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Boston Red Sox vs San Francisco Giants Prediction 06/21/2025 Picks
Pick details
Boston (40-37) vs San Francisco (42-34)
June 21, 2025 at 04:05 PM EDT
The Line: Betting Odds: San Francisco -1.5 — Over/Under: +8
In this article, we will formulate a Red Sox vs Giants prediction for this MLB game on Saturday, June 21, at Oracle Park in San Francisco, California. Let’s take a look at the prediction for this MLB matchup.
Boston Red Sox Betting Preview
The Boston Red Sox (40-37, 18-20 Away) are going through their best period of the season; they won ten of the previous 12 games. Boston defeated the Yankees and Rays, swept the Yankees, and then beat the Mariners on the road. The Red Sox opened the current series against the San Francisco Giants with a 7-5 victory on Friday. Ceddanne Rafaela and David Hamilton led the offense with two RBI apiece, while Hunter Dobbins pitched for 4.0 innings in a no-decision, allowing five runs (four earned) with one strikeout and five walks. Brennan Bernandino was credited with the win.
This year, the Red Sox average 4.74 runs per game (6th in the MLB) on a .249/.323/.417 triple-slash. When it comes to pitching, the Red Sox’s staff has a 3.93 ERA (18th) and 1.31 WHIP (21st). Trevor Story leads the Red Sox with a .227 batting average, ten home runs, and 38 RBI this season.
The projected starting pitcher for the Red Sox is Brayan Bello, who is 3-1 in 11 starts this season, with a 3.49 ERA and 1.47 WHIP in 59.1 innings.
San Francisco Giants Betting Preview
The San Francisco Giants (42-34, 23-14 Home) snapped a four-game losing skid with a win over the Cleveland Guardians, avoiding getting swept along the way, but returned to losing ways with a 7-5 defeat to the Boston Red Sox in Game 1 of the current series. Hayden Birdson pitched for 4.1 innings in a no-decision, allowing five runs (four earned) with four strikeouts and one walk. Sean Hjelle took the loss.
This season, the Giants average 4.21 runs per game (19th in the MLB) on a .232/.313/.372 triple-slash. When it comes to pitching, the Giants’ staff has a 3.27 ERA (3rd) and 1.21 WHIP (8th). Wilmer Flores leads the Giants with a .255 batting average, 11 home runs, and 54 RBI this season.
Landen Roupp will take the mound for the Giants on Saturday. The 26-year-old right-hander has a 4-5 record in 14 starts this year with a 3.99 ERA and 1.46 WHIP in 70.1 innings.
Total Runs Facts
Twelve of the Giants’ last 13 games against AL East opponents have gone OVER the total runs line.
Five of the Red Sox’s last six road games against NL West opponents have gone OVER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Giants’ last eight games as favorites against AL East opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Red Sox’s last four road games against National League opponents.
Matchup/League Facts
The Giants rank 3rd in the league for ERA this season (3.27).
The Giants rank 27th in the league for slugging percentage this season (.372).
The Red Sox are one of only four teams in the league to rank top 10 in both steals and home runs this season.
The Red Sox rank 5th in the league for hits this season (662).
Red Sox vs Giants Prediction
The teams have traded wins in the past couple of years, each recording five in the previous ten H2H duels. Even though the Red Sox’s defense improved lately, they did allow five runs last night, and I am backing the Giants to score 3+ in this one. Brayan Bello was excellent in his latest start against the struggling Yankees, but he surrendered multiple runs in five of his previous seven starts. Landen Roupp, on the other hand, was excellent in May ( a 1.73 ERA), but allowed nine runs in his last two starts against the Braves and Dodgers. I am backing both offenses to score 3+ runs off starters here. Go with Over.