Arizona Diamondbacks vs Colorado Rockies Prediction 9/22/2026 Today’s MLB Picks

The Arizona Diamondbacks and the Colorado Rockies meet Tuesday in MLB action from Coors Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Diamondbacks vs. Colorado Rockies prediction.

Starting Pitching Matchup

The Arizona Diamondbacks will send out Michael Soroka for the start here and Soroka is 8-5 with a 3.45 ERA and 101 strikeouts this season. Kyle Freeland will start for the Rockies and is 4-10 with a 6.38 ERA and 104 strikeouts this season. 

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to add on to their 8-4 win over the Yankees last time out to sit at 82-74 this season. After this series, the Diamondbacks will head on the road for a game against the San Diego Padres.

Diamondbacks Pick Up Back-To-Back Wins

Gabriel Moreno leads the Diamondbacks with a team-high 139 hits while adding 32 doubles, a triple, 15 home runs, and 75 RBIs so far this season. Geraldo Perdomo has added 138 hits with 19 doubles, 7 triples, 9 home runs, and 52 RBIs, while Corbin Carroll has logged 134 hits with 31 doubles, 16 triples, 22 home runs, and 72 RBIs on the year. Ketel Marte has contributed 134 hits with 29 doubles, 3 triples, 22 home runs, and 74 RBIs. Nolan Arenado leads Arizona across the board in home runs and RBIs with a team-high 27 home runs and 78 RBIs alongside 126 hits, 23 doubles, and a triple. Ildemaro Vargas has chipped in 113 hits with 19 doubles, 5 triples, 9 home runs, and 67 RBIs up to this point in the season.

Colorado Rockies Recap

The Colorado Rockies come into this game looking to bounce back from their 2-1 loss at the hands of the Seattle Mariners last time out to sit at 57-99 this season. After this series, the Rockies will head on the road for a series against the Chicago White Sox.

Rockies Lose 8 Of Last 10

TJ Rumfield leads the Rockies with a team-high 159 hits while adding 29 doubles, 3 triples, 15 home runs, and 70 RBIs so far this season. Jake McCarthy has added 156 hits with 30 doubles, 13 triples, 15 home runs, and a team-high 83 RBIs, while Hunter Goodman leads Colorado with 39 home runs alongside 121 hits, 19 doubles, 2 triples, and 82 RBIs on the year. Willi Castro has contributed 111 hits with 20 doubles, a triple, 15 home runs, and 56 RBIs, while Troy Johnston has logged 109 hits with 31 doubles, a triple, 4 home runs, and 50 RBIs. Ezequiel Tovar has chipped in 96 hits with 22 doubles, 11 home runs, and 42 RBIs for Colorado up to this point in the season.

Arizona Diamondbacks @ Colorado Rockies Betting Trends: September 22, 2026

• Probable Starting Pitcher: Kyle Freeland      Record this season: 4-10      ERA: 6.38
• Home Record: 3-3
• Last 5 against Diamondbacks: 1-3

Why the Colorado Rockies will win

• The Diamondbacks have lost each of their last seven night games following a home win.
• The underdogs have won four of the Diamondbacks’ last five games.
• The Rockies have covered the run line in each of their last eight night games at Coors Field following a loss.
• The Diamondbacks have failed to cover the run line in each of their last seven night games following a home win.
• The Diamondbacks have trailed after 3 innings in each of their last three games as favorites.
• The Diamondbacks have trailed after 5 innings in five of their last six night games against NL opponents.

• Probable Starting Pitcher: Michael Soroka      Record this season: 8-5      ERA: 3.45
• Road Record: 4-2
• Last 5 against Rockies: 1-2

Why the Arizona Diamondbacks will win

• The Rockies have lost 12 of their last 13 games against teams that held a winning record.
• The Diamondbacks have won four of their last five road games.
• The road team has covered the run line in six of the Diamondbacks’ last eight games.
• The Rockies have failed to cover the run line in six of their last eight night games against teams that held a winning record.
• The Rockies have trailed after 5 innings in each of their last 12 night games against opponents that held a winning record.
• The Diamondbacks have won the first inning in each of their last four games against the Rockies.
• The Diamondbacks have led after 3 innings in each of their last four night games against the Rockies.

Total Runs Facts

• Each of the Rockies’ last seven night games against NL opponents have gone OVER the total runs line.
• Each of the Diamondbacks’ last six road games have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of the Diamondbacks’ last six night games at Coors Field.
• There has been at least one run scored in the first inning in nine of the last 10 night games between the Diamondbacks and Rockies at Coors Field.

Colorado Rockies Player Prop Facts

• Mickey Moniak has hit at least one home run in 10 of his last 16 home appearances against opponents that held a winning record.
• Kyle Freeland has recorded four or more strikeouts in six of his last seven home appearances.
• TJ Rumfield has recorded at least one hit in each of his last 13 home appearances against NL West opponents.
• TJ Rumfield ranks 3rd amongst qualified players for On Base Percentage (.392) this season.

Arizona Diamondbacks Player Prop Facts

• Gabriel Moreno has hit a home run in three of the Diamondbacks’ last four games against opponents that held a losing record.
• Michael Soroka has recorded a win in each of his last four appearances with his team as a road favorite against NL West opponents.
• Michael Soroka has recorded seven or more strikeouts in three of his last four appearances with his team as a road favorite against NL West opponents.
• Ketel Marte has recorded two or more hits in seven of his last eight appearances against the Rockies.
• Gabriel Moreno ranks 4th amongst qualified players for Batting Average (.307) this season.

Matchup/League Facts

• The Rockies rank 1st in the league for triples this season (39).
• The Rockies rank 30th in the league for ERA this season (5.57).
• The Diamondbacks rank 2nd in the league for triples this season (38).
• The Diamondbacks rank 29th in the league for strikeouts this season (1094).

Arizona Diamondbacks vs. Colorado Rockies Prediction

I’m backing Arizona in this one. For my money, Soroka is still the ace or #2 in this Diamondbacks rotation and he has fantastic career numbers against the Rockies all from the last couple of seasons. I think this is a spot where the Diamondbacks, who are still mathematically alive, kick Colorado when they’re down and Arizona ends up with the win in this one.

Chris Ruffolo's Pick: Arizona -195