Chicago White Sox vs New York Yankees Prediction 9/23/2025 Today’s MLB Picks

The Chicago White Sox and New York Yankees meet Tuesday in MLB action at Yankee Stadium. Here’s a Chicago White Sox vs New York Yankees Prediction. This article will include a Chicago White Sox vs New York Yankees Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 68-98 on the year and play the Nationals next. The Chicago White Sox are batting .232 on the season, have a .302 OBP, and a .372 slugging percentage. The Chicago White Sox pitching staff has a 4.23 ERA and a 1.36 WHIP. Lenyn Sosa leads the Chicago White Sox with 129 hits and 71 RBI, while Chase Meidroth and Miguel Vargas have combined for 223 hits and 80 RBI.

Shane Smith gets the ball for the Chicago White Sox, and he is 6-8 with a 4.06 ERA and 129 strikeouts this season. This will be Smith’s second career game against the New York Yankees.

New York Yankees Betting Preview

The New York Yankees are 88-68 on the year and play the Orioles next. The New York Yankees are batting .250 on the season, have a .330 OBP, and a .454 slugging percentage. The New York Yankees pitching staff has a 3.97 ERA and a 1.26 WHIP. Aaron Judge leads the New York Yankees with 170 hits and 105 RBI while Cody Bellinger and Paul Goldschmidt have combined for 286 hits and 141 RBI.

Luis Gil gets the ball for the New York Yankees, and he is 4-1 with a 3.33 ERA and 36 strikeouts this season. Gil is 1-1 with a 5.12 ERA and 29 strikeouts in his career against the Chicago White Sox.

The Chicago White Sox @ New York Yankees Betting Trends: September 23, 2025

• Probable Starting Pitcher: Luis Gil      Record this season: 4-1      ERA: 3.33
• Home Record: 2-0
• Last 5 against White Sox: 1-1

Why the New York Yankees will win

• The White Sox have lost eight of their last nine games.
• The Yankees have won seven of their last eight home games against teams that held a losing record.
• The Yankees have covered the run line in seven of their last eight games at Yankee Stadium against teams that held a losing record.
• The White Sox have failed to cover the run line in seven of their last eight night games against American League opponents following a loss.
• The White Sox have trailed after 5 innings in each of their last five games at Yankee Stadium against opponents that held a winning record.
• The White Sox have lost the first inning in three of their last four night games against AL East opponents that held a winning record.

• Probable Starting Pitcher: Shane Smith      Record this season: 6-8      ERA: 4.06
• Road Record: 3-4
• Last 5 against Yankees: 0-0

Why the Chicago White Sox will win

• The Yankees have lost each of their last three games as home favorites following a road win.
• The White Sox have won each of their last five night games at Yankee Stadium following a loss.
• The Yankees have failed to cover the run line in seven of their last eight home games against American League opponents following a win.
• The White Sox have covered the run line in seven of their last eight night games against the Yankees at Yankee Stadium following a loss.

Total Runs Facts

• Eight of the White Sox’s last nine games as underdogs have gone UNDER the total runs line.
• Each of the Yankees’ last four games as favorites have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last six games as underdogs against AL East opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the last five games between the White Sox and Yankees.

New York Yankees Player Prop Facts

• Giancarlo Stanton has hit a home run in four of his last five appearances at Yankee Stadium against opponents that held a losing record.
• Aaron Judge has recorded at least one hit in each of his last 11 home appearances against the White Sox.
• Paul Goldschmidt has recorded a Double in four of his last five appearances at Yankee Stadium against opponents that held a losing record.

Chicago White Sox Player Prop Facts

• Michael A. Taylor has hit a home run in two of his last three appearances against the Yankees after not playing the previous day.
• Andrew Benintendi has recorded at least one hit in each of his last six appearances against the Yankees.

Chicago White Sox vs New York Yankees Prediction

Smith has been great this season, but it looks like he may have hit the rookie wall, allowing 19 hits and 12 runs in his last 21.1 innings. In 64.2 road innings, Smith has a 4.59 ERA and .238 allowed batting average, which is a drop from his home splits. The White Sox as a team recently look like, well, how the White Sox usually look. The Yankees are at home and two games out of the AL East. There are no excuses not to win this game and the series. I’ll roll with the Yankees on Tuesday night.