Cincinnati Reds vs Chicago Cubs Prediction 08/06/2025 Today’s MLB Picks

In this article, we will formulate a Reds vs Cubs prediction for this MLB game on Wednesday, August 6, at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup.

Cincinnati Reds Betting Preview

The Cincinnati Reds (60-54, 27-28 Away) swept the Rays, lost to the Dodgers and Braves, but will win this series against the Cubs after defeating them in the opening two duels. After a tight 3-2 win in Game 1, the Reds secured a 5-1 victory on Tuesday. Spencer Steer led the offense with four RBI, while Zack Littell got the win in his first start for Cincy after allowing one run on three hits with eight strikeouts and two walks across 7.0 innings of work.

This season, the Reds average 4.57 runs per game (10th in the MLB) on a .247/.321/.393 triple-slash. When it comes to pitching, the Reds’ staff has a 3.89 ERA (15th) and 1.24 WHIP (11th). Elly De La Cruz leads the Reds with a .279 batting average, 19 home runs, and 73 RBI this season.

Andrew Abbott will take the mound for the Reds on Wednesday. The 26-year-old left-hander has an 8-1 record in 19 starts this year with a 2.15 ERA and 1.11 WHIP in 108.2 innings.

Chicago Cubs Betting Preview

The Chicago Cubs (65-58, 35-22 Home) lost to the Milwaukee Brewers and defeated the Baltimore Orioles in the last two series, but will lose the current one to the Reds. The Cubs are hoping to avoid a sweep following 3-2 and 5-1 losses. Last night, Matt Show hit a solo homer, which was the lone run for the offense, while Shota Imanaga pitched for 6.1 innings in a no-decision, allowing one run on three hits with seven strikeouts and no walks. Andrew Kittredge took the loss.

This year, the Cubs average 5.22 runs per game (1st in the MLB) on a .255/.324/.441 triple-slash. When it comes to pitching, the Cubs’ staff has a 3.92 ERA (16th) and 1.22 WHIP (6th). Seiya Suzuki leads the Cubs with a .247 batting average, 26 home runs, and 82 RBI this season.

The projected starting pitcher for the Cubs is Cade Horton, who is 5-3 in 13 starts this season, with a 3.42 ERA and 1.29 WHIP in 73.2 innings.

Total Runs Facts

• Each of the Reds’ last nine day games against National League opponents have gone UNDER the total runs line.
• Four of the Cubs’ last five day games against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Reds’ last nine day games at Wrigley Field.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last four games between the Reds and Cubs.

Matchup/League Facts

• The Cubs rank 3rd in the league for runs scored this season (582).
• The Cubs rank 3rd in the league for slugging percentage this season (.438).
• The Reds rank 10th in the league for runs scored this season (520).
• The Reds rank 21st in the league for home runs this season (117).

Reds vs Cubs Prediction

The teams have traded wins in the past few years, each recording five in the previous ten H2H encounters. This season, the series is tied at 4-4. Four of the last five H2H duels went Under, and I expect another low-scoring affair on Wednesday, considering the pitching matchup. Andrew Abbott has been excellent lately; he allowed more than two runs just once in his last ten starts and is Cincinnati’s best pitcher this season. Cade Horton, on the other hand, was fantastic in July, posting a 1.52 ERA, while in four of his previous five starts, he registered a shutout. We will watch some great pitching and defense here. Go with Under.