Chicago White Sox vs New York Mets Prediction 5/27/25 MLB Picks

The Chicago White Sox are visiting the New York Mets on Tuesday, May 27th at the Citi Field in the second game of this series, with the Mets having a 1-0 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs New York Mets Prediction. We will examine:

The New York Mets’ recent form and player performance

The Chicago White Sox’s recent form and player performance

Recent betting trends and streaks involving the New York Mets

Recent betting trends and streaks involving the Chicago White Sox

Recent betting trends in games played between the Chicago White Sox vs New York Mets

A summary that ties it all together and produces a favorable betting outcome for the Chicago White Sox vs New York Mets game

New York Mets Preview

The New York Mets have a 33-21 record this season and are sitting in second place in the NL East. The Mets have a 20-6 home record and are 18-33 in over/under. They are coming off a 2-1 home victory over the White Sox, and are 4-1 in their last 5 games. Under is 9-2 in their last 11 games, and they are playing the Rockies and the Dodgers next.

The Mets have a .245 batting average this season, a .328 OBP, and a .402 slugging percentage. New York’s pitching staff has a 2.78 ERA and 1.24 WHIP.  Francisco Lindor leads the Mets with 58 hits, adding a team-high 10 home runs. Pete Alonso leads the team in RBI with 40 and in batting average with .291.

Tylor Megill (R) will take the mound for the Mets, and he has a 3-4 record, 3.56 ERA, and 1.35 WHIP. He has been much better at home with a 1.86 ERA across four home starts, and he is coming off a quality start against the Red Sox, where he gave up just one run in 4.2 innings pitched. This will be his first career start against the White Sox.  

Chicago White Sox Preview

The Chicago White Sox have a 17-37 record this season and are sitting in last place in the AL Central. The White Sox have a 5-22 road record and are 24-26 in over/under. They are coming off a 1-2 road defeat by the Mets and have back-to-back losses. They are playing the Orioles and the Tigers next.

The White Sox have a .220 batting average this season, a .291 OBP, and a .341 Slugging percentage. Chicago’s pitching staff has a 4.07 ERA and 1.37 WHIP. Lenyn Sosa leads the White Sox with 49 hits and a team-high .277 batting average. Miguel Vargas leads the team in RBI, with 23, and in home runs, with 7.

Jonathan Cannon (R) will take the mound for the White Sox, and he has a 2-5 record, 3.76 ERA, and 1.31 WHIP. He has been weaker on the road with a 4.76 ERA across five road starts, and he has given up at least two runs in five of his last six starts. In his only previous start against the Mets last season, he gave up 4 runs in 5 innings of work.

Why the New York Mets will win

• The White Sox have lost each of their last 11 night games against National League opponents that held a winning record.
• The Mets have won each of their last eight home games against American League opponents.
• The White Sox have failed to cover the run line in each of their last five road games against National League opponents following a road loss.
• The Mets have covered the run line in six of their last seven night games against AL Central opponents.
• The White Sox have trailed after 3 innings in each of their last four night games against NL East opponents that held a winning record.
• The Mets have led after 5 innings in seven of their last eight night games against the White Sox.

Why the Chicago White Sox will win

• The Mets have lost three of their last four games as favorites against American League opponents.
• The road team has won four of the last five games between the White Sox and Mets.
• The Mets have failed to cover the run line each of their last eight games against teams that held a losing record.
• The White Sox have covered the run line in each of their last six games.
• The White Sox have led after 3 innings in three of their last four night games against National League opponents.
• The Mets have trailed after 5 innings in each of their last five games against American League opponents that held a losing record.

Total Runs Facts

• Each of the Mets’ last six games as favorites against the White Sox have gone UNDER the total runs line.
• Ten of the White Sox’s last 11 games as underdogs against the Mets have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the White Sox’s last five night games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Mets’ last six games.

Matchup/League Facts

• The Mets rank 1st in the league for ERA this season (2.78).
• The Mets rank 1st in the league for home runs allowed this season (34).
• The White Sox rank 30th in the league for hits this season (385).
• The White Sox rank 29th in the league for batting average this season (.220).

Chicago White Sox vs New York Mets Prediction

The Mets are 9-1 in their last 10 meetings against the White Sox, and are 3-1 in their last 4 meetings in New York. Under is 10-1 in their last 11 meetings.

In this Chicago White Sox vs New York Mets Prediction, the Mets are coming as huge -270 home favorites. The Mets are rightfully favored, as they have a superior overall record this season and have been extremely strong at home, while the White Sox have been one of the weakest road teams in the league. The Mets also have the third-best bullpen ERA and have a better batting average, while the White Sox are weaker against righties. Megill is coming off a bounce-back performance, while Cannon was torched by the Mets last season, so everything points to an easy Mets win in this one. Take the New York Mets on the runline.