, Joe Ryan has compiled a 6-9 win-loss record, a 3.68 ERA, a 1.13 WHIP and 145 strikeouts in 129.2 innings pitched.
• Home field advantage. The Twins have played quality baseball at home this season, compiling a 39-34 record at Target Field.
• Enhanced motivation. The Minnesota Twins have lost four of the team’s last six games.

Cleveland Guardians vs. Minnesota Twins Prediction

In my view, this matchup favors the Minnesota Twins. Why? Cleveland starting pitcher Tanner Bibee arrives at this contest in subpar form, allowing five earned runs or more in two of his last five starts made this season which is a concern when facing a formidable Minnesota lineup. Additionally, the Twins have played competitive baseball on the road, amassing a 39-34 win-loss record away from home. With that said, I am backing the Minnesota Twins on the moneyline in this game.

Hans Geevers's Pick: Minnesota Twins ML