Chicago White Sox vs New York Yankees Prediction 6/17/2026 Today’s MLB Picks

The Chicago White Sox and New York Yankees meet Wednesday in MLB action at Comerica Park. Here’s a Chicago White Sox vs New York Yankees Prediction. This article will include a Chicago White Sox vs New York Yankees Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 38-33 on the year and play the Guardians and Tigers next. The Chicago White Sox are batting .239 on the season, have a .323 OBP, and have a .410 slugging percentage. The Chicago White Sox pitching staff has a 4.39 ERA and a 1.33 WHIP. Chase Meidroth leads the Chicago White Sox with 71 hits and 25 RBI, while Colson Montgomery and Miguel Vargas have combined for 117 hits and 84 RBI.

Anthony Kay gets the ball for the Chicago White Sox, and he is 6-1 with a 4.34 ERA and 53 strikeouts this season. Kay is 0-0 with a 7.71 ERA and 8 strikeouts in his career against the New York Yankees.

New York Yankees Betting Preview

The New York Yankees are 44-27 on the year and play the Reds and Tigers next. The New York Yankees are batting .245 on the season and have a .332 OBP and a .438 slugging percentage. The New York Yankees’ pitching staff has a 3.30 ERA and a 1.18 WHIP. Ben Rice leads the New York Yankees with 71 hits and 49 RBI, while Cody Bellinger and Jazz Chisholm Jr. have combined for 126 hits and 76 RBI.

Carlos Rodon gets the ball for the New York Yankees, and he is 2-2 with a 3.19 ERA and 34 strikeouts this season. Rodon is 3-0 with a 3.00 ERA and 16 strikeouts in his career against the Chicago White Sox.

Why the New York Yankees will win

• The White Sox have lost each of their last nine night games against AL East opponents that held a winning record.
• The Yankees have won each of their last eight night games against the White Sox following a win.
• The White Sox have failed to cover the run line in each of their last six games as underdogs against AL East opponents.
• The Yankees have covered the run line in seven of their last eight games as home favorites against the White Sox.
• The Yankees have led after 3 innings in three of their last four games against the White Sox at Yankee Stadium.
• The Yankees have led after 5 innings in seven of their last eight games against the White Sox.

Why the Chicago White Sox will win

• The White Sox have won eight of their last nine games as road underdogs following a loss.
• The Yankees have lost three of their last four games as home favorites following a win.
• The Yankees have failed to cover the run line in each of their last eight games as home favorites after playing the previous day.
• The White Sox have covered the run line in eight of their last nine games as road underdogs following a loss.

Total Runs Facts

• Five of the White Sox’s last six games as underdogs against American League opponents have gone OVER the total runs line.
• Four of the Yankees’ last five games against American League opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the White Sox’s last eight games as underdogs.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of Carlos Rodon’s last 10 appearances as a starter.

New York Yankees Player Prop Facts

• Carlos Rodon has recorded seven or more strikeouts in six of his seven previous appearances at Yankee Stadium against AL Central opponents that held a winning record.
• Trent Grisham has recorded at least one hit in each of his last seven appearances against AL opponents.
• Carlos Rodon has recorded a win in each of his three previous appearances with the Yankees as favorites against the White Sox.
• Aaron Judge has hit at least one home run in four of his last five appearances in night games against AL Central teams that held a winning record.
• Ben Rice ranks T4th in the league in Home Runs (20) this season.

Chicago White Sox Player Prop Facts

• Andrew Benintendi has recorded at least one hit in each of his last seven appearances with the White Sox as underdogs against the Yankees.
• Andrew Benintendi has hit a home run in each of the White Sox’s last three games as road underdogs against AL opponents.

Matchup/League Facts

• The Yankees rank 2nd in the league for slugging percentage this season (.438).
• The Yankees rank 2nd in the league for walks this season (306).
• The White Sox rank 25th in the league for hits this season (563).
• The White Sox rank 25th in the league for strikeouts against this season (644).

Chicago White Sox vs New York Yankees Prediction

The Yankees are going to be favored at home because they’re the Yankees. Rodon is also a quality name on the bump. However, I keep saying it: the White Sox are a good team that still doesn’t get respect from oddsmakers, but they continue to win and cash tickets. In fact, only the Nationals and Cardinals have earned more money this season than the White Sox. We’re getting 1.5 times our money with the White Sox. I’ll take it.

Randy Chambers's Pick: Chicago White Sox