Chicago White Sox vs Chicago Cubs Prediction 07/26/2025 Picks

The Chicago Cubs and the Chicago White Sox meet Saturday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago Cubs vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Chicago Cubs will send out Cade Horton for the start here and Horton is 3-3 with a 4.04 ERA and 47 strikeouts this season. This will be Horton’s second career start against the White Sox. The Chicago White Sox will send out Aaron Civale for the start here and Civale is 2-6 with a 4.76 ERA and 42 strikeouts this season. In his career, Civale is 0-0 with a 1.61 ERA and 16 strikeouts against the Cubs.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to rebound from a 12-5 loss at the hands of the White Sox in Friday’s series opener to sit at 60-43 on the year. After this series, the Cubs will head on the road for a huge division series against the Milwaukee Brewers.

Cubs Lose 4 Of Their Last 5 Games

Ian Happ has 83 hits with 16 doubles, 13 home runs and 48 RBIs. Kyle Tucker has 103 hits including 19 doubles, 4 triples, 18 home runs and 58 RBIs while Seiya Suzuki also has 100 hits with 24 doubles and 26 home runs and 81 RBIs of his own. Pete Crow-Armstrong also has contributed 106 hits, 25 doubles, 4 triples, 27 home runs and 74 RBIs as well this season. Dansby Swanson has added 16 home runs and 47 RBIs, while also having 115 strikeouts and Suzuki has a team-high 114 strikeouts so far this season. Crow-Armstrong also has a team-high 28 stolen bases while Nico Hoerner has 19 stolen bases this season. Tucker’s also added 23 stolen bases while Michael Busch has also chipped in 15 doubles, 3 triples, 20 home runs and 60 RBIs this season.

Why the Chicago Cubs will win

• The White Sox have lost 19 of their last 20 night games against National League opponents that held a winning record.
• The Cubs have won eight of their last nine games against the White Sox.
• The Cubs have covered the run line in each of their last seven games as road favorites against American League opponents following a road loss.
• The White Sox have failed to cover the run line each of their last seven Saturday night games against teams that held a winning record.

Chicago Cubs Player Prop Facts

• Kyle Tucker has hit a home run in each of his last four Saturday night appearances with his team as a favorite.
• Nico Hoerner has recorded at least one hit in each of the Cubs’ last 10 games as road favorites.
• Pete Crow-Armstrong ranks 5th in the league in Steals (28) this season.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to add on to their win over the Cubs from Friday’s matchup to sit at 38-66 this season. After this series, the White Sox will square off against the Philadelphia Phillies at home.

White Sox Win 6 Of Their Last 7 Games

Lenyn Sosa has 83 hits including 16 doubles and 37 RBIs. Andrew Benintendi has 62 hits including 12 doubles, 11 home runs, 38 RBIs and a .235 batting average while Miguel Vargas has 84 hits, 25 doubles, 12 home runs and 41 RBIs. Brooks Baldwin has also added 24 RBIs while Luis Robert Jr. has a team-high 26 stolen bases along with 41 RBIs so far this season. Chase Meidroth has added 75 hits with 11 stolen bases as well as 11 doubles this season.

Why the Chicago White Sox will win

• The White Sox have won each of their last five games as underdogs against National League opponents.
• The Cubs have lost three of their last four games as favorites.
• The White Sox have covered the run line in each of their last eight games.
• The Cubs have failed to cover the run line in six of their last seven night games against AL Central opponents.

Chicago White Sox Player Prop Facts

• Aaron Civale has recorded four or more strikeouts in each of his last eight appearances with his team as an underdog against NL opponents.
• Andrew Benintendi has recorded at least one hit in each of his last 10 appearances against NL Central opponents that held a winning record.
• Aaron Civale has recorded a win in three of his last four appearances against NL Central opponents.
• Austin Slater has hit a home run in each of the White Sox’s last two games as home underdogs.
• Michael A. Taylor has recorded a Double in each of his last five appearances with the White Sox as underdogs against NL opponents.
• Luis Robert ranks T8th in the league in Steals (26) this season.

Total Runs Facts

• Eight of the Cubs’ last nine road games against AL Central opponents have gone UNDER the total runs line.
• Each of the White Sox’s last four night games against NL Central opponents have gone OVER the total runs line.

Chicago Cubs vs. Chicago White Sox Prediction

I’m on the over in this one. I don’t trust either one of these starting pitching options in honesty, as the White Sox are playing their best ball of the season and Cade Horton doesn’t look major league ready, while the Cubs are still a strong team and Aaron Civale’s been prone to giving up home runs not just this season, but overall in his career. I think we get some runs here as well, so give me the over.