Astros vs Orioles Prediction 4/29/2026 Today’s MLB Picks

In this article we will formulate an Astros vs Orioles prediction for this MLB game on Wednesday, April 29th at Camden Yards in Baltimore, Maryland. Let’s take a look at the prediction for this MLB matchup. 

Houston Astros Betting Preview

The Houston Astros are 11-19 this year after they lost game one by a score of 5-3 on Tuesday night. Houston cut the deficit to 5-3 in the eighth inning, but couldn’t get any closer in the loss. The Astros recorded 11 hits in the game and they were led by Matthews, who went 3-4 with one home run and two RBIs. Teng allowed five hits and two earned runs over 3.0 innings for the loss, while Weiss allowed three earned runs in relief. Prior to this series, Houston lost two out of three against the Yankees, but did win two out of three against the Guardians before that. 

This season, Houston has a 5.96 ERA with a 1.64 WHIP and a .268 opponent batting average, while they have scored 154 runs with a .260 batting average and a .344 on base percentage. Yordan Alvarez has led the Astros with 11 home runs and 26 RBIs, while Christian Walker has added seven home runs and 23 RBIs. The projected starting pitcher for Houston is Peter Lambert, who is 1-1 with a 3.27 ERA and a 1.27 WHIP over 11.0 innings pitched this year. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 14-15 this season after they won game one by a score of 5-3 last night. Baltimore scored two runs in the first inning and they never looked back in the victory. The Orioles recorded nine hits in the game and they were led by Alonso, who went 1-4 with one home run and two RBIs. Baz allowed six hits and one earned run over 5.2 innings for the win, while Helsley got the save. Prior to this series, Baltimore lost two out of three against the Red Sox, but did win two out of three against the Royals before that. 

This season, Baltimore has a 4.28 ERA with a 1.40 WHIP and a .259 opponent batting average, while they have scored 130 runs with a .240 batting average and a .321 on base percentage. Gunnar Henderson has led the Orioles with nine home runs and 18 RBIs, while Jeremiah Jackson has added five home runs and 19 RBIs. The projected starting pitcher for Baltimore is Chris Bassitt, who is 1-2 with a 6.75 ERA and a 2.06 WHIP over 21.1 innings pitched this season. 

Why the Baltimore Orioles will win

• The Astros have lost seven of their last eight night games against American League opponents.
• The Orioles have won four of their last five night games against American League opponents that held a losing record.
• The Orioles have covered the run line in eight of their last nine night games against the Astros following a home win.
• The Astros have failed to cover the run line in each of their last four night games against American League opponents.
• The Astros have trailed after 3 innings in each of their last three games against American League opponents that held a losing record.
• The Orioles have won the first inning in three of their last four games against AL West opponents that held a losing record.
• The Orioles have led after 5 innings in three of their last four home games against AL West opponents that held a losing record.

Why the Houston Astros will win

• The Orioles have lost each of their last six games as home favorites against American League opponents following a home win.
• The Astros have won four of their last five games as road underdogs against AL East opponents following a loss.
• The Orioles have failed to cover the run line in each of their last six games as favorites against the Astros following a win.
• The Astros have covered the run line in 11 of their last 12 games as underdogs against the Orioles.
• The Orioles have trailed after 3 innings in each of their last five Wednesday night games against American League opponents that held a losing record.
• The Astros have led after 5 innings in three of their last four games as road underdogs.

Total Runs Facts

• Seven of the Orioles’ last eight games have gone OVER the total runs line.
• Seven of the Astros’ last eight games after playing the previous day have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last 15 games as underdogs against American League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Orioles’ last six Wednesday night games against AL West opponents.

Baltimore Orioles Player Prop Facts

• Pete Alonso has hit a home run in each of his last two home appearances against AL West opponents that held a losing record.
• Chris Bassitt has recorded five or more strikeouts in 13 of his last 14 home appearances against AL West opponents that held a losing record.
• Ryan Mountcastle has recorded at least one hit in each of his last 12 home appearances against the Astros.

Houston Astros Player Prop Facts

• Yordan Alvarez has hit a home run in four of his last six appearances in night games against AL East teams that held a losing record.
• Yainer Diaz has recorded at least one hit in each of his last nine road appearances against the Orioles.

Astros vs Orioles Prediction 

Baltimore was able to get the win to start this series, but they allowed quite a few baserunners in that game one victory. The Orioles are 8-8 at home this year, while the Astros are 3-11 on the road. Houston has dropped three of their last four games and they have allowed 29 runs during that span. The Astros are starting Lambert, who has allowed four earned runs and 10 hits over 11.0 innings, while Bassitt has allowed 4+ earned runs in three of his five starts. I am worried about Houston’s performance on the road, but I will back them to get the win here.

David Racey's Pick: Astros ML