Aug 4, 2024; Chicago, Illinois, USA; Chicago Cubs outfielder Mike Tauchman (40) gestures after hitting a double against the St. Louis Cardinals during the fourth inning at Wrigley Field. Mandatory Credit: David Banks-Imagn Images

Chicago Cubs vs St. Louis Cardinals Prediction 06/23/2025 Picks

Pick details

Chicago (46-31) vs St. Louis (42-36)

June 23, 2025 at 07:45 PM EDT

The Line: Betting Odds: St. Louis +1.5 — Over/Under: +9

(Get latest betting odds)


The Chicago Cubs and St. Louis Cardinals meet Monday in MLB action at Busch Stadium. Here’s a Chicago Cubs vs St. Louis Cardinals Prediction. This article will include a Cardinals vs St. Louis Cardinals Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 46-31 on the year and play the Astros, Guardians, and Cardinals next. The Chicago Cubs are batting .254 on the season, have a .325 OBP, and a .444 slugging percentage. The Chicago Cubs pitching staff has a 3.83 ERA and a 1.26 WHIP. Kyle Tucker leads the Chicago Cubs with 81 hits and 46 RBI, while Nico Hoerner and Pete Crow-Armstrong have combined for 160 hits and 92 RBI. 

Ben Brown gets the ball for the Chicago Cubs, and he is 4-5 with a 5.57 ERA and 88 strikeouts this season. This will be Brown’s first career game against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 42-36 on the year and play the Guardians, Pirates, and Cubs next. The St. Louis Cardinals are batting .255 on the season, have a .327 OBP, and a .391 slugging percentage. The St. Louis Cardinals pitching staff has a 3.93 ERA and a 1.26 WHIP. Brendan Donovan leads the St. Louis Cardinals with 84 hits and 27 RBI while Alec Burleson and Nolan Arenado have combined for 137 hits and 69 RBI.

Matthew Liberatore gets the ball for the St. Louis Cardinals, and he is 4-6 with a 4.08 ERA and 66 strikeouts this season. Liberatore is 0-1 with a 4.38 ERA and 13 strikeouts in his career against the Chicago Cubs.

Why the St. Louis Cardinals will win

The Cardinals have won eight of their last nine home games against National League opponents following a loss.
The Cubs have lost each of their last six night games against the Cardinals at Busch Stadium following a loss.
The Cardinals have covered the run line in seven of their last eight night games against National League opponents that held a winning record.
The Cubs have failed to cover the run line in each of their last five games against National League opponents after playing the previous day.
The Cubs have trailed after 3 innings in each of their last three games against NL Central opponents that held a winning record.
The Cardinals have led after 5 innings in four of their last five games as favorites.

Why the Chicago Cubs will win

The Cubs have won each of their last five games as road underdogs against NL Central opponents.
The Cardinals have lost four of their last five games as favorites following a loss.
The Cubs have covered the run line in 14 of their last 15 games as road underdogs against NL Central opponents following a loss.
The Cardinals have failed to cover the run line in seven of their last eight night games against NL Central opponents following a home loss.

St. Louis Cardinals Player Prop Facts

Nolan Arenado has recorded a Double in three of his last four appearances in night games against NL Central teams that held a winning record.
Alec Burleson has hit a home run in two of the Cardinals’ last three games as favorites.
Willson Contreras has recorded at least one RBI in 16 of his last 20 home appearances against opponents that held a winning record.
Masyn Winn has scored a run in each of the Cardinals’ last five games as home favorites.
Masyn Winn has recorded at least one hit in each of the Cardinals’ last 10 games at Busch Stadium.
Brendan Donovan ranks 10th amongst qualified players for Batting Average (.308) this season.

Chicago Cubs Player Prop Facts

Ian Happ has hit at least one home run in three of the Cubs’ last four road games against NL opponents.
Seiya Suzuki has recorded a Double in each of the Cubs’ last three road games against NL Central opponents.
Nico Hoerner has scored a run in each of the Cubs’ last six games against NL Central opponents that held a winning record.
Dansby Swanson has recorded an RBI in four of the Cubs’ last five games against NL Central opponents.
Kyle Tucker has recorded at least one hit in each of his last nine road appearances against NL Central opponents that held a winning record.
Kyle Tucker ranks 5th amongst qualified players for On Base Percentage (.395) this season.

Chicago Cubs vs St. Louis Cardinals Prediction

The Cubs should be favored because they’re the better team, but I’m leaning toward the over in this spot. Brown has a 5.57 ERA and 1.48 WHIP on the season, and in 38.2 road innings, he has a 5.82 ERA and .280 allowed batting average. Liberatore has allowed 22 hits and 14 runs in his last 15 innings. Liberatore has allowed 29 hits and 18 earned runs in his last 20 innings. Both pitchers are in rough shape, and the Cubs can swing the bat and the Cards are coming off a strong offensive week. We should see some fireworks. Give me the over.

Randy Chambers's Pick: Over 9

Need More? Get Premium Picks

Hot Cappers this week

Latest Picks & Game Previews

  • Ana Bogdan vs Varvara Gracheva Prediction 07/14/2025 Iasi Picks

    July 14, 2025

  • Lois Boisson vs Julia Grabher Prediction 07/14/2025 Hamburg Picks

    July 14, 2025

  • Stan Wawrinka vs Alexander Shevchenko Prediction 07/14/2025 Gstaad Picks

    July 14, 2025