Chicago White Sox vs Seattle Mariners Prediction 08/06/2025 Today’s MLB Picks

The Chicago White Sox and the Seattle Mariners meet Wednesday in MLB action from T-Mobile Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs. Seattle Mariners prediction.

Starting Pitching Matchup

The Chicago White Sox will trot out Jonathan Cannon for the start here and Cannon is 4-8 with a 4.77 ERA and 75 strikeouts this season. This will be Cannon’s second career start against the Mariners. The Seattle Mariners will start George Kirby here and Kirby is 6-5 with a 4.13 ERA and 74 strikeouts this season. In his career, Kirby is 1-0 with a 2.13 ERA and 16 strikeouts against the White Sox.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to rebound from their 8-3 loss at the hands of the Mariners on Tuesday to sit at 42-71 on the year. After this series, the White Sox will head home for a series against the Cleveland Guardians.

White Sox Drop Back-To-Back Games

Lenyn Sosa has 96 hits including 16 doubles and 44 RBIs. Andrew Benintendi has 68 hits including 13 doubles, 14 home runs, 43 RBIs and a .231 batting average while Miguel Vargas has 90 hits, 25 doubles, 13 home runs and 44 RBIs. Brooks Baldwin has also added 24 RBIs while Luis Robert Jr. has a team-high 29 stolen bases along with 46 RBIs so far this season. Chase Meidroth has added 78 hits with 11 stolen bases as well as 12 doubles this season.

Why the Chicago White Sox will win

• The Mariners have lost six of their last eight games as favorites following a win.
• The White Sox have won three of their last four games as road underdogs against American League opponents following a loss.
• The Mariners have failed to cover the run line in each of their last nine Wednesday night games against AL Central opponents.
• The White Sox have covered the run line in 12 of their last 13 games at T-Mobile Park following a road loss.

Chicago White Sox Player Prop Facts

• Luis Robert has hit a home run in four of the White Sox’s last five road games against the Mariners.
• Luis Robert has recorded at least one hit in each of his last 12 appearances in night games.
• Luis Robert ranks T6th in the league in Steals (29) this season.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to add on to their 8-3 win over the White Sox last time out to sit at 61-53 on the year. After this series, the Mariners will take on the Tampa Bay Rays in a series at home.

Mariners Win 4 Of Their Last 5

Jorge Polanco has 82 hits including 18 home runs and 53 RBIs while Cal Raleigh has 104 hits with 16 doubles, a team-high 42 home runs and 88 RBIs. Randy Arozarena has 103 hits with 24 doubles, 22 home runs, 55 RBIs and 21 stolen bases. Julio Rodriguez also has 119 hits with 19 doubles, 3 triples, 20 home runs, 59 RBIs and 21 stolen bases. Dylan Moore has 9 homers and 12 stolen bases as well this season. J.P Crawford has 109 hits with 17 doubles, 9 home runs and 44 RBIs.

Why the Seattle Mariners will win

• The White Sox have lost each of their last six games against AL West opponents following a road loss.
• The Mariners have won each of their last five night games at T-Mobile Park following a win.
• The Mariners have covered the run line in each of their last four games against AL Central opponents.
• The White Sox have failed to cover the run line in five of their last six games against the Mariners following a loss.

Seattle Mariners Player Prop Facts

• Julio Rodriguez has hit a home run in three of the Mariners’ last four games against AL Central opponents.
• George Kirby has recorded a win in each of his last four appearances against AL opponents.
• Victor Robles has recorded a Double in three of his last four appearances against AL Central opponents.
• Victor Robles has recorded at least one hit in each of his last eight appearances.
• Cal Raleigh ranks 1st in the league in Home Runs (42) this season.

Total Runs Facts

• Nine of the Mariners’ last 10 night games after playing the previous day have gone UNDER the total runs line.

Chicago White Sox vs. Seattle Mariners Prediction

I’m on the Mariners here. I think that the White Sox were in a nice run of form but at a certain point for some teams, the value comes to an end and I think we’re at that point with Chicago. Seattle came out strong in Tuesday’s matchup and the Mariners have an even bigger edge in starting pitching with Kirby going here over Jonathan Cannon who has been hit hard in a couple of his recent outings. I think Seattle picks up another sizeable win here so give me Seattle.