Charleston Southern vs Clemson Prediction 10/17/2026 Today’s College Football Picks

The Charleston Southern Buccaneers and the Clemson Tigers meet in week 7 college football action from Memorial Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Charleston Southern Buccaneers vs. Clemson Tigers Prediction.

Charleston Southern Buccaneers Recap

The Charleston Southern Buccaneers come into this game looking to build on a 49-39 win over South Carolina State last time out to sit at 3-3 this season. After this game, Charleston Southern will head on the road for a matchup against Tennessee State.

Buccaneers Looking For Massive Upset

Lek Powell has thrown for 552 yards while Hakeem Watters leads Charleston Southern in rushing with 369 yards. Mekhi Campfield leads the Buccaneers in receiving with 198 yards. On defense, Steve Zayachkowsky has a team-high 60 tackles while Kason Hooks leads the team with 2 interceptions.

Clemson Tigers Recap

The Clemson Tigers come into this game looking to bounce back from their 41-13 loss at the hands of Miami last time out to sit at 3-2 this season. After this game, Clemson will take on Virginia Tech in a matchup at home.

Tigers Have Three-Game Win Streak Snapped

Tait Reynolds has thrown for 816 yards, a touchdown and 3 interceptions on 64.8% passing while Gideon Davidson leads Clemson in rushing with 371 yards and 4 touchdowns. Chris Johnson Jr. sits behind Davidson on the ground with 101 yards. Bryant Wesco Jr. leads the Tigers in receiving with 315 yards and 25 catches, while T.J. Moore trails with 235 yards and 25 catches along with a touchdown. On defense, Corey Myrick has a team-high 43 tackles while Clemson’s defense as a whole has combined for 10 sacks and 4 interceptions.

Charleston Southern Buccaneers @ Clemson Tigers Betting Trends: Week 7

Why the Clemson Tigers will win

• Clemson has won 23 of its last 25 home games in October.
• Clemson has won the first quarter in 14 of its last 15 games against non-FBS teams.
• Clemson has won the first half in each of its last 15 games against non-FBS teams.

Why the Charleston Southern Buccaneers will win

• Clemson has failed to cover the spread in each of its last 11 home games against teams from South Carolina.
• The road team has won the first half in each of Clemson’s last three games.

Total Points Facts

• Four of Clemson’s last five games against non-conference opponents at Memorial Stadium (Clemson) have gone UNDER the total points line.

Clemson Tigers Player Prop Facts

• Heading into Week 7, Nolan Hauser ranks T3rd amongst FBS players for made field goals (12) this season.

Matchup/League Facts

• Clemson ranks 134th among FBS teams for average point differential in first quarters this season (-6.4).
• Clemson ranks T131st among FBS teams for Q1 opponent points per game this season (9.6).

Charleston Southern Buccaneers vs. Clemson Tigers Prediction

I’m on the over here. I don’t think Charleston Southern’s going to be able to stop Clemson, even as poor as Clemson has been this season. However, a lot of times, Clemson’s issues have been in step up spots and they’ve been able to knock off inferior competition. Charleston Southern can still contribute some here, and I think rather than lay a massive number with Clemson, I’d rather just bank on points and take the over.

Chris Ruffolo's Pick: Over 58.5