Sep 1, 2025; Cincinnati, Ohio, USA; Cincinnati Reds outfielder TJ Friedl (29) hits a RBI ground-rule double in the ninth inning against the Toronto Blue Jays at Great American Ball Park. Mandatory Credit: Katie Stratman-Imagn Images

Blue Jays vs Reds Prediction 9/2/2025 Today’s MLB Picks

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Toronto (79-59) vs Cincinnati (70-68)

September 2, 2025 at 06:40 PM EDT

The Line: Betting Odds: Cincinnati -125 — Over/Under: +8.5

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In this article we will formulate a Blue Jays vs Reds prediction for this MLB game on Tuesday, September 2nd at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Toronto Blue Jays Betting Preview

The Toronto Blue Jays are 79-59 this year after they lost game one in this series by a score of 5-4 on Monday afternoon. Toronto led 4-2 in the ninth inning, but they allowed three runs in the bottom of the ninth for the loss. The Blue Jays recorded eight hits and they committed one error in the game, while they were led by Bichette, who went 4-4 with one home run and two RBIs in the loss. Toronto started Bassitt, who allowed five hits and two earned runs over 6.0 innings, while Little blew the save and picked up the loss. 

Prior to this series, the Blue Jays lost two out of three against the Brewers, but did win two out of three against the Twins before that. Toronto has lost three of their last four games and they are currently first in the AL East standings. The Toronto pitching staff has a 4.25 ERA with a 1.27 WHIP and a .241 opponent batting average, while their offense has scored 679 runs with a .268 batting average and a .337 on base percentage this season. Vladimir Guerrero Jr. has led Toronto with 21 home runs and 74 RBIs, while George Springer has added 24 home runs and 68 RBIs this year. The projected starting pitcher for Toronto is Jose Berrios, who is 9-5 with a 3.95 ERA and a 1.26 WHIP over 152.2 innings pitched this year. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 70-68 this season after they won game one by a score of 5-4 on Monday afternoon. Cincinnati led 2-0 in the second inning, but they didn’t score again until the ninth, when they completed the comeback for the win. The Reds recorded 11 hits in the game and they were led by Hayes and Marte, who both had two RBIs in the win. Cincinnati started Greene, who allowed five hits and one earned run over 6.1 innings, while Zulueta picked up the win in relief. 

Prior to this series, the Reds lost two out of three against the Cardinals and all three against the Dodgers. Cincinnati has lost five of their last seven games and they are currently third in the NL Central standings. The Cincinnati pitching staff has a 3.85 ERA with a 1.24 WHIP and a .235 opponent batting average, while their offense has scored 616 runs with a .247 batting average and a .317 on base percentage this season. Elly De La Cruz has led Cincinnati with 19 home runs and 77 RBIs, while Spencer Steer has added 17 home runs and 63 RBIs this year. The projected starting pitcher for Cincinnati is Nick Lodolo, who is 8-7 with a 3.22 ERA and a 1.04 WHIP over 134.1 innings pitched this season. 

Why the Blue Jays will beat the Reds

The Blue Jays have won each of their last 12 Tuesday night games against NL Central opponents.
The Reds have lost seven of their last eight Tuesday games as home favorites against American League opponents.
The Blue Jays have covered the run line in each of their last 10 Tuesday night games against NL Central opponents.
The Reds have failed to cover the run line in each of their last eight Tuesday night games as home favorites against American League opponents.

Total Runs Facts

Seven of the Blue Jays’ last eight games after playing the previous day have gone OVER the total runs line.
Five of the Reds’ last six games as favorites have gone OVER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Blue Jays’ last eight Tuesday night games against National League opponents.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Reds’ last six home games against American League opponents.

Cincinnati Reds Player Prop Facts

Will Benson has hit at least one home run in three of his last seven appearances at Great American Ball Park against AL opponents that held a winning record.
Elly De La Cruz has recorded at least one hit in each of the Reds’ last nine home games.
Nick Lodolo has recorded four or more strikeouts in each of his last 10 appearances at Great American Ball Park.

Toronto Blue Jays Player Prop Facts

Bo Bichette has recorded at least one Double in four of the Blue Jays’ last five road games against NL opponents.
Daulton Varsho has hit a home run in three of the Blue Jays’ last four road games against NL opponents.
George Springer has recorded at least one hit in each of the Blue Jays’ last 10 road games against NL Central opponents.
Jose Berrios has recorded five or more strikeouts in four of his last five road appearances against NL opponents.
Jose Berrios has recorded a win in five of his last six appearances in night games.

Blue Jays vs Reds Prediction 

Cincinnati was able to get the dramatic win on Monday afternoon with a few runs in the bottom of the ninth, and they will look to make it three wins in a row here. The Reds are 38-31 at home this season, while the Blue Jays are 34-35 on the road. Toronto has dropped three of their last four games and they are starting Berrios, who has allowed 2, 6, 0, 3, and 2 earned runs in his last five outings. Cincinnati is going with Lodolo, who allowed four earned runs in his first start off of the IL. Take the Blue Jays on the road here.

David Racey's Pick: Blue Jays ML

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