Arizona Diamondbacks vs San Diego Padres Prediction 9/26/2025 Today’s MLB Picks

The Arizona Diamondbacks and San Diego Padres meet Friday in MLB action at Petco Park. Here’s a Arizona Diamondbacks vs San Diego Padres Prediction. This article will include a Arizona Diamondbacks vs San Diego Padres Pick.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 80-79 on the year after playing the Dodgers. The Arizona Diamondbacks are batting .251 on the season, have a .324 OBP, and a .433 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.43 ERA and a 1.31 WHIP. Geraldo Perdomo leads the Arizona Diamondbacks with 169 hits and 98 RBI while Corbin Carroll and Ketel Marte have combined for 280 hits and 154 RBI.

Zac Gallen gets the ball for the Arizona Diamondbacks, and he is 13-14 with a 4.70 ERA and 172 strikeouts this season. Gallen is 5-3 with a 3.12 ERA and 83 strikeouts in his career against the San Diego Padres.

San Diego Padres Betting Preview

The San Diego Padres are 87-72 on the year after playing the Brewers. The San Diego Padres are batting .252 on the season, have a .320 OBP, and a .388 slugging percentage. The San Diego Padres pitching staff has a 3.64 ERA and a 1.20 WHIP. Luis Arraez leads the San Diego Padres with 176 hits and 61 RBI while Manny Machado and Fernando Tatis Jr. have combined for 322 hits and 159 RBI.

Yu Darvish gets the ball for the San Diego Padres, and he is 4-5 with a 5.51 ERA and 64 strikeouts this season. Darvish is 9-5 with a 3.78 ERA and 145 strikeouts in his career against the Arizona Diamondbacks.

Arizona Diamondbacks @ San Diego Padres Betting Trends: September 26, 2025

• Probable Starting Pitcher: Yu Darvish      Record this season: 4-5      ERA: 5.51
• Home Record: 3-2
• Last 5 against Diamondbacks: 2-2

Why the San Diego Padres will win

• The Padres have won 12 of their last 13 home games against National League opponents following a home loss.
• The Diamondbacks have lost eight of their last nine Friday night games at Petco Park.
• The Padres have covered the run line in six of their last seven games as home favorites against NL West opponents.
• The Diamondbacks have failed to cover the run line in each of their last four games following a home loss.
• The Diamondbacks have trailed after 5 innings in four of their last five games against opponents that held a winning record.

• Probable Starting Pitcher: Zac Gallen      Record this season: 13-14      ERA: 4.70
• Road Record: 7-7
• Last 5 against Padres: 4-0

Why the Arizona Diamondbacks will win

• The underdogs have won seven of the last eight games between the Diamondbacks and Padres at Petco Park.
• The Padres have lost four of their last six games as home favorites following a loss.
• The underdogs have covered the run line in each of the last eight games between the Diamondbacks and Padres at Petco Park.
• The Padres have failed to cover the run line in four of their last five games as home favorites against the Diamondbacks following a loss.
• The Padres have trailed after 3 innings in three of their last four night games against NL West opponents that held a winning record.
• The Padres have trailed after 5 innings in each of their last five Friday night games as favorites.

Total Runs Facts

• Eight of the last 10 games between the Diamondbacks and Padres at Petco Park have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Padres’ last six night games against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Diamondbacks’ last six night games.

San Diego Padres Player Prop Facts

• Luis Arraez has recorded at least one hit in each of his last 10 appearances against NL opponents.
• Jackson Merrill has hit a home run in four of the Padres’ last five games against NL West opponents.

Arizona Diamondbacks Player Prop Facts

• Ildemaro Vargas has recorded at least one hit in each of his last eight appearances in night games against teams that held a winning record.
• James McCann has hit a home run in two of his last three appearances at Petco Park against NL West opponents that held a winning record.
• Corbin Carroll ranks 7th amongst qualified players for Slugging Percentage (.544) this season.

Matchup/League Facts

• The Padres rank 2nd in the league for runs allowed this season (612).
• The Padres rank 28th in the league for home runs this season (147).
• The Diamondbacks rank 4th in the league for runs scored this season (782).
• The Diamondbacks rank 4th in the league for slugging percentage this season (.433).

Arizona Diamondbacks vs San Diego Padres Prediction

Big series as both the Diamondbacks and Padres are fighting for their playoff lives. Darvish has been hittable this season with a 5.51 ERA, and he’s allowed 22 hits and 11 earned runs in his last 19.1 innings. Gallen has had a down year, but he’s been better lately, allowing 21 hits and 10 runs in his last 37.2 innings. This is the best Gallen has looked this season, and the Diamondbacks have won 4 of his last 5 starts. The Diamondbacks have the more trustworthy arm on the mound. Give me the road team to draw first blood.