Chicago White Sox vs New York Yankees Prediction 9/25/2025 Today’s MLB Picks

The Chicago White Sox and New York Yankees meet on Thursday in MLB action from Yankee Stadium. Here’s a Chicago White Sox vs New York Yankees prediction. We will look at this from a betting perspective and determine the best Yankees vs White Sox pick. We will examine:

The Chicago White Sox’ recent form and player performance

The New York Yankees’ recent form and player performance

Recent betting trends and streaks involving the White Sox

Recent betting trends and streaks involving the Yankees

Recent betting trends in games played between the Yankees and White Sox

A summary that ties it all together and produces a favorable betting outcome for the White Sox and Yankees game.

White Sox Lose Again

As has often been the case, the White Sox lost another game on Wednesday, and the pitching was awful. The White Sox actually scored the first run in the top of the second inning, and then failed to score one the rest of the game. By the end of the third inning they were down 5-1 and they ended up losing 8-1. Jonathan Cannon went 4.1 innings giving up six hits and five runs. The bullpen also wasn’t good enough, something thath as far too often this season been the issue. 

The White Sox are averaging 3.95 runs while their pitching is giving up 4.55 runs per game. The offense is ranked 21st while the pitching is ranked 21st. As a team they are averaging one home run per game which is 23rd in baseball. Getting the start for the White Sox will be Davis Martin who sits with a 7-10 record and an ERA of 4.03. Against the San Diego Padres in his last start he went six innings giving up six hits and three runs. 

Why the White Sox Will Beat the Yankees

• The White Sox have won four of their last five night games against the Yankees at Yankee Stadium following a road loss.
• The Yankees have failed to cover the run line in six of their last seven games as home favorites against American League opponents following a win.
• The White Sox have covered the run line in six of their last seven night games against the Yankees at Yankee Stadium following a loss.

Yankees Continue to Climb

Don’t look now, but the Yankees are tied for first place in the American League East, and this really is a must win for them. On Wednesday, the Yankees scored eight runs, and ended up cruising to the win. Aaron Judge can’t be stopped and he hit two home runs while driving in four RBIs to help pace the offense. 

The Yankees are averaging 5.22 runs while their pitching is giving up 4.29 runs per game. The offense is ranked 1st while the pitching is ranked 15th. They have a run differential of 0.92 which is 2nd best in the league. Getting the start for the Yankees will be Carlos Rodon who sits with a 17-9 record and an ERA of 3.04. Against the Orioles in his last start he went seven innings giving up four hits and one run. Two starts ago against the Minnesota Twins, he went six innings giving up five hits and two runs. 

Why the Yankees Will Beat the White Sox

• The White Sox have lost each of their last eight games against American League opponents.
• The Yankees have won nine of their last 10 home games against teams that held a losing record.
• The White Sox have failed to cover the run line in each of their last eight night games against American League opponents following a road loss.
• The Yankees have covered the run line in five of their last six games as home favorites against the White Sox.
• The Yankees have led after 5 innings in nine of their last 10 home games against opponents that held a losing record.
• The White Sox have trailed after 3 innings in four of their last five road night games.

Chicago White Sox vs New York Yankees Prediction

The Yankees are going to put on a show here with the pitching. Carolos Rodon has been impressive heading into this game and each of his last two starts he has really stepped up. In his last start against the Orioles he went seven innings giving up four hits and one run. The White Sox bats are going to really struggle to get any sort of offense going here. For the Yankees, they are the top offense in all of baseball and they are going to tee off on Davis Martin. This game is going to be a blowout win by the Yankees. Back the Yankees -1.5 to cash.