Chicago White Sox vs Seattle Mariners Prediction 5/18/2026 Today’s MLB Picks

In this article, we will formulate a White Sox vs Mariners Prediction for this MLB matchup on Monday, May 18th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Preview

The Seattle Mariners have a 22-26 record this season and are sitting in the third place of the AL West. They have a 12-14 home record and are coming off a 8-3 loss against the Padres. They will face the Royals and the Athletics next.

The Mariners have a .228 batting average this season, .319 OBP and .376 Slugging percentage. Seattle’s pitching staff has a 3.75 ERA and 1.23 WHIP. Randy Arozarena is the team’s best hitter with a .301 batting average. Luke Raley leads the team in RBI with 27. Luke Raley adds a team high 10 home runs.

Bryan Woo (R) is the projected starting pitcher for the Mariners, and he has a 3-2 record, 3.91 ERA and 1.00 WHIP.

Chicago White Sox Preview

The Chicago White Sox have a 24-22 record this season and are sitting in the second place of the AL Central. They have a 10-12 away record and are coming off a 9-8 win against the Cubs. They will face the Giants and the Twins next.

The White Sox have a .236 batting average this season, .325 OBP and .412 Slugging percentage. Chicago’s pitching staff has a 4.35 ERA and 1.38 WHIP. Chase Meidroth is the team’s best hitter with a .262 batting average. Munetaka Murakami leads the team in RBI with 32. Munetaka Murakami adds a team high 17 home runs.

Noah Schultz (L) is the projected starting pitcher for the White Sox, and he has a 2-2 record, 4.91 ERA and 1.36 WHIP.

The Chicago White Sox @ Seattle Mariners Betting Trends: May 18, 2026

• Probable Starting Pitcher: Bryan Woo      Record this season: 3-2      ERA: 3.91
• Home Record: 2-0
• Last 5 against White Sox: 1-0

Why the Seattle Mariners will win

• The Mariners have won each of their last six games against the White Sox following a home loss.
• The White Sox have lost seven of their last eight games at T-Mobile Park.
• The Mariners have covered the run line each of their last four home games against AL Central opponents that held a winning record.
• The White Sox have failed to cover the run line in each of their last four games as road underdogs against the Mariners following a win.
• The Mariners have led after 5 innings in seven of their last eight games as favorites against American League opponents.
• The Mariners have led after 3 innings in four of their last five games against American League opponents.

• Probable Starting Pitcher: Noah Schultz      Record this season: 2-2      ERA: 4.91
• Road Record: 2-1
• Last 5 against Mariners: –

Why the Chicago White Sox will win

• The White Sox have won nine of their last 10 games as underdogs against American League opponents.
• The Mariners have lost four of their last five games as favorites.
• The White Sox have covered the run line in each of their last nine games against American League opponents following a home win.
• The Mariners have failed to cover the run line each of their last seven night games against teams that held a winning record.
• The White Sox have led after 3 innings in each of their last four games as road underdogs against American League opponents.
• The Mariners have lost the first inning in four of their last five night games against American League opponents that held a winning record.
• The White Sox have led after 5 innings in each of their last four games as road underdogs against American League opponents.

Total Runs Facts

• Each of the White Sox’s last six games have gone OVER the total runs line.
• Five of the Mariners’ last six night games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Mariners’ last 13 games as home favorites against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the White Sox’s last 10 games as underdogs.

Seattle Mariners Player Prop Facts

• Julio Rodriguez has recorded at least one hit in each of the Mariners’ last 13 home games against AL opponents.
• Cal Raleigh has hit a home run in three of his last four home appearances against AL opponents.
• Randy Arozarena ranks T8th in the league in Steals (12) this season.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit a home run in each of the White Sox’s last two games as road underdogs against AL opponents.
• Miguel Vargas has recorded at least one hit in each of the White Sox’s last 19 games as underdogs.
• Munetaka Murakami ranks 2nd in the league in Home Runs (17) this season.

Matchup/League Facts

• The Mariners rank 1st in the league for walks allowed this season (122).
• The Mariners rank 27th in the league for doubles this season (62).
• The White Sox rank 30th in the league for doubles this season (56).
• The White Sox rank T2nd in the league for home runs this season (66).

White Sox vs Mariners Prediction

The Mariners are 7-3 in their last 10 meetings against the White Sox and have won their last three meetings in Seattle.

In this White Sox vs Mariners Prediction, the Mariners are coming as -180 home favorites. The White Sox have been red-hot lately with a 7-1 record in their last 8 games while the Mariners got swept by the Padres at home by 0-3 wins. The Mariners have been terrible against lefties and dead last against southpaws in the last couple of weeks and Woo has been up and down lately, so there is huge value with the road dog in this spot. I will take a stab with the White Sox on the moneyline for good plus money.

Nikos Lagouretos's Pick: Chicago White Sox ML