Cincinnati Reds vs Chicago Cubs Prediction 5/6/2026 Today’s MLB Picks

In this article, we will formulate a Reds vs Cubs Prediction for this MLB matchup on Wednesday, May 6th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Preview

The Chicago Cubs have a 24-12 record this season and are sitting in the first place of the NL Central. They have a 16-5 home record and are coming off a 3-2 win at home against the Reds. They will face the Rangers and the Braves next.

The Cubs have a .258 batting average this season, .352 OBP and .428 Slugging percentage. Chicago’s pitching staff has a 3.83 ERA and 1.17 WHIP. Nico Hoerner is the team’s best hitter with a .300 batting average, also leading the team in RBI with 27. Ian Happ adds a team‑high 8 home runs.

Colin Rea (R) is the projected starting pitcher for the Cubs, and he has a 4-1 record, 4.41 ERA and 1.32 WHIP.

Cincinnati Reds Preview

The Cincinnati Reds have a 20-16 record this season and are sitting in the third place of the NL Central. They have a 10-8 away record and are coming off a 2-3 loss on the road against the Cubs. They will face the Astros and the Nationals next.

The Reds have a .218 batting average this season, .303 OBP and .384 Slugging percentage. Cincinnati’s pitching staff has a 4.45 ERA and 1.50 WHIP. Elly De La Cruz is the team’s best hitter with a .275 batting average, also adding a team‑high 10 home runs. Sal Stewart leads the team in RBI with 29.

Brady Singer (R) is the projected starting pitcher for the Reds, and he has a 2-2 record, 5.57 ERA and 1.73 WHIP.

Cincinnati Reds @ the Chicago Cubs Betting Trends: May 6, 2026

• Probable Starting Pitcher: Colin Rea      Record this season: 4-1      ERA: 4.41
• Home Record: 2-0
• Last 5 against Reds: 1-3

Why the Chicago Cubs will win

• The Cubs have won each of their last 13 home games.
• The Reds have lost each of their last seven games against NL Central opponents.
• The Reds have failed to cover the run line each of their last six Wednesday games against NL Central opponents that held a winning record.
• The Cubs have covered the run line in four of their last five night games after going to extra innings.
• The Cubs have led after 5 innings in each of their last six Wednesday games as home favorites.
• The Cubs have led after 3 innings in each of their last six Wednesday games as home favorites.

• Probable Starting Pitcher: Brady Singer      Record this season: 2-2      ERA: 5.57
• Road Record: 0-2
• Last 5 against Cubs: 1-2

Why the Cincinnati Reds will win

• The Reds have won three of their last four games as underdogs after going to extra innings.
• The Reds have covered the run line each of their last seven night games against teams that held a winning record.
• The Cubs have failed to cover the run line in each of their last six games against NL Central opponents.
• The Reds have led after 3 innings in each of their last four games against the Cubs.
• The Reds have led after 5 innings in three of their last four games against the Cubs.

Total Runs Facts

• Ten of the last 11 games between the Reds and Cubs at Wrigley Field have gone UNDER the total runs line.
• Nine of the Reds’ last 10 games following an extra innings loss have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of Colin Rea’s 10 previous appearances as a starter against the Reds.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 12 of the Reds’ last 14 games at Wrigley Field.

Chicago Cubs Player Prop Facts

• Seiya Suzuki has hit a home run in four of the Cubs’ last seven night games.
• Alex Bregman has recorded at least one hit in each of his last six appearances against NL Central opponents.
• Colin Rea ranks T9th in the league for Wins (4) this season.

Cincinnati Reds Player Prop Facts

• JJ Bleday has hit a home run in three of the Reds’ last four games.
• Brady Singer has recorded four or more strikeouts in 11 of his 12 previous appearances in night games against NL teams that held a winning record.
• Spencer Steer has recorded at least one hit in each of the Reds’ last 10 road games.
• Brady Singer has recorded a win in three of his last four appearances in night games against teams that held a winning record.
• Elly De La Cruz ranks T10th in the league in Home Runs (10) this season.

Matchup/League Facts

• The Cubs rank 1st in the league for on-base percentage this season (.352).
• The Cubs rank 1st in the league for walks this season (168).
• The Reds rank 30th in the league for hits this season (260).
• The Reds rank 30th in the league for batting average this season (.218).

Reds vs Cubs Prediction

The Reds are 6-3 in their last 9 meetings against the Cubs but the Cubs have won their last three meetings in Chicago.

In this Reds vs Cubs Prediction, the Cubs are coming as -180 home favorites. The Cubs have been the hottest team in baseball with seven consecutive wins, while on the flip side, the Reds have been struggling with five straight losses. I will once again take the Cubs to win, as I trust more Rea at home, where he has a 3.00 ERA, while Singer has been bad this season with a 5+ ERA, 1.70+ WHIP and terrible on the road, with a 7.41 road ERA and has to face the third-best offense in baseball. Take the Cubs on the moneyline.

Nikos Lagouretos's Pick: Chicago Cubs ML