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Cincinnati Reds vs Milwaukee Brewers Prediction 4/4/25 MLB Picks

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Milwaukee Brewers (3-4) vs Cincinnati Reds (2-5)

April 4, 2025 at 08:10 PM EDT

The Line: Betting Odds: Milwaukee Brewers -120 / Cincinnati Reds +100 — Over/Under: 8

(Get latest betting odds)

The Cincinnati Reds and Milwaukee Brewers meet Friday in MLB action at American Family Field. Here’s a Cincinnati Reds vs Milwaukee Brewers Prediction. This article will include a Cincinnati Reds vs Milwaukee Brewers Pick.

Cincinnati Reds Betting Preview

The Cincinnati Reds are 2-5 on the year and play the Giants, Pirates, and Mariners next. The Cincinnati Reds are batting .197 on the season, have a .254 OBP, and a .318 slugging percentage. The Cincinnati Reds pitching staff has a 2.47 ERA and a 0.85 WHIP. Elly De La Cruz leads the Cincinnati Reds with 8 hits and 8 RBI, while Matt McLain and Jeimer Candelario have combined for 11 hits and 8 RBI. 

Nick Martinez gets the ball for the Cincinnati Reds, and he is 0-1 with a 6.00 ERA and 5 strikeouts this season. Martinez is 0-0 with a 3.73 ERA and 26 strikeouts in his career against the Milwaukee Brewers.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 3-4 on the year and play the Rockies, Diamondbacks, and Tigers next. The Milwaukee Brewers are batting .218 on the season, have a .291 OBP, and a .331 slugging percentage. The Milwaukee Brewers pitching staff has a 6.68 ERA and a 1.40 WHIP. Brice Turang leads the Milwaukee Brewers with 9 hits and 4 RBI while Jackson Chourio and Sal Frelick have combined for 17 hits and 6 RBI.

The Milwaukee Brewers didn’t announce a starting pitcher at the time this article was published.

Why the Milwaukee Brewers will win

  • The Reds have lost each of their last five night games against the Brewers following a loss.
  • The home team has won six of the Brewers’ last seven games.
  • The Reds have failed to cover the run line in three of their last four games as underdogs against National League opponents.
  • The Brewers have led after 5 innings in four of their last five night games against NL Central opponents that held a losing record.

Why the Cincinnati Reds will win

  • The Brewers have lost three of their last four Friday games as home favorites.
  • The Brewers have failed to cover the run line in each of their last 10 games against the Reds following a home win.
  • The Reds have covered the run line in each of their last nine games against the Brewers following a road loss.

Cincinnati Reds vs Milwaukee Brewers Prediction

It’s hard to make a case for the Reds as they’ve been shutout in each of their last three games. The Reds have gone 28 straight innings without scoring a run. With that said, the Reds pitching staff has held up this season and it’s only a matter of time before things breakthrough offensively. The Brewers have allowed a combined two runs in their last three games and yet their pitching numbers are horrific on the season. The Reds are too talented to stay in this funk for long and it feels like we’re getting value with them in the even money role. I’ll take a shot with the Reds and the more favorable price.

Randy Chambers's Pick: Cincinnati Reds +100

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