Cardinals vs Cubs Prediction 07/05/2025 Picks

In this article we will formulate a Cardinals vs Cubs prediction for this MLB game on Saturday, July 5th at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

St. Louis Cardinals Betting Preview
The St. Louis Cardinals are 47-42 this season after they lost game one in this series by a score of 11-3 on Friday. St. Louis fell behind 7-0 in the third inning and they never had a chance in the blowout loss. The Cardinals recorded just three hits in the game and they were led by Pages, Nootbaar, and Donovan, who all had one RBI in the loss. St. Louis started Mikolas, who allowed 10 hits and eight earned runs over 6.0 innings for the loss, while King allowed three earned runs in relief. 

Prior to this series, the Cardinals lost all three against the Pirates, but did sweep the Guardians before that. St. Louis has lost four games in a row and they are currently third in the NL Central standings. The St. Louis pitching staff has a 4.02 ERA with a 1.26 WHIP and a .250 opponent batting average, while their offense has scored 406 runs with a .251 batting average and a .322 on base percentage this season. Wilson Contreras has led St. Louis with 11 home runs, 51 RBIs, and four stolen bases, while Nolan Arenado has added 10 home runs and 41 RBIs this year. The projected starting pitcher for St. Louis is Matthew Liberatore, who is 6-6 with a 3.70 ERA and a 1.16 WHIP over 92.1 innings pitched this season. 

Chicago Cubs Betting Preview
The Chicago Cubs are 53-35 this year after they won game one in blowout fashion on Friday afternoon. Chicago hit six home runs in the first three innings and they were able to cruise to the win. The Cubs recorded 13 hits and they committed one error in the game, while they were led by Busch, who went 4-4 with three home runs and five RBIs in the win. Chicago started Rea, who allowed one hit and one earned run over 6.2 innings for the win, while Berti allowed two earned runs in relief. 

Prior to this series, the Cubs swept the Guardians in three games, but lost two out of three against the Astros before that. Chicago has won four games in a row and they are currently first in the NL Central standings. The Chicago pitching staff has a 3.78 ERA with a 1.23 WHIP and a .245 opponent batting average, while their offense has scored 475 runs with a .256 batting average and a .326 on base percentage this season. Seiya Suzuki has led Chicago with 24 home runs and 74 RBIs, while Pete Crow-Armstrong has added 23 home runs and 66 RBIs this year. The projected starting pitcher for Chicago is Drew Pomeranz, who is 2-1 with a 0.00 ERA and a 0.90 WHIP over 23.1 innings pitched this year. 

Why the Cardinals will beat the Cubs
The Cubs have lost five of their last six games as home favorites against the Cardinals following a home win.
The Cardinals have won four of their last five games as road underdogs against the Cubs following a road loss.
The Cardinals have covered the run line in seven of their last eight games as road underdogs following a road loss.
The Cubs have failed to cover the run line in five of their last six games as favorites against the Cardinals following a home win.

Total Runs Facts
Each of the Cardinals’ last four games after playing the previous day have gone UNDER the total runs line.
Four of the Cubs’ last five day games as favorites have gone OVER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in 13 of the Cubs’ last 16 day games at Wrigley Field.
The ‘Inning 1 OVER 0.5 runs’ market has hit in three of the Cardinals’ last four games as underdogs.

Chicago Cubs Player Prop Facts
Dansby Swanson has recorded at least one hit in each of the Cubs’ last seven games as favorites.
Dansby Swanson has hit a home run in each of the Cubs’ last two games as home favorites against NL Central opponents.

St. Louis Cardinals Player Prop Facts
Lars Nootbaar has recorded a hit in each of his last six appearances in day games.
Lars Nootbaar has hit a home run in two of his last three appearances against NL opponents that held a winning record.

Cardinals vs Cubs Prediction 
St. Louis was able to finally score a run in their loss on Friday afternoon, but they have dropped four games in a row and have been out scored 24-3 in that span. The Cardinals are 21-25 on the road this year, while the Cubs are 29-15 at home. Chicago is looking for their fifth straight win and they will start Pomeranz, who will serve as an opener. The Cardinals are going with Liberatore, who has allowed two earned runs or fewer in three straight outings. I really don’t like how St. Louis is playing, but I think Liberatore gives them a chance to win, so give me the Cardinals and the plus money.