May 4, 2026; Anaheim, California, USA;  Chicago White Sox left fielder Sam Antonacci (17) talks with first baseman Munetaka Murakami (5) in the dugout after defeating the Los Angeles Angels at Angel Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images
Jayne Kamin-Oncea-Imagn Images

Chicago White Sox vs Los Angeles Angels Prediction 5/5/2026 Today’s MLB Picks

Pick details

MATCHUP Chicago White Sox Los Angeles Angels
Team Records 17-18 13-23
Spread -1.5 140 +1.5 -170
Moneyline -108 -112
Total Over 9 (-110) Under 9 (-110)
Where Angel Stadium, Anaheim, California
When Tuesday, May 5, 2026
Time 09:38 PM EDT
TV ESPN Unlmtd

The Chicago White Sox and Los Angeles Angels meet Tuesday in MLB action at Dodger Stadium. Here’s a Chicago White Sox vs. Los Angeles Angels Prediction. This article will include a Chicago White Sox vs. Los Angeles Angels Pick.

Chicago White Sox Betting Preview


The Chicago White Sox are 17-18 on the year and play the Mariners and Royals next. The Chicago White Sox are batting .231 on the season, have a .323 OBP, and have a .387 slugging percentage. The Chicago White Sox pitching staff has a 4.13 ERA and a 1.37 WHIP. Chase Meidroth leads the Chicago White Sox with 33 hits and 4 RBI, while Miguel Vargas and Munetaka Murakami have combined for 58 hits and 46 RBI.

Erick Fedde gets the ball for the Chicago White Sox, and he is 0-3 with a 3.24 ERA and 22 strikeouts this season. Fedde is 0-0 with a 1.29 ERA and 12 strikeouts in his career against the Los Angeles Angels.

Los Angeles Angels Betting Preview


The Los Angeles Angels are 13-23 on the year and play the Blue Jays and Guardians next. The Los Angeles Angels are batting. 232 on the season, have a .323 OBP, and have a .382 slugging percentage. The Los Angeles Angels pitching staff has a 4.58 ERA and a 1.44 WHIP. Jo Adell leads the Los Angeles Angels with 39 hits and 20 RBI while Mike Trout and Nolan Schanuel have combined for 64 hits and 40 RBI.

The Los Angeles Angels didn’t announce a starting pitcher at the time this article was published.

Why the Los Angeles Angels will win

  • The White Sox have lost seven of their last eight night games against AL West opponents following a road win.
  • The Angels have won three of their last four home games against AL Central opponents following a home loss.
  • The White Sox have failed to cover the run line in six of their last eight night games against AL West opponents following a road win.
  • The Angels have covered the run line in three of their last four home games against AL Central opponents following a home loss.
  • The White Sox have trailed after 5 innings in three of their last four road games against American League opponents that held a losing record.

Why the Chicago White Sox will win

  • The Angels have lost each of their last eight games against AL Central opponents.
  • The White Sox have won each of their last four games as underdogs against AL West opponents.
  • The underdogs have covered the run line in 15 of the White Sox’s last 16 games.
  • The Angels have failed to cover the run line in nine of their last 10 games as favorites against American League opponents.
  • The Angels have trailed after 3 innings in each of their last three games as favorites against American League opponents.
  • The Angels have trailed after 5 innings in five of their last six night games against AL Central opponents.

Total Runs Facts

  • Nine of the Angels’ last 10 home games have gone UNDER the total runs line.
  • Each of the White Sox’s last four road games after playing the previous day has gone UNDER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Angels’ last four home games.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the White Sox’s last six games as underdogs.

Los Angeles Angels Player Prop Facts

  • Jo Adell has recorded at least one hit in each of the Angels’ last eight games against AL Central opponents.
  • Logan O’Hoppe has hit a home run in three of his last five appearances at Angel Stadium of Anaheim against AL Central opponents that held a losing record.

Chicago White Sox Player Prop Facts

  • Miguel Vargas has hit a home run in each of the White Sox’s last two games as road underdogs against AL opponents.
  • Miguel Vargas has recorded at least one hit in each of his last 10 appearances against AL West opponents that held a losing record.

Matchup/League Facts

  • The Angels rank 26th in the league for runs allowed this season (179).
  • The Angels rank T25th in the league for doubles this season (48).
  • The White Sox rank T5th in the league for triples this season (6).
  • The White Sox rank 25th in the league for hits this season (268).

Chicago White Sox vs Los Angeles Angels Prediction


It would be nice to know who the Angels are throwing on the mound but who cares? The Angels are looking more and more like teams from past seasons and they’re not a team I’m excited to back. The White Sox are competing and winning, and Fedde has looked solid with a 3.24 ERA and 1.05 WHIP. The Angels are getting respect in the betting market and I don’t get it. This team is awful. Give me the White Sox and the pick ’em price.

Randy Chambers's Pick: Chicago White Sox

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