Baltimore Orioles vs New York Yankees Prediction 9/27/2025 Today’s MLB Picks

The Baltimore Orioles and New York Yankees meet on Saturday in MLB action from Yankee Stadium. Here’s a Baltimore Orioles vs New York Yankees prediction. We will look at this from a betting perspective and determine the best Orioles vs Yankees pick. We will examine:

The Baltimore Orioles’ recent form and player performance

The New York Yankees’ recent form and player performance

Recent betting trends and streaks involving the Yankees

Recent betting trends and streaks involving the White Sox

Recent betting trends in games played between the Yankees and White Sox

A summary that ties it all together and produces a favorable betting outcome for the White Sox and Yankees game.

Another Loss for the Orioles

It was another loss for the Orioles on Friday and they ended up losing 8-4. At one point the Orioles were up 3-2 but it quickly all fell apart because of the pitching. Trevor Rogers was good most of the season, but he was awful on Friday, going three innings giving up three hits and six runs. Yennier Cano went one inning and also had his issues giving up four hits and two runs. If the pitching struggles again in this game, it’s going to be an awful game. 

The Orioles are averaging 4.21 runs while their pitching is giving up 4.85 runs per game. The offense is ranked 23rd in the league while the pitching is ranked 25th. A negative run differential of over -0.6 just isn’t even close to good enough to be competitive. They are averaging 7.92 hits per game and they really need to start turning those into more runs. Tomoyuki Sugano is on the mound for the Orioles and he sits with a 10-9 record and an ERA of 4.54. In his last start against the Yankees he went three innings giving up six hits and four runs. The Orioles have lost each of his last five starts. 

Why the Baltimore Orioles will win

• The Orioles have won six of their last eight games as road underdogs against the Yankees following a loss.
• The Yankees have lost eight of their last 12 games as favorites against the Orioles following a win.
• The Orioles have covered the run line in 15 of their last 17 games as underdogs against AL East opponents following a road loss.
• The Yankees have failed to cover the run line in 19 of their last 24 home games against AL East opponents following a win.

Yankees Need This Win

The Yankees are trying to lock up the American League East still, but they don’t have the tiebreaker against the Toronto Blue Jays, so it probably is going to take them winning out to have a chance. On Friday the Yankees were able to put up eight runs, and that was enough to pick up the victory. Giancarlo Stanton couldn’t be slowed down, and he ended up hitting two home runs and driving in five RBIs. 

The Yankees are averaging 5.23 runs while their pitching is giving up 4.26 runs per game. The offense is ranked 1st in the league while the pitching is ranked 14th. They have a positive run differential of 0.97 which is 2nd in all of baseball. Cam Schlittler sits with the Yankees and he sits with a 3-3 record and an ERA of 3.27. Against the Orioles in his last start he went 5.1 innings giving up three hits and one run. The Yankees need to have another strong start from him to get the job done here. 

Why the New York Yankees will win

• The Yankees have won each of their last seven games at Yankee Stadium against teams that held a losing record.
• The Orioles have lost 11 of their last 12 games against AL East opponents that held a winning record.
• The Yankees have covered the run line in seven of their last eight games after playing the previous day.
• The Orioles have failed to cover the run line in five of their last six games against AL East opponents that held a winning record.
• The Orioles have trailed after 5 innings in four of their last five games at Yankee Stadium against opponents that held a winning record.
• The Orioles have lost the first inning in three of their last four road games against American League opponents.
• The Orioles have trailed after 3 innings in four of their last five games at Yankee Stadium against opponents that held a winning record.

Baltimore Orioles vs New York Yankees Prediction 

Not only are the Yankees the better team, they have a big advantage on the mound here. Sugano is on the mound and in his last start he gave up six hits and four runs. The Orioles haven’t been giving him any support, and it’s not going to be any different here. Schlitter was strong in his last start against the Orioles, and the Yankees aren’t going to give up more than three total runs here. This game will be over early. Back the Yankees to win this game on the run line.