Los Angeles Angels vs Cleveland Guardians Prediction 5/30/25 MLB Picks

The Los Angeles Angels and the Cleveland Guardians meet Friday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Angels vs. Cleveland Guardians prediction.

Starting Pitching Matchup

The Los Angeles Angels will start Jose Soriano in this one, and Soriano is 3-5 with a 3.73 ERA and 47 strikeouts this season. In his career, Soriano is 1-2 with a 4.67 ERA and 20 strikeouts against the Guardians. The Cleveland Guardians will send out Luis Ortiz for the start here, and he is 2-5 with a 4.73 ERA and 59 strikeouts this season. This will be Ortiz’s second career start against the Angels.

Los Angeles Angels Recap

The Los Angeles Angels come into this game looking to bounce back from a 1-0 loss at the hands of the Yankees last time out to slip to 25-30 on the year. After this series, the Angels will head on the road for a series against the Boston Red Sox.

Angels Drop Fifth In A Row

Logan O’Hoppe has 44 hits, including 14 home runs and 30 RBIs, while Nolan Schanuel has 50 hits with 9 doubles, a triple, 3 home runs, and 14 RBIs. Luis Rengifo has 7 doubles with his 38 hits, and Taylor Ward also has 46 hits as well, while Mike Trout’s added 9 home runs and 18 RBIs so far this season. Jorge Soler also has 10 doubles, 7 home runs, and 21 RBIs, but also has 61 strikeouts so far this season. Kyren Paris has also chipped in 24 hits with a triple, 6 home runs, and 11 RBIs in addition to 7 stolen bases. Ward has also chipped in 11 doubles, 15 home runs, and 37 RBIs, but has a team-high 64 strikeouts, while Zach Neto has 10 doubles, 9 home runs, 20 RBIs, and 8 stolen bases.

Why the Los Angeles Angels will win

• The Angels have won each of their last seven games as road underdogs.
• The Guardians have lost four of their last five games as favorites against AL West opponents.
• The Angels have covered the run line in each of their last eight games as underdogs against the Guardians following a home loss.
• The Guardians have failed to cover the run line each of their last four games against teams that held a losing record.

Los Angeles Angels Player Prop Facts

• Logan O’Hoppe has hit at least one home run in each of the Angels’ last three games as road underdogs.
• Taylor Ward has recorded at least one RBI in each of the Angels’ last six road games.
• Logan O’Hoppe has recorded at least one Single in each of the Angels’ last six games against the Guardians.
• Zach Neto has scored at least one run in each of the Angels’ last seven road games.
• Zach Neto has recorded at least one hit in each of his last 11 road appearances against AL opponents.
• Anthony Rendon has recorded a Double in each of his four previous appearances against the Guardians after not playing the previous day.
• Taylor Ward ranks T6th in the league in Home Runs (15) this season.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to build on their 7-4 win over the Dodgers last time out to improve to 30-25 on the year. After this series, the Guardians will head on the road for a series against the New York Yankees.

Guardians Snap Three-Game Losing Streak

Steven Kwan leads the Guardians with 66 hits as part of a .311 batting average and 4 home runs, 12 doubles, and 19 RBIs. Kyle Manzardo has 36 hits with 6 doubles, 2 triples, 10 home runs, and a team-high 28 RBIs this year. Gabriel Arias has 10 doubles but also 55 strikeouts, and Manzardo has 54 strikeouts so far this season. Arias has also added 4 home runs and 22 RBIs, and Jose Ramirez has chipped in 9 home runs and 27 RBIs. Carlos Santana has also added 45 hits with 6 home runs and 28 RBIs this season.

Why the Cleveland Guardians will win

• The Guardians have won each of their last 17 games against the Angels at Progressive Field following a home win.
• The Angels have lost 16 of their last 17 night games against American League opponents that held a winning record.
• The Angels have failed to cover the run line in each of their last 11 road games against AL Central opponents.
• The Guardians have covered the run line in each of their last eight night games against the Angels at Progressive Field following a home win.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in three of the Guardians’ last four games as favorites.
• Carlos Santana has recorded at least one RBI in each of the Guardians’ last six Friday games.
• Jose Ramirez has scored at least one run in each of the Guardians’ last six home games.
• Steven Kwan has recorded at least one Single in each of his last eight appearances against AL opponents.
• Jose Ramirez has recorded at least one hit in each of the Guardians’ last 21 games.
• Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.
• Steven Kwan ranks 7th in the league in Hits (66) this season.

Total Runs Facts

• Each of the Angels’ last five games have gone UNDER the total runs line.
• Each of the Guardians’ last four home games have gone OVER the total runs line.

Los Angeles Angels vs. Cleveland Guardians Prediction

I’m on the Guardians in this one. The Angels’ run of form looks to have had its wings clipped as the Angels just can’t seem to buy much offense right now. The Guardians haven’t been the most efficient team, but I think they have the edge in the bullpen, and while I’m not president of the Luis Ortiz fan club, I think he’ll be good enough here. I’ll roll with the Guardians at home in this one.