Cincinnati Reds vs Pittsburgh Pirates Prediction 5/21/25 MLB Picks

The Cincinnati Reds and Pittsburgh Pirates meet Wednesday in MLB action at PNC Park. Here’s a Cincinnati Reds vs Pittsburgh Pirates Prediction. This article will include a Cincinnati Reds vs Pittsburgh Pirates Pick.

Cincinnati Reds Betting Preview

The Cincinnati Reds are 25-25 on the year and play the Cubs, Royals, and Cubs next. The Cincinnati Reds are batting .243 on the season, have a .319 OBP, and a .395 slugging percentage. The Cincinnati Reds pitching staff has a 3.49 ERA and a 1.16 WHIP. TJ Friedl leads the Cincinnati Reds with 49 hits and 18 RBI, while Elly De La Cruz and Gavin Lux have combined for 93 hits and 53 RBI. 

Brady Singer gets the ball for the Cincinnati Reds, and he is 5-2 with a 5.01 ERA and 43 strikeouts this season. Singer is 2-1 with a 6.32 ERA and 15 strikeouts in his career against the Pittsburgh Pirates.

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 16-33 on the year and play the Brewers, Diamondbacks, and Padres next. The Pittsburgh Pirates are batting .216 on the season, have a .297 OBP, and a .318 slugging percentage. The Pittsburgh Pirates’ pitching staff has a 4.03 ERA and a 1.26 WHIP. Ke’Bryan Hayes leads the Pittsburgh Pirates with 42 hits and 15 RBI, while Bryan Reynolds and Isiah Kiner-Falefa have combined for 74 hits and 31 RBI.

Andrew Heaney gets the ball for the Pittsburgh Pirates, and he is 2-3 with a 3.02 ERA and 38 strikeouts this season. Heaney is 2-1 with a 2.60 ERA and 21 strikeouts in his career against the Cincinnati Reds.

Why the Pittsburgh Pirates will win

• The Reds have lost each of their last six Wednesday day games as favorites against NL Central opponents.
• The Pirates have won each of their last four Wednesday games as home underdogs against NL Central opponents.
• The Pirates have covered the run line in each of their last seven Wednesday games as home underdogs against National League opponents.
• The Reds have failed to cover the run line in 12 of their last 13 Wednesday games as favorites against NL Central opponents.

Why the Cincinnati Reds will win

• The Pirates have lost each of their last six games following a win.
• The Reds have won five of their last six games after playing the previous day.
• The Pirates have failed to cover the run line in eight of their last nine games against NL Central opponents following a win.
• The Reds have covered the run line in seven of their last eight road games against National League opponents following a road loss.

Pittsburgh Pirates Player Prop Facts

• Adam Frazier has hit a home run in two of his last three home appearances against the Reds after playing the previous day.
• Joey Bart has recorded at least one RBI in three of the Pirates’ last four games against NL opponents at PNC Park.
• Bryan Reynolds has scored a run in three of the Pirates’ last four home games against NL Central opponents.
• Bryan Reynolds has recorded a Single in each of the Pirates’ last four games.
• Bryan Reynolds has recorded at least one hit in 10 of his last 11 home appearances against the Reds after playing the previous day.

Cincinnati Reds Player Prop Facts

• Elly De La Cruz has recorded at least one RBI in four of the Reds’ last five games as road favorites against NL Central opponents.
• TJ Friedl has recorded at least one Single in seven of the Reds’ last eight road games against NL Central opponents.
• Brady Singer has recorded five or more strikeouts in six of his last seven appearances in day games against NL teams that held a losing record.
• Spencer Steer has recorded at least one hit in each of the Reds’ last nine games as favorites.
• Jose Trevino has scored at least one run in each of his last four road appearances after playing the previous day.
• Will Benson has hit at least one home run in each of the Reds’ last two day games.
• Brady Singer has recorded a win in each of his last three appearances with his team as a road favorite.
• Brady Singer ranks T7th in the league for Wins (5) this season.

Cincinnati Reds vs Pittsburgh Pirates Prediction

The Reds are having their best week of the season with wins in five of their last six games, and they had their chances to win last night but couldn’t score a run. Singer has been a disaster this season, which includes allowing 19 hits and 14 runs in his last 13.1 innings. However, the Pirates have been fading material all season, and even with a win yesterday, they haven’t won two straight games since April 22-23. Heaney has been solid with his 3.02 ERA and 1.14 WHIP, but the Pirates have also lost four straight games he’s pitched due to a lack of offense. The Pirates have been shut out in two of Heaney’s last four starts. Even with Singer throwing up on himself, give me the Reds and the cheap price.