Arizona Diamondbacks vs Minnesota Twins Prediction 9/12/2025 Today’s MLB Picks

In this article, we will formulate a Diamondbacks vs Twins Prediction for this MLB game on Friday, September 12th at the Target Field the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Minnesota Twins Preview

The Minnesota Twins have a 64-82 record this season and are sitting on the 4th place of the AL Central. The Twins have a 35-36 home record and are 69-68 in over/under. They are coming off a 3-4 road defeat by the Angels, and are 2-8 in their last 10 games. Over is 6-4 in their last 12 games and are playing the Yankees and the Guardians next.

The Twins have a .239 batting average this season, .312 OBP and .398 Slugging percentage. Minnesota’s pitching staff has a 4.60 ERA and 1.33 WHIP. Trevor Larnach leads the Twins with 119 hits, while Byron Buxton adds team-highs both in RBI, with 76, and in home runs, with 31. He is also the team’s best hitter with a .275 batting average.

Pablo Lopez (R) is the projected starter for the Twins, and he has a 5-4 record, 2.84 ERA and 1.08 WHIP.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 73-74 record this season and are sitting on the 4th place of the NL West. The Diamondbacks have a 34-40 road record and are 70-68 in over/under They are coming off a 5-11 road defeat by the Giants, and have back-to-back losses. Over is 3-1 in their last 4 games and are playing the Phillies and the Giants next.

The Diamondbacks have a .250 batting average this season, .323 OBP and .434 slugging percentage. Arizona’s pitching staff has a 4.47 ERA and 1.32 WHIP. Geraldo Perdomo leads the Diamondbacks with 153 hits, adding a team-high 93 RBI. He Is also the team’s best hitter with a .284 batting average, while Corbin Carroll leads the team in home runs with 29.

Brandon Pfaadt (R) is the projected starting pitcher for the Diamondbacks, and he has a 13-8 record, 5.18 ERA and 1.38 WHIP.

Arizona Diamondbacks @ Minnesota Twins Betting Trends: September 12, 2025

• Probable Starting Pitcher: Pablo Lopez      Record this season: 5-4      ERA: 2.84
• Home Record: 2-0
• Last 5 against Diamondbacks: 0-2

Why the Minnesota Twins will win

• The Twins have won each of their last eight home games against the Diamondbacks.
• The Diamondbacks have lost each of their last four road games against AL Central opponents.
• The Diamondbacks have failed to cover the run line in each of their last seven games against AL Central opponents.
• The Twins have covered the run line in each of their last four games against NL West opponents following a loss.
• The Diamondbacks have trailed after 5 innings in each of their last four road games against AL Central opponents.
• The Diamondbacks have trailed after 3 innings in three of their last four games against American League opponents that held a losing record.
• The Diamondbacks have lost the first inning in four of their last five night games against American League opponents that held a losing record.

• Probable Starting Pitcher: Brandon Pfaadt      Record this season: 13-8      ERA: 5.18
• Road Record: 4-5
• Last 5 against Twins: 0-0

Why the Arizona Diamondbacks will win

• The Twins have lost each of their last six games as favorites.
• The Diamondbacks have won seven of their last eight games as underdogs against American League opponents.
• The underdogs have covered the run line in each of the Twins’ last 10 games.
• The Twins have failed to cover the run line each of their last seven home games against teams that held a losing record.
• The Diamondbacks have won the first inning in five of their last six night games against opponents that held a losing record.
• The Diamondbacks have led after 5 innings in each of their last four games against American League opponents.
• The Diamondbacks have led after 3 innings in each of their last four games against American League opponents.

Total Runs Facts

• Seven of the Twins’ last eight home games have gone OVER the total runs line.
• Each of the Diamondbacks’ last four games as underdogs against the Twins have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the Twins’ last 10 home games against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Diamondbacks’ last six road games against AL Central opponents.

Minnesota Twins Player Prop Facts

• Pablo Lopez has recorded a win in seven of his last eight appearances against opponents that held a losing record.
• Pablo Lopez has recorded six or more strikeouts in nine of his last 10 home appearances against NL opponents.
• Trevor Larnach has recorded at least one hit in each of his last 10 home appearances.
• Ryan Jeffers has hit at least one home run in three of his last four appearances with the Twins as favorites against the Diamondbacks.
• Ryan Jeffers has recorded a Double in each of the Twins’ last three night games against NL West opponents that held a losing record.
• Byron Buxton ranks 4th amongst qualified players for Slugging Percentage (.568) this season.

Arizona Diamondbacks Player Prop Facts

• Brandon Pfaadt has recorded a win in three of his last four appearances against AL opponents that held a losing record.
• Brandon Pfaadt has recorded five or more strikeouts in five of his six previous appearances against AL opponents that held a losing record.
• Gabriel Moreno has recorded at least one hit in each of his last 11 appearances in night games against teams that held a losing record.
• Lourdes Gurriel Jr. has hit a home run in each of the Diamondbacks’ last two games as road underdogs against the Twins.
• Corbin Carroll ranks 6th amongst qualified players for Slugging Percentage (.547) this season.

Matchup/League Facts

• The Twins rank T3rd in the league for walks allowed this season (415).
• The Twins rank 28th in the league for opponent batting average this season (.260).
• The Diamondbacks rank T1st in the league for triples this season (35).
• The Diamondbacks rank 3rd in the league for RBIs this season (705).

Diamondbacks vs Twins Prediction

The Twins are 5-1 in their last 6 head-to-head meetings against the Diamondbacks, having won their last four meetings in Minnesota. Over is 4-1 in their last 5 meetings.

In this Diamondbacks vs Twins Prediction, the Twins are coming as -130 home favorites. I don’t trust either team in this spot, as the Twins are looking like they have given up on the season, while the Dbacks are putting Pfaadt on the mound, who has been shaky at best, and terrible on the road, with a 7.13 road ERA. Lopez look good in his first start after his injury, and the Twins have a slightly better bullpen. Take the better pitcher playing at home in this one, so take the Minnesota Twins on the moneyline.