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Cardinals vs Guardians Prediction 06/27/2025 Picks
Pick details
St. Louis (44-38) vs Cleveland (40-39)
June 27, 2025 at 07:10 PM EDT
The Line: Betting Odds: Cleveland +1.5 — Over/Under: +8.5
In this article we will formulate a Cardinals vs Guardians prediction for this MLB game on Friday, June 27th at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup
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St. Louis Cardinals Betting Preview
The St. Louis Cardinals are 44-38 this year after they split four games with the Cubs by scores of 8-2, 8-7, 0-8, and 0-3. In their game four loss, St. Louis fell behind in the second inning and they never got the offense going for the loss. The Cardinals recorded three hits in the game and they were led by Winn, Burleson, and Hampson, who all had one hit in the loss. St. Louis started Pallante, who allowed seven hits and two earned runs over 5.0 innings for the loss, while Romero allowed one earned run in relief.
Prior to that series, the Cardinals won two out of three against the Reds and all three against the White Sox. St. Louis has lost three of their last five games and they are currently third in the NL Central standings. The St. Louis pitching staff has a 3.98 ERA with a 1.27 WHIP and a .253 opponent batting average, while their offense has scored 382 runs with a .253 batting average and a .324 on base percentage this season. Wilson Contreras has led St. Louis with 10 home runs, 50 RBIs, and three stolen bases, while Nolan Arenado has added 10 home runs and 39 RBIs this year. The projected starting pitcher for St. Louis is Sonny Gray, who is 7-2 with a 3.72 ERA and a 1.19 WHIP over 84.2 innings pitched this year.
Cleveland Guardians Betting Preview
The Cleveland Guardians are 40-39 this season after they lost two out of three against Toronto by scores of 6-10, 5-4, and 0-6. In their game three loss, Cleveland allowed three runs in the third inning and one more in the ninth in the shutout loss. The Guardians recorded two hits and they committed four errors in the game, while they were led by Kwan and Manzardo, who both had one hit in the loss. Cleveland started Bibee, who allowed three hits and two earned runs over 6.0 innings for the loss, while Kent allowed two earned runs in relief.
Prior to that series, the Guardians won two out of three against the Athletics and two out of three against the Giants. Cleveland has won three of their last five games and they are currently second in the AL Central standings. The Cleveland pitching staff has a 3.90 ERA with a 1.37 WHIP and a .251 opponent batting average, while the offense has scored 297 runs with a .229 batting average and a .301 on base percentage this season. Jose Ramirez has led Cleveland with 13 home runs and 38 RBIs, while Kyle Manzardo has added 12 home runs and 32 RBIs this year. The projected starting pitcher for Cleveland is Luis Ortiz, who is 4-8 with a 4.30 ERA and a 1.41 WHIP over 81.2 innings pitched this season.
Why the Guardians will beat the Cardinals
The Cardinals have lost each of their last four games as favorites following a home loss.
The Guardians have won three of their last four games as underdogs against NL Central opponents following a home loss.
The Guardians have covered the run line in each of their last six games as home underdogs against NL Central opponents.
The Cardinals have failed to cover the run line in each of their last six games as road favorites following a home loss.
The Guardians have led after 5 innings in three of their last four games against National League opponents that held a winning record.
The Guardians have led after 3 innings in three of their last four games against National League opponents.
Why the Cardinals will beat the Guardians
The Guardians have lost six of their last seven games against NL Central opponents.
The Cardinals have won six of their last seven road games against AL Central opponents.
The Cardinals have covered the run line in seven of their last eight road games following a loss.
The Guardians have failed to cover the run line in each of their last three games.
The Cardinals have led after 5 innings in four of their last five games as favorites.
Total Runs Facts
Eleven of the Cardinals’ last 12 night games against American League opponents have gone OVER the total runs line.
Each of the Guardians’ last four games as underdogs against the Cardinals have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Cardinals’ last 10 games against American League opponents.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last five night games between the Cardinals and Guardians
Cleveland Guardians Player Prop Facts
Lane Thomas has hit a home run in three of the Guardians’ last four games at Progressive Field against opponents that held a winning record.
Nolan Jones has recorded a Double in four of his five previous appearances against the Cardinals.
Jose Ramirez has recorded at least one hit in each of the Guardians’ last 15 games at Progressive Field against NL opponents that held a winning record.
St. Louis Cardinals Player Prop Facts
Alec Burleson has hit a home run in three of the Cardinals’ last four games as road favorites against AL Central opponents.
Sonny Gray has recorded six or more strikeouts in each of his eight previous appearances with the Cardinals as favorites against AL opponents.
Willson Contreras has recorded at least one hit in each of his last 12 Friday night appearances with the Cardinals as favorites.
Sonny Gray has recorded a win in each of his last four appearances with his team as a road favorite against AL opponents.
Willson Contreras has recorded a Double in each of the Cardinals’ last three games against AL Central opponents that held a winning record.
Sonny Gray is one of only five pitchers to record 90+ Strikeouts and 20 or less Walks this season.
Matchup/League Facts
The Guardians rank 26th in the league for slugging percentage this season (.370).
The Guardians rank 25th in the league for runs scored this season (297).
The Cardinals rank T3rd in the league for walks allowed this season (222).
The Cardinals rank T3rd in the league for home runs allowed this season (70).
Cardinals vs Guardians Prediction
St. Louis comes into this matchup after getting shutout in back to back games, while Cleveland was also shutout in their game on Thursday. The Cardinals are 18-21 on the road this year, while the Guardians are 20-17 at home. Cleveland has allowed 20 runs in their last three games and they will start Ortiz, who has allowed 0, 6, and 4 earned runs in his last three outings. St. Louis is going with Gray, who has allowed one earned run or fewer in three of his last four. With both offenses struggling right now and Gray pitching pretty well, I like the under here.