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Cincinnati Reds vs San Diego Padres Prediction 06/28/2025 Picks
Pick details
San Diego (44-37) vs Cincinnati (43-39)
June 28, 2025 at 04:10 PM EDT
The Line: Betting Odds: Cincinnati -150 — Over/Under: +9.5
The San Diego Padres and the Cincinnati Reds meet Saturday in MLB action from Great American Ballpark. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Diego Padres vs. Cincinnati Reds prediction.
Starting Pitching Matchup
The San Diego Padres will send out Randy Vasquez for the start here and Vasquez is 3-4 with a 3.60 ERA and 45 strikeouts this season. This will be Vasquez’s first career start against the Reds. The Cincinnati Reds will start Andrew Abbott for the start here and Abbott is 7-1 with a 1.79 ERA and 72 strikeouts this season. In his career, Abbott is 1-0 with a 0.61 ERA and 14 strikeouts against the Padres.
San Diego Padres Recap
The San Diego Padres come into this game looking to bounce back from their 8-1 loss at the hands of the Cincinnati Reds on Friday in the series opener to sit at 44-37 on the year. After this series, the Padres will head on the road for a series against the Philadelphia Phillies.
Padres Split Last Ten Games
Manny Machado has 91 hits including a team-high 20 doubles, 13 home runs, 47 RBIs and 8 stolen bases while Fernando Tatis Jr. has 78 hits with a team-high 15 home runs and 37 RBIs along with 15 stolen bases of his own this season. Luis Arraez has added 87 hits with 16 doubles, 4 triples, 3 home runs and 30 RBIs while Jackson Merrill’s added 56 hits with 5 home runs and 26 RBIs as well. Xander Bogaerts also has 15 doubles and 13 stolen bases as well this season. Gavin Sheets also has 12 doubles, 12 home runs and 46 RBIs as well this season.
Why the San Diego Padres will win
The Padres have won each of their last four games as underdogs against NL Central opponents following a loss.
The Reds have lost seven of their last eight games against the Padres following a win.
The Padres have covered the run line in each of their last eight day games against National League opponents following a loss.
The Reds have failed to cover the run line in seven of their last eight games as favorites following a win.
San Diego Padres Player Prop Facts
Xander Bogaerts has recorded a Double in four of the Padres’ last five games as underdogs against NL opponents.
Jose Iglesias has recorded at least one hit in each of his last 12 appearances in day games against NL Central teams that held a winning record.
Manny Machado has hit a home run in three of the Padres’ last four games as underdogs against NL Central opponents.
Cincinnati Reds Recap
The Cincinnati Reds come into this game looking to add on to their win over the Padres from Friday to improve to 43-39 on the year. After this series, the Reds will travel to Fenway Park to sit at 43-39 this season.
Reds Win 4 Of Their Last 5 Games
Elly De La Cruz has 86 hits with 18 home runs, 55 RBIs, 15 doubles and 21 stolen bases while TJ Friedl has 85 hits with 13 doubles, 8 home runs and 30 RBIs with 9 stolen bases. Gavin Lux has added 62 hits with 14 doubles and 35 RBIs while Spencer Steer has 6 home runs and 27 RBIs and Matt McLain has added 9 homers, 27 RBIs and 11 stolen bases as well on the year. Jose Trevino’s also chipped in 17 doubles as well this season.
Why the Cincinnati Reds will win
The Reds have won each of their last 10 home games against NL West opponents that held a winning record.
The Padres have lost four of their last five road games.
The Reds have covered the run line in each of their last six games against NL West opponents.
The Padres have failed to cover the run line in each of their last five games.
Cincinnati Reds Player Prop Facts
Tyler Stephenson has hit at least one home run in four of his last five appearances with the Reds as favorites against NL West opponents.
Jose Trevino has recorded at least one Double in each of his last three appearances against NL opponents that held a winning record.
Austin Hays has recorded at least one hit in each of his last nine home appearances.
Total Runs Facts
Each of the Padres’ last six games as underdogs against NL Central opponents have gone UNDER the total runs line.
Each of the Reds’ last four games after playing the previous day have gone UNDER the total runs line.
San Diego Padres vs. Cincinnati Reds Prediction
I’m backing the Reds in this one. I get the case to be made for the Padres who still have a decent staff from top to bottom. However, the Reds have a massive edge in starting pitching and Abbott is arguably Cincinnati’s ace who is of a rare breed that pitches well at hitter-friendly Great American. I think the Reds do enough to get the win here so give me Cincinnati.