Athletics vs Houston Astros Prediction 5/28/25 MLB Picks

The Athletics and Houston Astros meet Wednesday in MLB action at Daikin Park. Here’s an Athletics vs Houston Astros Prediction. This article will include an Athletics vs Houston Astros Pick.

Athletics Betting Preview

The Athletics are 23-32 on the year and play the Blue Jays, Twins, and Orioles next. The Athletics are batting .256 on the season, have a .320 OBP, and a .417 slugging percentage. The Athletics’ pitching staff has a 5.40 ERA and a 1.49 WHIP. Jacob Wilson leads the Athletics with 71 hits and 28 RBI, while Tyler Soderstrom and Brent Rooker have combined for 111 hits and 57 RBI. 

Luis Severino gets the ball for the Athletics, and he is 1-4 with a 4.11 ERA and 50 strikeouts this season. Severino is 2-4 with a 4.96 ERA and 54 strikeouts in his career against the Houston Astros.

Houston Astros Betting Preview

The Houston Astros are 29-25 on the year and play the Rays, Pirates, and Guardians next. The Houston Astros are batting .256 on the season, have a .324 OBP, and a .394 slugging percentage. The Houston Astros’ pitching staff has a 3.38 ERA and a 1.15 WHIP. Jeremy Pena leads the Houston Astros with 61 hits and 27 RBI, while Jose Altuve and Isaac Paredes have combined for 110 hits and 52 RBI.

Lance McCullers Jr. gets the ball for the Houston Astros, and he is 0-1 with a 6.57 ERA and 14 strikeouts this season. McCullers is 7-3 with a 3.23 ERA and 86 strikeouts in his career against the Athletics.

Why the Houston Astros will win

• The Athletics have lost 12 of their last 13 games.
• The Astros have won eight of their last nine games against the Athletics at Daikin Park following a win.
• The Athletics have failed to cover the run line in seven of their last eight games against American League opponents.
• The Astros have covered the run line in five of their last six home games against American League opponents that held a losing record.
• The Athletics have trailed after 5 innings in five of their last six games against American League opponents.
• The Athletics have trailed after 3 innings in four of their last five road games.

Why the Athletics will win

• The underdogs have won four of the Astros’ last five games at Daikin Park.
• The Astros have lost nine of their last 10 day games following a win.
• The Astros have failed to cover the run line in nine of their last 10 day games following a win.
• The Athletics have covered the run line in eight of their last nine road games against American League opponents after playing the previous day.
• The Astros have trailed after 5 innings in three of their last four day games against American League opponents.

Houston Astros Player Prop Facts

• Isaac Paredes has hit a home run in five of the Astros’ last six games as favorites against AL West opponents.
• Isaac Paredes has recorded a Double in three of the Astros’ last four games at Daikin Park against opponents that held a losing record.
• Lance McCullers Jr. has recorded a win in six of his last eight appearances with the Astros as home favorites against AL opponents.
• Yainer Diaz has scored at least one run in each of the Astros’ last six games at Daikin Park against AL West opponents that held a losing record.
• Lance McCullers Jr. has recorded five or more strikeouts in 17 of his last 18 home appearances against AL West opponents.
• Jeremy Pena has recorded at least one Single in 12 of the Astros’ last 13 games as home favorites.
• Mauricio Dubon has recorded at least one hit in each of his last 12 appearances at Daikin Park.
• Yordan Alvarez has recorded an RBI in each of his last four appearances with the Astros as home favorites against AL opponents.

Athletics Player Prop Facts

• Lawrence Butler has hit a home run in each of his last two appearances with the Athletics against AL opponents.
• Lawrence Butler has recorded an RBI in four of his last five appearances with the Athletics as underdogs against AL opponents.
• Lawrence Butler has scored a run in each of his last five appearances against AL West opponents.
• Luis Severino has recorded five or more strikeouts in seven of his last nine appearances in day games.
• Miguel Andujar has recorded at least one hit in each of his last 11 appearances after playing the previous day.
• Gio Urshela has recorded at least one Single in each of his last 10 appearances at Daikin Park against AL West opponents that held a winning record.
• JJ Bleday has recorded a Double in three of his last four appearances with the Athletics as underdogs against AL West opponents.
• Jacob Wilson ranks 3rd amongst qualified players for Batting Average (.348) this season.

Athletics vs Houston Astros Prediction

The Athletics have won one game since May 14, so they’re not a team I’m trying to back. Severino has also been shaky lately, allowing 25 hits and 14 runs in his last 22 innings. Severino has been fantastic on the road this season, but it’s hard to back a team that’s won one game in the last two weeks. The Astros are starting to pile up the wins, and while McCullers has been a mess through 12.1 innings, we know what he’s capable of when he’s right. The more reps McCullers gets under his belt, the sharper he’s going to be. McCullers has allowed just two earned runs in his last 8.1 innings. Give me the Astros and the reasonable price.