Chicago Cubs vs Kansas City Royals Prediction 07/22/2025 Picks

The Kansas City Royals are visiting the Chicago Cubs on Tuesday, July 22^nd at the Wrigley Field in the second game of this series, with the Royals having a 1-0 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Kansas City Royals vs Chicago Cubs Prediction. We will examine:

The Chicago Cubs’ recent form and player performance
The Kansas City Royals’ recent form and player performance
Recent betting trends and streaks involving the Chicago Cubs
Recent betting trends and streaks involving the Kansas City Royals
Recent betting trends in games played between the Kansas City Royals vs Chicago Cubs
A summary that ties it all together and produces a favorable betting outcome for the Kansas City Royals vs Chicago Cubs game

Chicago Cubs Preview

The Chicago Cubs have a 59-41 record this season and are sitting in second place in the NL Central. The Cubs have a 32-18 home record and are 49-42 in over/under. They are coming off a 4-12 home defeat by the Red Sox, and have back-to-back losses. Under is 4-2 in their last 6 games, and they are playing the White Sox and the Brewers next.

The Cubs have a .256 batting average this season, .324 OBP, and .447 Slugging percentage. Chicago’s pitching staff has a 3.87 ERA and 1.23 WHIP. Nico Hoerner leads the Cubs with 104 hits, while Michael Busch is the team’s best hitter with a .285 batting average. Seiya Suzuki leads the team in RBI, with 80, adding a team-high 26 home runs.

Matthew Boyd (R) is the projected starting pitcher for the Cubs, and he has a 10-3 record, 2.34 ERA, and 1.03 WHIP.

Kansas City Royals Preview

The Kansas City Royals have a 49-52 record this season and are sitting in third place in the AL Central. The Royals have a 25-26 road record and are 40-60 in over/under. They are coming off a 12-4 road victory over the Marlins and have back-to-back wins. Over is 3-1 in their last 4 games, and they are playing the Guardians and the Braves next.

The Royals have a .245 batting average this season, .300 OBP, and .379 Slugging percentage. Kansas’ pitching staff has a 3.49 ERA and 1.22 WHIP. Bobby Witt Jr. leads the Royals with 115 hits, while Maikel Garcia is the team’s best hitter with a .293 batting average. Salvador Perez leads the team in RBI, with 60, adding a team-high 17 home runs.

Reliever Rich Hill (L) is the projected starter for the Royals, and this will be his first start of the season. In four games played last season, he had a 4.91 ERA and 1.09 WHIP.  

Why the Chicago Cubs will win

The Cubs have won eight of their last nine home games against AL Central opponents following a loss.
The Royals have lost six of their last eight games at Wrigley Field against NL Central opponents that held a winning record.
The Cubs have covered the run line in seven of their last eight games as favorites against AL Central opponents following a loss.
The Royals have failed to cover the run line in four of their last five games against National League opponents following a win.
The Cubs have won the first inning in three of their last four games as home favorites.
The Royals have trailed after 5 innings in five of their last six games at Wrigley Field against National League opponents that held a winning record.
The Cubs have led after 3 innings in each of their last five home games.

Why the Kansas City Royals will win

The Royals have won each of their last seven night games against NL Central opponents.
The Cubs have lost three of their last four games as favorites against the Royals following a home loss.
The Royals have covered the run line in 15 of their last 16 road games against NL Central opponents.
The Cubs have failed to cover the run line in seven of their last eight night games against AL Central opponents.
The Royals have won the first inning in three of their last four road games against NL Central opponents.
The Royals have led after 5 innings in seven of their last eight games against NL Central opponents.
The Royals have led after 3 innings in three of their last four games against NL Central opponents.

Total Runs Facts

Each of the Royals’ last four road games against NL Central opponents have gone OVER the total runs line.
Five of the Cubs’ last six games as favorites against American League opponents have gone UNDER the total runs line.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Royals’ last five games as underdogs.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cubs’ last four games as home favorites against AL Central opponents.

Matchup/League Facts

The Cubs rank 1st in the league for RBIs this season (516).
The Cubs rank 2nd in the league for runs scored this season (527).
The Royals rank 30th in the league for walks this season (237).
The Royals rank 29th in the league for home runs this season (81).

Kansas City Royals vs Chicago Cubs Prediction

The Cubs are 4-2 in their last 6 meetings against the Royals, but the Royals are 5-2 in their last 7 visits to Chicago. Over is 3-0 in their last 3 meetings.    

In this Kansas City Royals vs Chicago Cubs Prediction, the Cubs are coming as -250 home favorites. The Cubs are rightfully favored, as they have a better overall record and have been one of the best home teams in the league. The Cubs are sending Boyd on the mound, who has been terrific this season and is coming in excellent form, with three shutouts in his last four starts. The Cubs also have a superior offense, and the Royals are going for a bullpen game, so this is the perfect bounce-back spot for the hosts. Take the Cubs to win comfortably and cover the runline.