Jun 21, 2025; Denver, Colorado, USA; Arizona Diamondbacks second baseman Ketel Marte (4) scores a run in in the first inning against the Colorado Rockies at Coors Field. Mandatory Credit: Ron Chenoy-Imagn Images

Chicago White Sox vs Arizona Diamondbacks Prediction 06/24/2025 Picks

Pick details

Arizona (40-38) vs Chicago (25-54)

June 24, 2025 at 07:40 PM EDT

The Line: Betting Odds: Chicago +125 — Over/Under: +9

(Get latest betting odds)

The Arizona Diamondbacks and the Chicago White Sox meet Tuesday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Diamondbacks vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Arizona Diamondbacks will send out Ryne Nelson for the start here and Nelson is 4-2 with a 3.88 ERA and 45 strikeouts this season. This will be Nelson’s second career start against the White Sox. Jordan Leasure will start this one for the White Sox and is 2-4 with a 4.23 ERA and 34 strikeouts this season. This will be Leasure’s first career start against the White Sox.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to build on a 10-0 win to start the series on Monday to improve to 40-38 on the year. After this series, the Diamondbacks will take on the Miami Marlins in a series at home.

Diamondbacks Win 4 Of Their Last 5

Corbin Carroll has 73 hits with 20 home runs, 44 RBIs, 9 triples and 13 doubles while Josh Naylor has 87 hits with 18 doubles, 9 home runs and 51 RBIs as well this season. Eugenio Suarez has also added 25 home runs and 67 RBIs while Geraldo Perdomo has 52 RBIs. Naylor has also chipped in 10 stolen bases as well up to this point in the year while Suarez has the unfortunate distinction of leading the Diamondbacks with 82 strikeouts so far this season. Carroll also has 10 stolen bases and Perdomo has a team-high 11 stolen bases as well this season.

Why the Arizona Diamondbacks will win

The White Sox have lost each of their last 14 night games against National League opponents that held a winning record.
The Diamondbacks have won each of their last six games against AL Central opponents.
The Diamondbacks have covered the run line in each of their last nine Tuesday games against American League opponents.
The White Sox have failed to cover the run line in eight of their last nine night games against National League opponents that held a winning record.

Arizona Diamondbacks Player Prop Facts

Ketel Marte has hit a home run in seven of the Diamondbacks’ last eight games against AL Central opponents.
Ryne Nelson has recorded a win in each of his last three appearances with the Diamondbacks as favorites against AL Central opponents.
Ketel Marte has recorded at least one RBI in seven of the Diamondbacks’ last eight games against AL Central opponents.
Ryne Nelson has recorded five or more strikeouts in five of his last six appearances with the Diamondbacks as favorites against AL opponents.
Eugenio Suarez has recorded a Double in four of the Diamondbacks’ last five road games against AL Central opponents.
Josh Naylor has recorded at least one hit in each of his last 12 appearances.
Corbin Carroll has scored at least one run in each of his last 12 appearances with the Diamondbacks as favorites against AL Central opponents.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to rebound after taking one on the chin in Monday’s series opener to sit at 25-54 on the year. After this series, the White Sox will take on the San Francisco Giants at home.

White Sox Trying To Find Consistency

Lenyn Sosa has 61 hits including 12 doubles and 17 RBIs. Andrew Benintendi has 44 hits including 9 doubles, 8 home runs, 29 RBIs and a .239 batting average while Miguel Vargas has a team-high 67 hits, 20 doubles, 10 home runs and 34 RBIs. Brooks Baldwin has also added 16 RBIs while Luis Robert Jr. has a team-high 22 stolen bases along with 30 RBIs so far this season. Andrew Vaughn has 5 home runs and 19 RBIs as well as 8 doubles this season.

Why the Chicago White Sox will win

The White Sox have won each of their last five night games following a home loss.
The Diamondbacks have lost four of their last six games as road favorites following a win.
The White Sox have covered the run line in 11 of their last 12 games following a home loss.
The Diamondbacks have failed to cover the run line in five of their last six road games against American League opponents that held a losing record.

Chicago White Sox Player Prop Facts

Josh Rojas has hit a home run in two of his three previous home appearances against the Diamondbacks.
Andrew Benintendi has scored a run in each of his last five home appearances against NL opponents.
Korey Lee has recorded at least one hit in each of his last six appearances against NL opponents that held a winning record.
Luis Robert ranks T4th in the league in Steals (22) this season.

Total Runs Facts

Each of the Diamondbacks’ last seven night games against American League opponents have gone OVER the total runs line.
Five of the White Sox’s last six games as underdogs against National League opponents have gone OVER the total runs line.

Arizona Diamondbacks vs. Chicago White Sox Prediction

I’m on the Diamondbacks in this one. I just can’t get there with the White Sox In their current form as the Diamondbacks are the far better team and the far better team when it comes to hitting against right-handed pitching. The White Sox just can’t score right now and actually didn’t score in Monday’s opener. A similar showing wouldn’t shock me in the slightest here, but either way, I think the Diamondbacks pick up another win here so give me Arizona in this one.

Chris Ruffolo's Pick: Arizona -145

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