Cincinnati Reds vs San Diego Padres Prediction 06/29/2025 Picks

The San Diego Padres and the Cincinnati Reds meet Sunday in MLB action from Great American Ballpark. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Diego Padres vs. Cincinnati Reds prediction.

Starting Pitching Matchup

The San Diego Padres will send out Stephen Kolek here and Kolek is 3-3 with a 3.95 ERA and 42 strikeouts this season. This will be Kolek’s first career start against the Reds. The Cincinnati Reds will send Nick Lodolo out for the start here and Lodolo is 5-5 with a 3.63 ERA and 80 strikeouts this season. In his career, Lodolo is 1-1 with a 3.00 ERA and 19 strikeouts against the Padres.

San Diego Padres Recap

The San Diego Padres come into this game looking to add on to their 6-4 win over the Reds on Saturday to improve to 45-37 on the year. After this series, the Padres will head on the road for a series against the Philadelphia Phillies.

Padres Win 5 Of Their Last 7

Manny Machado has 91 hits including a team-high 20 doubles, 13 home runs, 47 RBIs and 8 stolen bases while Fernando Tatis Jr. has 78 hits with a team-high 15 home runs and 37 RBIs along with 15 stolen bases of his own this season. Luis Arraez has added 87 hits with 16 doubles, 4 triples, 3 home runs and 30 RBIs while Jackson Merrill’s added 56 hits with 5 home runs and 26 RBIs as well. Xander Bogaerts also has 15 doubles and 13 stolen bases as well this season. Gavin Sheets also has 12 doubles, 12 home runs and 46 RBIs as well this season.

Why the San Diego Padres will win

The Padres have won each of their last seven day games against NL Central opponents.
The Reds have lost four of their last five games as home favorites against National League opponents.
The Padres have covered the run line in each of their last eight games as underdogs against NL Central opponents.
The Reds have failed to cover the run line in nine of their last 10 day games against the Padres following a loss.

San Diego Padres Player Prop Facts

Gavin Sheets has hit a home run in each of his last two appearances with his team as a road underdog against the Reds.
Jose Iglesias has recorded at least one hit in each of his last 13 appearances in day games against NL Central teams that held a winning record.
Manny Machado ranks T8th in the league in Hits (93) this season.

Cincinnati Reds Recap

The Cincinnati Reds come into this game looking to rebound from their loss at the hands of the Padres on Saturday to drop to 43-40 this season. After this series, the Reds will trek on the road for a series with the Boston Red Sox.

Reds Looking To String Wins Together

Elly De La Cruz has 86 hits with 18 home runs, 55 RBIs, 15 doubles and 21 stolen bases while TJ Friedl has 85 hits with 13 doubles, 8 home runs and 30 RBIs with 9 stolen bases. Gavin Lux has added 62 hits with 14 doubles and 35 RBIs while Spencer Steer has 6 home runs and 27 RBIs and Matt McLain has added 9 homers, 27 RBIs and 11 stolen bases as well on the year. Jose Trevino’s also chipped in 17 doubles as well this season.

Why the Cincinnati Reds will win

The Reds have won eight of their last nine games against NL West opponents following a loss.
The Padres have lost seven of their last eight games against National League opponents following a win.
The Padres have failed to cover the run line in each of their last seven games following a win.
The Reds have covered the run line in seven of their last eight day games following a loss.

Cincinnati Reds Player Prop Facts

Tyler Stephenson has hit at least one home run in four of his last six appearances with the Reds as favorites against NL West opponents.
Jose Trevino has recorded at least one Double in each of his last three appearances against NL opponents that held a winning record.
Nick Lodolo has recorded a win in three of his last four appearances against NL West opponents.
Nick Lodolo has recorded five or more strikeouts in each of his last four appearances against opponents that held a winning record.
Spencer Steer has recorded at least one hit in each of his last eight home appearances against NL West opponents that held a winning record.
Elly De La Cruz ranks T4th in the league in Steals (22) this season.

Total Runs Facts

Six of the Padres’ last seven games as underdogs against NL Central opponents have gone UNDER the total runs line.
Four of the Reds’ last five games after playing the previous day have gone UNDER the total runs line.

San Diego Padres vs. Cincinnati Reds Prediction

I’m on the over here. I just don’t love the matchup for Stephen Kolek, who has been getting hit pretty hard in some of his recent outings, and I also am not a fan of this matchup for Nick Lodolo given the struggles he has had at Great American Ballpark, not just this season but for the better part of his career. I think runs will be scored early and often in this game, so I’m rolling with the over in this one.