Jun 15, 2025; Arlington, Texas, USA;  Chicago White Sox third baseman Miguel Vargas (20) hits a home run during the sixth inning against the Texas Rangers at Globe Life Field. Mandatory Credit: Kevin Jairaj-Imagn Images

Chicago White Sox vs St. Louis Cardinals Prediction 06/17/2025 Picks

Pick details

St. Louis (37-35) vs Chicago (23-49)

June 17, 2025 at 07:40 PM EDT

The Line: Betting Odds: Chicago +130 — Over/Under: 8.5

(Get latest betting odds)

The St. Louis Cardinals and the Chicago White Sox meet Tuesday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a St. Louis Cardinals vs. Chicago White Sox prediction.

Starting Pitching Matchup

The St. Louis Cardinals will send out Matthew Liberatore here and Liberatore is 3-6 with a 4.17 ERA and 62 strikeouts this season. This will be Liberatore’s second career start against the White Sox. Shane Smith will start this one for the White Sox and is 3-3 with a 2.37 ERA and 64 strikeouts this season. This will be Smith’s first career start against St. Louis.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to bounce back from their 3-2 loss at the hands of the Milwaukee Brewers last time out to sit at 37-35 on the year. After this series, the Cardinals will head home for a series against the Cincinnati Reds.

Cardinals Lose 7 Of Their Last 8

Brendan Donovan has a team-high 79 hits along with 20 doubles, 4 home runs and 26 RBIs while Lars Nootbaar has 60 hits with 8 home runs, 28 RBIs, 12 doubles and 4 stolen bases. Nolan Arenado also has 62 hits with 11 doubles, 8 home runs and 36 RBIs of his own and Victor Scott II has 50 hits with 8 doubles, a triple, 22 RBIs and a team-high 19 stolen bases. Willson Contreras has also chipped in  hits with 14 doubles, 7 home runs and 39 RBIs of his own as well this season. Masyn Winn’s added 59 points with 11 doubles, 6 home runs and 22 RBIs and Alec Burleson’s added 59 hits with 10 doubles, 5 home runs and 21 RBIs.

Why the St. Louis Cardinals will win

– The White Sox have lost each of their last 12 night games against National League opponents that held a winning record.
– The Cardinals have won seven of their last eight road games against AL Central opponents following a loss.
– The Cardinals have covered the run line in each of their last eight road games following a road loss.
– The White Sox have failed to cover the run line in each of their last four games as underdogs against NL Central opponents.

St. Louis Cardinals Player Prop Facts

– Willson Contreras has hit a home run in two of the Cardinals’ last three road games against AL Central opponents that held a losing record.
– Willson Contreras has recorded at least one RBI in each of the Cardinals’ last eight games against AL opponents.
– Brendan Donovan has scored at least one run in eight of his last nine appearances after not playing the previous day.
– Willson Contreras has recorded at least one hit in each of the Cardinals’ last 10 games as favorites.
– Lars Nootbaar has recorded a Double in four of the Cardinals’ last five night games against AL opponents that held a losing record.
– Victor Scott II ranks T8th in the league in Steals (19) this season.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to rebound from their 2-1 loss at the hands of the Texas Rangers last time out to sit at 23-49 on the year. After this series, the White Sox will head on the road for a game against the Toronto Blue Jays.

White Sox Lose Five In A Row

Lenyn Sosa has 55 hits including 10 doubles and 17 RBIs. Andrew Benintendi has 38 hits including 6 home runs, 23 RBIs and a .235 batting average while Miguel Vargas has a team-high 61 hits, 18 doubles, 10 home runs and 31 RBIs. Brooks Baldwin has also added 16 RBIs while Luis Robert Jr. has a team-high 21 stolen bases along with 28 RBIs so far this season. Andrew Vaughn has 5 home runs and 19 RBIs as well as 8 doubles this season.

Why the Chicago White Sox will win

– The Cardinals have lost each of their last four games as favorites.
– The White Sox have won eight of their last 10 games as home underdogs following a loss.
– The Cardinals have failed to cover the run line in each of their last seven games against American League opponents.
– The underdogs have covered the run line in each of the Cardinals’ last seven games.

Chicago White Sox Player Prop Facts

– Miguel Vargas has hit at least one home run in seven of his last nine appearances against NL Central opponents that held a winning record.
– Miguel Vargas has recorded a Double in each of the White Sox’s last three games against NL opponents.
– Miguel Vargas has recorded at least one RBI in eight of his last nine appearances against NL Central opponents that held a winning record.
– Miguel Vargas has scored at least one run in each of the White Sox’s last four games.
– Luis Robert has recorded at least one hit in each of his nine previous appearances in night games against NL Central teams that held a winning record.
– Luis Robert ranks T4th in the league in Steals (21) this season.

Total Runs Facts

– Each of the Cardinals’ last nine night games against American League opponents have gone OVER the total runs line.
– Four of the White Sox’s last five games as underdogs against the Cardinals have gone UNDER the total runs line.

St. Louis Cardinals vs. Chicago White Sox Prediction

I’m on the under here. I just see two lineups that I don’t trust offensively in their current form. I’d make a strong argument that I think the White Sox could end up getting to Liberatore before St. Louis gets to Smith. However, this is still the Chicago White Sox we’re talking about and I think we have another low-scoring kind of game so give me the under here.

Chris Ruffolo's Pick: Under 8.5

Need More? Get Premium Picks

Hot Cappers this week

Latest Picks & Game Previews

  • Carlos Alcaraz vs Taylor Fritz Prediction 07/11/2025 Wimbledon Picks

    July 11, 2025

  • Jannik Sinner vs Novak Djokovic Prediction 07/11/2025 Wimbledon Picks

    July 11, 2025

  • Chicago Cubs vs New York Yankees Prediction 07/11/2025 Picks

    July 11, 2025

  • MLB Player Prop Picks 07/11/2025 Picks (American League Pitchers)

    July 11, 2025

  • Seattle Mariners vs Detroit Tigers Prediction 07/11/2025 Picks

    July 11, 2025

  • Rays vs Red Sox Prediction 07/11/2025 Picks

    July 11, 2025

  • Pittsburgh Pirates vs Minnesota Twins Prediction 07/11/2025 Picks

    July 11, 2025

  • Mets vs Royals Prediction 07/11/2025 Picks

    July 11, 2025

  • Guardians vs White Sox Prediction 07/11/2025 Picks

    July 11, 2025

  • MLB Player Prop Picks 07/11/2025 Picks (National League Pitchers)

    July 11, 2025