Chicago White Sox vs Seattle Mariners Prediction 5/19/2026 Today’s MLB Picks

The Chicago White Sox and the Seattle Mariners meet Tuesday in MLB action from T-Mobile Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs. Seattle Mariners prediction.

Starting Pitching Matchup

The Chicago White Sox will send out Anthony Kay for the start here and Kay is 3-1 with a 4.61 ERA and 29 strikeouts this season. This will be Kay’s second career start against the Mariners. Bryce Miller will start here for Seattle and is 0-0 with a 3.38 ERA and 3 strikeouts this season. In his career, Miller is 2-0 with a 1.77 ERA and 20 strikeouts against the White Sox.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to bounce back from their 6-1 loss at the hands of the Mariners from Monday’s series opener to sit at 24-23 this season. After this series, the White Sox will head on the road for a series against the San Francisco Giants.

White Sox Have Two-Game Win Streak Halted

Entering Monday, Munetaka Murakami has 38 hits with 17 home runs and 32 RBIs while Miguel Vargas has 40 hits with 7 doubles, a triple, 11 home runs and 29 RBIs and Colson Montgomery has 39 hits with 8 doubles, 13 home runs and 31 RBIs. Luisangel Acuna has 15 hits and Tristan Peters has 27 hits with 4 doubles so far this season. Chase Meidroth also has 43 hits with 9 doubles, 3 home runs and 10 RBIs this year.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to add on to their win over the White Sox from Monday to improve to 23-26 this season. After this series, the Mariners will head on the road for a series against the Kansas City Royals.

Mariners Snap Three-Game Skid

Going into Monday, Luke Raley has 10 home runs and 27 RBIs this season. Cole Young’s added 42 hits with 8 doubles, a triple, 3 home runs and 26 RBIs and Cal Raleigh has 26 hits with 4 doubles, 7 home runs and 18 RBIs as well this season. Randy Arozarena has 52 hits with 11 doubles, 4 home runs and 18 RBIs as well on the year. Josh Naylor also has 44 hits with 5 home runs and 20 RBIs as well on the year. Julio Rodriguez has also added 48 hits with 9 doubles, 7 home runs and 20 RBIs.

The Chicago White Sox @ Seattle Mariners Betting Trends: May 19, 2026

• Probable Starting Pitcher: Bryce Miller      Record this season: 0-0      ERA: 3.38
• Home Record: 0-0
• Last 5 against White Sox: 2-0

Why the Seattle Mariners will win

• The Mariners have won eight of their last nine home games against the White Sox.
• The White Sox have lost each of their last six games at T-Mobile Park against teams that held a losing record.
• The Mariners have covered the run line each of their last five home games against AL Central opponents that held a winning record.
• The White Sox have failed to cover the run line in 10 of their last 11 night games against American League opponents following a road loss.
• The Mariners have won the first inning in each of their last three games against American League opponents.
• The Mariners have led after 3 innings in five of their last six games against American League opponents.
• The Mariners have led after 5 innings in each of their last six games against American League opponents.

• Probable Starting Pitcher: Anthony Kay      Record this season: 3-1      ERA: 4.61
• Road Record: 1-1
• Last 5 against Mariners: 1-0

Why the Chicago White Sox will win

• The White Sox have won each of their last five games as road underdogs following a loss.
• The Mariners have lost each of their last four games as home favorites following a win.
• The Mariners have failed to cover the run line in each of their last six night games at T-Mobile Park following a win.
• The White Sox have covered the run line in each of their last five games as road underdogs following a loss.
• The Mariners have lost the first inning in three of their last four night games against American League opponents that held a winning record.
• The White Sox have led after 3 innings in four of their last five games as road underdogs against American League opponents.
• The White Sox have led after 5 innings in four of their last five games as road underdogs against American League opponents.

Total Runs Facts

• Six of the White Sox’s last seven games have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Mariners’ last 14 games as home favorites against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 10 of the White Sox’s last 11 games as underdogs.

Seattle Mariners Player Prop Facts

• Bryce Miller has recorded five or more strikeouts in 11 of his last 13 appearances with the Mariners as home favorites against AL opponents.
• Julio Rodriguez has recorded at least one hit in each of the Mariners’ last 14 home games against AL opponents.
• Cal Raleigh has hit a home run in three of his last four home appearances against AL opponents.
• Josh Naylor ranks T8th in the league in Steals (12) this season.

Chicago White Sox Player Prop Facts

• Austin Hays has hit a home run in two of his last three appearances against the Mariners.
• Austin Hays has recorded at least one hit in 10 of his last 11 appearances with his team as an underdog against AL opponents.
• Munetaka Murakami ranks 2nd in the league in Home Runs (17) this season.

Matchup/League Facts

• The Mariners rank 1st in the league for walks allowed this season (125).
• The Mariners rank 28th in the league for doubles this season (64).
• The White Sox rank 30th in the league for doubles this season (56).
• The White Sox rank 2nd in the league for home runs this season (67).

Chicago White Sox vs. Seattle Mariners Prediction

I’m on the White Sox here. I just think that this is probably the most winnable spot of the series for the White Sox as I’m not buying into Miller after one start and while he didn’t look great in April, Kay has started to turn things around a bit as of late and I think that this ends up being a solid start as the Mariners have stunk it up against lefties. Give me the White Sox.

Chris Ruffolo's Pick: Chicago White Sox +125