Athletics vs Red Sox Prediction 9/17/2025 Today’s MLB Picks

In this article we will formulate an Athletics vs Red Sox prediction for this MLB game on Wednesday, September 17th at Fenway Park in Boston, Massachusetts. Let’s take a look at the prediction for this MLB matchup. 

Athletics Betting Preview

The Athletics are 71-80 this season after they won game one by a score of 2-1 on Tuesday night. The Athletics trailed 1-0 early in the game, but they scored twice in the sixth to get the victory. The A’s recorded nine hits and they committed one error in the game, while they were led by Soderstrom and Harris, who both had one RBI in the win. The Athletics started Springs, who allowed five hits and zero earned runs over 4.0 innings, while Spence got the win and Harris got the save. 

Prior to this series, the Athletics won all three against the Reds, but lost two out of three against the Red Sox before that. The Athletics have won five games in a row and they are fourth in the AL West standings. The Athletics pitching staff has a 4.74 ERA with a 1.36 WHIP and a .252 opponent batting average, while the offense has scored 696 runs with a .255 batting average and a .321 on base percentage this season. Brent Rooker has led the Athletics with 26 home runs and 85 RBIs, while Nick Kurtz has added 32 home runs and 80 RBIs this year. The projected starting pitcher for the Athletics is Mason Barnett, who is 1-1 with an 8.53 ERA and a 1.89 WHIP over 12.2 innings pitched this season. 

Boston Red Sox Betting Preview

The Boston Red Sox are 82-69 this year after they lost game one by a score of 2-1 last night. Boston led 1-0 in the third inning, but they went scoreless over the last six innings for the loss. The Red Sox recorded eight hits in the game and they were led by Story, who went 3-4 in the loss. Boston started Early, who allowed five hits and one earned run over 5.1 innings, while Weissert picked up the loss. 

Prior to this series, the Red Sox lost two out of three against the Yankees, but did win two out of three against the Athletics before that. Boston has lost four of their last five games and they are third in the AL East standings. The Boston pitching staff has a 3.73 ERA with a 1.29 WHIP and a .245 opponent batting average, while their offense has scored 737 runs with a .254 batting average and a .324 on base percentage this season. Wilyer Abreu (IL) has led Boston with 22 home runs and 69 RBIs, while Trevor Story has added 24 home runs and 91 RBIs this year. The projected starting pitcher for Boston is Lucas Giolito, who is 10-4 with a 3.31 ERA and a 1.25 WHIP over 136.0 innings pitched this year. 

Why the Red Sox will beat the Athletics 

The Red Sox have won 10 of their last 12 home games against the Athletics following a home loss.
The Athletics have lost 16 of their last 20 night games against AL East opponents following a win.
The Red Sox have covered the run line in eight of their last 10 home games against the Athletics following a home loss.
The Athletics have failed to cover the run line in six of their last eight games against the Red Sox following a road win.
The Athletics have trailed after 3 innings in each of their last four night games against AL East opponents.
The Athletics have trailed after 5 innings in each of their last four night games against AL East opponents.

Total Runs Facts

Seven of the last eight games between the Athletics and Red Sox have gone UNDER the total runs line.
Each of the Athletics’ last five games against American League opponents have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Red Sox’s last six Wednesday night games against American League opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Athletics’ last six games as underdogs against American League opponents.

Boston Red Sox Player Prop Facts

Trevor Story has recorded at least one hit in each of the Red Sox’s last six games as favorites.
Lucas Giolito has recorded a win in each of his last three appearances with the Red Sox as favorites against AL opponents.
Triston Casas has hit a home run in three of his last four appearances with the Red Sox as home favorites against AL West opponents.
Lucas Giolito has recorded six or more strikeouts in six of his last seven appearances in night games against AL West teams that held a losing record.
Jarren Duran has recorded a Double in three of the Red Sox’s last four games against the Athletics.

Athletics Player Prop Facts

JJ Bleday has recorded at least one hit in each of his last eight Wednesday appearances against AL East teams that held a winning record.
Nick Kurtz has hit a home run in three of the Athletics’ last four games as underdogs.

Athletics vs Red Sox Prediction 

Boston continued their rough stretch with a loss on Tuesday to start this series and they are now seven games back in the AL East. The Red Sox are 45-31 at home this year, while the Athletics are 38-38 on the road. The A’s have won five games in a row and they are starting Barnett, who has allowed 3, 4, and 5 earned runs in his first three outings. Boston is going with Giolito, who has allowed two earned runs or fewer in four straight starts. Take the Sox -1.5 here.