St. Louis Cardinals vs Baltimore Orioles Prediction 5/27/25 MLB Picks

The St. Louis Cardinals and the Baltimore Orioles meet Tuesday in MLB action from Camden Yards. We will look at this from a betting perspective and determine the best bets for this game. Here’s a St. Louis Cardinals vs. Baltimore Orioles prediction.

Starting Pitching Matchup

The St. Louis Cardinals will send out Andre Pallante for the start here, and Pallante is 4-3 with a 4.18 ERA and 35 strikeouts this season. This will be Pallante’s first career start against the Orioles. Tomoyuki Sugano will get the start for the Orioles here, and Sugano is 4-3 with a 3.07 ERA and 32 strikeouts this season. This will be Sugano’s first career start against the Cardinals.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to bounce back from a 5-2 loss at the hands of the Orioles in Monday’s series opener to fall to 30-24 on the year. After this series, the Cardinals will head on the road for a series against the Texas Rangers.

Cardinals Have Three-Game Win Streak Snapped

Brendan Donovan has a team-high 66 hits along with 18 doubles, 3 home runs, and 22 RBIs, while Lars Nootbaar has 49 hits with 7 home runs, 25 RBIs, and 4 stolen bases. Nolan Arenado also has 44 hits with 10 doubles, 5 home runs, and 25 RBIs of his own, and Victor Scott II has 44 hits with 8 doubles, a triple, 19 RBIs, and a team-high 16 stolen bases. Willson Contreras has also chipped in 46 hits with 6 home runs and 28 RBIs of his own this season.

Why the St. Louis Cardinals will win

• The Orioles have lost each of their last seven night games against National League opponents following a win.
• The Cardinals have won each of their last four night games against teams that held a losing record.
• The Orioles have failed to cover the run line in eight of their last nine home games after playing the previous day.
• The Cardinals have covered the run line in seven of their last eight night games against teams that held a losing record.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in each of his last two road appearances.
• Brendan Donovan has recorded a Double in each of the Cardinals’ last four games as road favorites.
• Nolan Arenado has recorded at least one RBI in five of the Cardinals’ last six night games.
• Willson Contreras has scored a run in each of the Cardinals’ last five night games against opponents that held a losing record.
• Nolan Arenado has recorded at least one Single in 12 of his last 13 appearances against AL East opponents.
• Masyn Winn has recorded at least one hit in each of his last nine appearances in night games against AL teams that held a losing record.
• Brendan Donovan ranks 5th in the league in Hits (66) this season.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to build on their series-opening win over the Cardinals to improve to 19-34 on the year. After this series, the Orioles will take on the Chicago White Sox at home.

Orioles Win Three Straight Games

Cedric Mullins has 40 hits so far this season, as well as 9 doubles, 10 home runs, and 31 RBIs with 7 stolen bases and a .226 batting average, while Adley Rutschman has 37 hits with 7 doubles, 5 homers, and 15 RBIs. Jackson Holliday has 46 hits with 5 doubles, 2 triples, 6 homers, and 23 RBIs. Ryan Mountcastle has 39 hits with 10 doubles, 2 homers, and 15 RBIs, and Gunnar Henderson has a team-high 56 strikeouts as well this season. Ryan O’Hearn also chipped in 52 hits with 7 doubles and 8 home runs with 18 RBIs, and Heston Kjerstad added 4 homers and 15 RBIs.

Why the Baltimore Orioles will win

• The underdogs have won each of the Orioles’ last nine games at Oriole Park at Camden Yards.
• The Cardinals have lost each of their last seven games against AL East opponents.
• The underdogs have covered the run line in each of the Orioles’ last nine games at Oriole Park at Camden Yards.
• The Cardinals have failed to cover the run line in seven of their last eight games as road favorites against American League opponents.

Baltimore Orioles Player Prop Facts

• Dylan Carlson has hit a home run in each of the Orioles’ last two games as underdogs.
• Ramon Urias has recorded a Single in each of his last eight home appearances against NL opponents that held a winning record.
• Gunnar Henderson has recorded at least one hit in each of his last 11 home appearances against NL opponents that held a winning record.
• Tyler O’Neill has scored at least one run in six of his last seven appearances with his team as a home underdog against NL Central opponents.
• Gary Sanchez has recorded at least one RBI in four of his last five appearances in night games against NL Central teams that held a winning record.
• Ryan O’Hearn ranks 4th amongst qualified players for On Base Percentage (.426) this season.

Total Runs Facts

• Each of the Cardinals’ last six road games after playing the previous day have gone UNDER the total runs line.
• Eight of the Orioles’ last nine night games after playing the previous day have gone UNDER the total runs line.

St. Louis Cardinals vs. Baltimore Orioles Prediction

I’m on St. Louis here. I get the case to be made for Baltimore at home after taking it to the Cards in game one, but the thing here is that the Cardinals are still playing the better baseball, in my opinion, and I’m not the biggest backer of Sugano given the lack of strikeout potential in his game. I think the Cardinals get it done here, so give me St. Louis in a bounce-back.