Arizona Diamondbacks vs San Diego Padres Prediction 9/26/2026 Today’s MLB Picks

The Arizona Diamondbacks and the San Diego Padres meet Saturday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Diamondbacks vs. San Diego Padres prediction.

Starting Pitching Matchup

The Arizona Diamondbacks did not have a starting pitcher announced at the time that this article was posted. The San Diego Padres will send out Walker Buehler for the Padres here and Buehler is 9-6 with a 4.56 ERA and 128 strikeouts.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to add on to their 11-4 win over the Padres on Friday to improve to 86-74 this season.

Diamondbacks Win 6 Straight

Geraldo Perdomo and Gabriel Moreno tie for the Diamondbacks’ team lead with 146 hits each, with Perdomo adding 20 doubles, 9 triples, 9 home runs, and 58 RBIs so far this season. Moreno has contributed 33 doubles, a triple, 16 home runs, and 82 RBIs while leading Arizona in batting average and on-base percentage. Corbin Carroll and Ketel Marte share 137 hits apiece, with Carroll logging 32 doubles, 17 triples, 22 home runs, and 76 RBIs, and Marte adding 30 doubles, 3 triples, 22 home runs, and 75 RBIs on the year. Nolan Arenado paces Arizona across the board in power, leading the team with 30 home runs and 85 RBIs alongside 134 hits, 24 doubles, and a triple. Ildemaro Vargas has chipped in 115 hits with 19 doubles, 5 triples, 9 home runs, and 67 RBIs up to this point in the season.

San Diego Padres Recap

The San Diego Padres come into this game looking to rebound from their loss to Arizona on Friday to fall to 89-71 this season.

Padres Split Last Four Games

Fernando Tatis Jr. leads the Padres with a team-high 181 hits while adding 32 doubles, 3 triples, 25 home runs, and 82 RBIs so far this season. Manny Machado paces San Diego in power, leading the team with 29 home runs and 87 RBIs alongside 125 hits and 22 doubles on the year. Jackson Merrill has contributed 154 hits with 26 doubles, 5 triples, 26 home runs, and 86 RBIs. Xander Bogaerts has logged 119 hits with 18 doubles, a triple, 12 home runs, and 56 RBIs, while Gavin Sheets has chipped in 75 hits with 15 doubles, 16 home runs, and 46 RBIs for the Padres up to this point in the season.

Arizona Diamondbacks @ San Diego Padres Betting Trends: September 26, 2026

• Probable Starting Pitcher: Walker Buehler      Record this season: 9-6      ERA: 4.56
• Home Record: 5-3
• Last 5 against Diamondbacks: 3-1

Why the San Diego Padres will win

• The Padres have won each of their last eight games against the Diamondbacks following a loss.
• The Diamondbacks have lost five of their last six night games at Petco Park following a win.
• The Padres have covered the run line in each of their last 10 games as favorites against NL West opponents following a loss.
• The Diamondbacks have failed to cover the run line in four of their last five games at Petco Park against teams that held a winning record.
• The Padres have led after 3 innings in four of their last five games as favorites against NL West opponents.
• The Padres have led after 5 innings in each of their last eight games as favorites against NL West opponents.

• Probable Starting Pitcher: TBD

Why the Arizona Diamondbacks will win

• The Diamondbacks have won seven of their last eight games as underdogs after playing the previous day.
• The Padres have lost five of their last six home games against NL West opponents that held a winning record.
• The Diamondbacks have covered the run line in 15 of their last 16 games as road underdogs against NL West opponents following a win.
• The Padres have failed to cover the run line in four of their last five home games against NL West opponents.
• The Diamondbacks have won the first inning in each of their last five games.
• The Diamondbacks have led after 3 innings in each of their last four games.
• The Diamondbacks have led after 5 innings in each of their last six games.

Total Runs Facts

• Each of the Padres’ last six home games have gone OVER the total runs line.
• Each of the Diamondbacks’ last four games as road underdogs have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of the Padres’ last eight games as favorites against NL West opponents.
• There has been at least one run scored in the first inning in each of the Diamondbacks’ last eight night games against NL West opponents.

San Diego Padres Player Prop Facts

• Fernando Tatis Jr. has hit a home run in each of the Padres’ last two games as favorites.
• Walker Buehler has recorded a win in six of his last eight appearances against the Diamondbacks.
• Walker Buehler has recorded four or more strikeouts in each of his last seven home appearances against the Diamondbacks.
• Jackson Merrill has recorded at least one hit in each of the Padres’ last 11 games as favorites.
• Fernando Tatis Jr. ranks 3rd in the league in Hits (181) this season.

Arizona Diamondbacks Player Prop Facts

• Nolan Arenado has hit a home run in four of the Diamondbacks’ last five games.
• Nolan Arenado has recorded at least one hit in each of the Diamondbacks’ last 11 games.
• Gabriel Moreno ranks 2nd amongst qualified players for Batting Average (.311) this season.

Matchup/League Facts

• The Padres rank T3rd in the league for steals this season (162).
• The Padres rank T23rd in the league for doubles this season (231).
• The Diamondbacks rank 1st in the league for triples this season (42).
• The Diamondbacks rank 29th in the league for strikeouts this season (1125).

 Arizona Diamondbacks vs. San Diego Padres Prediction

I’m on Arizona in this one. The Diamondbacks have all of the motivation here and while motivation isn’t everything, I think it’s a big thing here as the Diamondbacks are red hot and are not a team I’m looking to step in front of right now. Walker Buehler has been a profitable option for San Diego but I think Arizona keeps the ball rolling. Give me Arizona.

Chris Ruffolo's Pick: Arizona +115