Arizona Diamondbacks vs San Francisco Giants Prediction 5/25/2026 Today’s MLB Picks

The Arizona Diamondbacks and San Francisco Giants meet Monday in MLB action at Comerica Park. Here’s an Arizona Diamondbacks vs. San Francisco Giants Prediction. This article will include an Arizona Diamondbacks vs. San Francisco Giants Pick.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 28-24 on the year and play the Mariners and Dodgers next. The Arizona Diamondbacks are batting. 248 on the season, have a .313 OBP, and have a .404 slugging percentage. The Arizona Diamondbacks’ pitching staff has a 4.08 ERA and a 1.25 WHIP. Ildemaro Vargas leads the Arizona Diamondbacks with 55 hits and 32 RBI while Ketel Marte and Corbin Carroll have combined for 104 hits and 55 RBI.

Merrill Kelly gets the ball for the Arizona Diamondbacks, and he is 4-3 with a 5.71 ERA and 27 strikeouts this season. Kelly is 9-5 with a 3.30 ERA and 110 strikeouts in his career against the San Francisco Giants.

San Francisco Giants Betting Preview

The San Francisco Giants are 22-31 on the year and play the Brewers and Rockies next. The San Francisco Giants are batting. 247 on the season, have a .295 OBP, and have a .387 slugging percentage. The San Francisco Giants’ pitching staff has a 4.22 ERA and a 1.34 WHIP. Luis Arraez leads the San Francisco Giants with 63 hits and 18 RBI while Rafael Devers and Casey Schmitt have combined for 100 hits and 54 RBI.

Landen Roupp gets the ball for the San Francisco Giants, and he is 5-4 with a 3.27 ERA and 61 strikeouts this season. Roupp is 0-0 with a 3.45 ERA and 13 strikeouts in his career against the Arizona Diamondbacks.

Why the San Francisco Giants will win

• The Diamondbacks have lost seven of their last eight games at Oracle Park following a win.
• The favorites have won each of the Giants’ last six games at Oracle Park.
• The Giants have covered the run line in five of their last six home games against the Diamondbacks.
• The Diamondbacks have failed to cover the run line in four of their last five road games following a win.
• The Giants have led after 3 innings in five of their last six games as home favorites against NL West opponents.
• The Giants have led after 5 innings in three of their last four games as home favorites.

Why the Arizona Diamondbacks will win

• The Diamondbacks have won seven of their last eight games against teams that held a losing record.
• The Giants have lost each of their last five games against National League opponents.
• The Diamondbacks have covered the run line in each of their last six day games against National League opponents following a home win.
• The Giants have failed to cover the run line in each of their last five games against National League opponents.
• The Giants have trailed after 5 innings in three of their last four day games against NL West opponents.
• The Giants have lost the first inning in three of their last four games against National League opponents.
• The Giants have trailed after 3 innings in each of their last four games against National League opponents that held a winning record.

Total Runs Facts

• Seven of the Giants’ last eight home games against NL West opponents have gone UNDER the total runs line.
• Four of the Diamondbacks’ last five games as underdogs against National League opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Giants’ last nine games as favorites against NL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Diamondbacks’ last five games at Oracle Park.

San Francisco Giants Player Prop Facts

• Casey Schmitt has hit a home run in each of the Giants’ last three day games.
• Rafael Devers has recorded at least one hit in each of the Giants’ last 10 games as favorites against NL opponents.
• Luis Arraez ranks 4th amongst qualified players for Batting Average (.320) this season.

Arizona Diamondbacks Player Prop Facts

• Merrill Kelly has recorded a win in four of his last five appearances against NL West opponents that held a losing record.
• Merrill Kelly has recorded five or more strikeouts in 13 of his last 15 appearances in day games.
• Corbin Carroll has recorded at least one hit in each of his last 12 appearances.
• James McCann has hit a home run in three of his last eight appearances against the Giants.
• Ildemaro Vargas ranks 9th amongst qualified players for Batting Average (.307) this season.

Matchup/League Facts

• The Giants rank 29th in the league for runs scored this season (195).
• The Giants rank 29th in the league for RBIs this season (189).
• The Diamondbacks rank 2nd in the league for doubles this season (99).
• The Diamondbacks rank 3rd in the league for strikeouts against this season (392).

Arizona Diamondbacks vs San Francisco Giants Prediction

The Giants have the edge with Roupp on the mound, but the team overall has had issues stringing wins together. Even with the lesser pitcher in Kelly who has a 5.71 ERA and 1.51 WHIP, the Diamondbacks are coming off a hell of a week and it forces me to look toward the plus money. Also for what it’s worth Kelly has been better this month, allowing 23 hits and 11 runs in his last 26.1 innings. We’re getitng the more favorable price with the team in better form. Give it to me.

Randy Chambers's Pick: Arizona Diamondbacks