Baltimore Orioles vs Arizona Diamondbacks Prediction 4/7/25 MLB Picks

In this article, we will formulate an Orioles vs Diamondbacks prediction for this MLB game on Monday, April 7, at Chase Field in Phoenix, Arizona. Let’s take a look at the prediction for this MLB matchup.

Baltimore Orioles Betting Preview

The Baltimore Orioles (4-6, 3-4 Away) split a four-game series with the Blue Jays to open the season and then lost the following two series to the Red Sox and Royals, winning one game in each of the series. In the latest 4-1 defeat to Kansas City, Baltimore had only five hits as opposed to the Royals’ 13. Cade Povich took a loss after allowing four runs on 13 hits with four strikeouts and no walks in 6.0 innings.

This year, the Orioles average 4.70 runs per game (11th in the MLB) on a .263/.324/.419 triple-slash. When it comes to pitching, the Orioles’ staff has a 4.71 ERA (22nd) and 1.40 WHIP (24th). Cedric Mullins leads the Orioles with a .313 batting average, three home runs, and 11 RBI this season.

Zach Eflin will take the mound for the Diamondbacks on Monday. The 30-year-old right-hander has a 1-1 record in two starts this year with a 3.75 ERA and 0.92 WHIP over 12.0 innings of work.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks (5-5, 2-2 Home) also split the opening series of the season with the Chicago Cubs and then beat the Yankees and unexpectedly lost to the Nationals. In the most recent 5-4 defeat to Washington, Corbin Burnes took a loss after allowing four runs on seven hits with three strikeouts and four walks.

This season, the Diamondbacks average 5.80 runs per game (5th in the MLB) on a .261/.350/.450 slash line. Regarding pitching, the Diamondbacks’ staff has a 5.07 ERA (26th) and 1.24 WHIP (12th). Geraldo Perdomo leads the Diamondbacks with a .314 batting average, one home run, and 12 RBI this season.

The projected starting pitcher for the Diamondbacks is Zac Gallen, who has a 1-1 record in two starts this year with a 3.38 ERA and 1.03 WHIP in 10.2 innings.

Why the Diamondbacks will beat the Orioles

• The Diamondbacks have won six of their last seven home games against American League opponents that held a losing record.
• The Orioles have lost five of their last six night games against NL West opponents.
• The Diamondbacks have covered the run line in six of their last seven games against the Orioles following a loss.
• The Orioles have failed to cover the run line in five of their last six night games against National League opponents.
• The Orioles have lost the first inning in three of their last four road games.
• The Diamondbacks have led after 3 innings in six of their last seven games against American League opponents.
• The Orioles have trailed after 5 innings in four of their last five games as underdogs against National League opponents.

Total Runs Facts

• Each of the Diamondbacks’ last four home games against AL East opponents have gone OVER the total runs line.
• Five of the Orioles’ last six night games against NL West opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Diamondbacks’ last six home games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Orioles’ last five road games.

Orioles vs Diamondbacks Prediction

The Orioles won six of the previous ten H2H encounters, including four of the last five. Zach Eflin doesn’t have such great numbers against the Diamondbacks in his career; he allowed a .312 BA with four home runs and 13 RBI in 80 at-bats. Zac Gallen allowed a .158 BA with two RBI in 64 at-bats against the Orioles, so I am giving an advantage to the home team starter and the D-backs. Back Arizona to get a win.