Baltimore Orioles vs St. Louis Cardinals Prediction 8/26/2026 Today’s MLB Picks

The Baltimore Orioles and the St. Louis Cardinals meet Wednesday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Baltimore Orioles vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Baltimore Orioles will send out Kyle Bradish for the start here and Bradish is 7-12 with a 3.70 ERA and 129 strikeouts this season. Michael McGreevy will start for St. Louis and is 5-9 with a 3.54 ERA and 95 strikeouts this season.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to add on to their 13-1 win over the Cardinals to sit at 64-68 this season. After this series, the Orioles will take on the Athletics in a series on the road.

Orioles Win 3 Of Last 4

Gunnar Henderson has 115 hits with 23 doubles, 20 home runs and 51 RBIs and Pete Alonso has 137 hits with 24 doubles, 31 home runs and 89 RBIs. Jeremiah Jackson has 53 hits with 10 doubles, 7 home runs and 39 RBIs as well on the year. Samuel Basallo has 70 hits with 9 doubles, 17 home runs and 48 RBIs.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to rebound from their loss at the hands of Baltimore last time out to sit at 66-67 this season. After this series, the Cardinals will take on the Pittsburgh Pirates in a series at home.

Cardinals Lose 4 In A Row

Jordan Walker has 144 hits, 28 doubles, 27 home runs and 96 RBIs while Alec Burleson has 146 hits with 33 doubles, 21 home runs and 96 RBIs. JJ Wetherholt has 121 hits with 17 home runs and 48 RBIs while Ivan Herrera has 120 hits with 23 doubles, 14 home runs and 53 RBIs. Masyn Winn’s added 103 hits with 19 doubles and 51 RBIs and Nathan Church has 77 hits with 9 home runs and 41 RBIs this season. 

Baltimore Orioles @ St. Louis Cardinals Betting Trends: August 26, 2026

• Probable Starting Pitcher: Michael McGreevy      Record this season: 5-9      ERA: 3.54
• Home Record: 2-4
• Last 5 against Orioles: –

Why the St. Louis Cardinals will win

• The Orioles have lost eight of their last nine games as favorites against NL opponents following a road win.
• The Cardinals have won each of their last five games as underdogs against the Orioles.
• The Orioles have failed to cover the run line in each of their last seven games as favorites against NL Central opponents following a road win.
• The underdogs have covered the run line in nine of the Cardinals’ last 10 games at Busch Stadium.
• The Cardinals have led after 5 innings in six of their last seven games against opponents that held a losing record.
• The Orioles have trailed after 3 innings in four of their last five night games.

• Probable Starting Pitcher: Kyle Bradish      Record this season: 7-12      ERA: 3.70
• Road Record: 4-6
• Last 5 against Cardinals: 1-0

Why the Baltimore Orioles will win

• The Cardinals have lost each of their last eight games against AL East opponents following a home loss.
• The Orioles have won each of their last four night games against NL Central opponents that held a losing record.
• The Cardinals have failed to cover the run line each of their last six night games against AL opponents that held a losing record.
• The Orioles have covered the run line in seven of their last eight road games against NL opponents.
• The Orioles have led after 5 innings in each of their last four road games.
• The Orioles have led after 3 innings in four of their last five games against the Cardinals.

Total Runs Facts

• Each of the Cardinals’ last six games have gone OVER the total runs line.
• Each of the Orioles’ last six games as road favorites have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of Michael McGreevy’s last nine appearances as a starter.
• There has been no run scored during the first inning in each of the Orioles’ last eight Wednesday games against NL Central opponents.

St. Louis Cardinals Player Prop Facts

• Jordan Walker has hit a home run in three of the Cardinals’ last four games as home underdogs against AL East opponents.
• Michael McGreevy has recorded five or more strikeouts in each of his last four appearances with the Cardinals as underdogs.
• Alec Burleson has recorded at least one hit in each of the Cardinals’ last 11 games.
• Alec Burleson ranks 6th in the league in Hits (146) this season.

Baltimore Orioles Player Prop Facts

• Christian Encarnacion-Strand has hit a home run in three of the Orioles’ last four road games.
• Kyle Bradish has recorded five or more strikeouts in each of his 19 previous appearances with the Orioles as road favorites.
• Samuel Basallo has recorded at least one hit in each of the Orioles’ last seven night games against NL opponents that held a losing record.
• Pete Alonso ranks 8th in the league in Home Runs (31) this season.

Matchup/League Facts

• The Cardinals rank 27th in the league for doubles this season (187).
• The Cardinals rank 4th in the league for home runs allowed this season (131).
• The Orioles rank 3rd in the league for walks this season (493).
• The Orioles rank 27th in the league for hits this season (1036).

Baltimore Orioles vs. St. Louis Cardinals Prediction

I’m backing Baltimore in this one. I get the case to be made for St. Louis but I think we’re starting to see St. Louis regress and run out of gas, and I think Baltimore builds on their strong start to the series with a win here. I’ll take Baltimore.

Chris Ruffolo's Pick: Baltimore -115