Jun 29, 2025; Houston, Texas, USA; Houston Astros second baseman Jose Altuve (27) crosses home plate after hitting a two-run home run to left field against the Chicago Cubs during the fifth inning at Daikin Park. Mandatory Credit: Erik Williams-Imagn Images

Cleveland Guardians vs Chicago Cubs Prediction 07/01/2025 Picks

Pick details

Cleveland (40-42) vs Chicago (49-35)

July 1, 2025 at 08:05 PM EDT

The Line: Betting Odds: Chicago -1.5 — Over/Under: +8

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The Cleveland Guardians and Chicago Cubs meet Tuesday in MLB action at Wrigley Field. Here’s a Cleveland Guardians vs Chicago Cubs Prediction. This article will include a Cleveland Guardians vs Chicago Cubs Pick.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 40-42 on the year and play the Tigers, Astros, and White Sox next. The Cleveland Guardians are batting .226 on the season, have a .298 OBP, and a .366 slugging percentage. The Cleveland Guardians pitching staff has a 4.03 ERA and a 1.37 WHIP. Jose Ramirez leads the Cleveland Guardians with 92 hits and 38 RBI, while Steven Kwan and Carlos Santana have combined for 153 hits and 62 RBI. 

Gavin Williams gets the ball for the Cleveland Guardians, and he is 5-3 with a 3.68 ERA and 80 strikeouts this season. This will be Williams’ first career game against the Chicago Cubs.

Chicago Cubs Betting Preview

The Chicago Cubs are 49-35 on the year and play the Cardinals, Twins, and Yankees next. The Chicago Cubs are batting .256 on the season, have a .325 OBP, and a .446 slugging percentage. The Chicago Cubs pitching staff has a 3.87 ERA and a 1.25 WHIP. Kyle Tucker leads the Chicago Cubs with 91 hits and 52 RBI while Nico Hoerner and Pete Crow-Armstrong have combined for 175 hits and 97 RBI.

Matthew Boyd gets the ball for the Chicago Cubs, and he is 7-3 with a 2.65 ERA and 82 strikeouts this season. Boyd is 4-7 with a 4.06 ERA and 75 strikeouts in his career against the Cleveland Guardians.

Why the Chicago Cubs will win

The Cubs have won each of their last six home games following a road loss.
The Guardians have lost each of their last five night games against NL Central opponents.
The Guardians have failed to cover the run line in each of their last six games.
The Cubs have covered the run line in seven of their last eight night games against American League opponents following a loss.
The Guardians have trailed after 5 innings in four of their last five night games against NL Central opponents that held a winning record.
The Guardians have trailed after 3 innings in each of their last four games against opponents that held a winning record.

Why the Cleveland Guardians will win

The Guardians have won each of their last three games as underdogs against the Cubs.
The Cubs have lost five of their last six night games against AL Central opponents.
The road team has covered the run line in 11 of the Guardians’ last 12 games.
The Cubs have failed to cover the run line in seven of their last eight games at Wrigley Field against teams that held a losing record.
The Cubs have trailed after 5 innings in three of their last four night games against AL Central opponents.
The Cubs have trailed after 3 innings in three of their last four games against American League opponents.

Chicago Cubs Player Prop Facts

Kyle Tucker has hit a home run in each of his last three appearances in night games against AL teams that held a losing record.
Matthew Boyd has recorded six or more strikeouts in six of his last seven appearances in night games against teams that held a losing record.
Nico Hoerner has recorded two or more hits in each of the Cubs’ last seven home games against AL opponents that held a losing record.
Matthew Boyd has recorded a win in six of his last seven appearances at Wrigley Field.
Kyle Tucker ranks 4th amongst qualified players for On Base Percentage (.395) this season.

Cleveland Guardians Player Prop Facts

Lane Thomas has hit a home run in two of the Guardians’ last three night games against opponents that held a winning record.
Carlos Santana has recorded at least one hit in 12 of his last 13 road appearances after not playing the previous day.
Jose Ramirez ranks 9th amongst qualified players for Batting Average (.309) this season.

Cleveland Guardians vs Chicago Cubs Prediction

Williams has been good for the Guardians this season, but it doesn’t mean much if the offense can’t score. The Guardians have been shutout in three of their last four games. In three of Williams’ last four starts, they’ve scored three or fewer runs. Boyd looks like an all-star with his 2.65 ERA and 1.10 WHIP. In his last 30.1 innings, Boyd allowed 18 hits and six earned runs. In 41 home innings, Boyd has a 2.41 ERA and .212 allowed batting average. I doubt this is a spot where Guardians find their spark offensively. Give me the Cubs on Tuesday night.

Randy Chambers's Pick: Chicago Cubs

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