Pittsburgh Pirates vs Arizona Diamondbacks Prediction 5/27/25 MLB Picks

In this article, we will formulate a Pirates vs Diamondbacks prediction for this MLB game on Tuesday, May 27, at Chase Field in Phoenix, Arizona. Let’s take a look at the prediction for this MLB matchup.

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates (19-36, 6-20 Away) were in fine form with four wins in five games, but now lost back-to-back games to the Milwaukee Brewers and in the opening game of this series to the Arizona Diamondbacks. For the second time in ten days, the Pirates failed to score in a 5-0 defeat last night. Andrew Heaney took the loss after allowing five runs on eight hits with two strikeouts and three walks in 5.0 innings.

This year, the Pirates average 2.98 runs per game (30th in the MLB) on a .223/.303/.329 triple-slash. When it comes to pitching, the Pirates’ staff has a 4.03 ERA (19th) and 1.27 WHIP (17th). Bryan Reynolds leads the Pirates with a .208 batting average, six home runs, and 27 RBI this season.

The projected starting pitcher for the Pirates is Mike Burrows, who is 0-1 in one start this season, with a 7.20 ERA and 1.20 WHIP in 5.0 innings.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks (27-27, 14-13 Home) snapped a five-game losing skid with a Game 1 win over the Pittsburgh Pirates. That five-game losing run was Arizona’s longest of the season, during which the D-backs were swept by the Cardinals and lost a series to the Dodgers. In Monday’s 5-0 victory against Pittsburgh, Josh Naylor led the offense with two RBI, while Ryne Nelson had his best start of the season as he got the win, allowing no runs on four hits with four strikeouts and no walks across 6.2 innings of work.

This season, the Diamondbacks average 5.04 runs per game (5th in the MLB) on a .256/.333/.449 triple-slash. When it comes to pitching, the Diamondbacks’ staff has a 4.59 ERA (24th) and 1.31 WHIP (19th). Eugenio Suarez leads the Diamondbacks with a .232 batting average, 15 home runs, and 41 RBI this season.

Corbin Burnes will take the mound for the Diamondbacks on Tuesday. The 30-year-old right-hander has a 3-2 record in nine starts this year with a 2.73 ERA and 1.18 WHIP in 52.2 innings.

Why the Diamondbacks will cover

• The Pirates have lost 14 of their last 15 games against NL West opponents following a loss.
• The home team has won seven of the Diamondbacks’ last eight games.
• The Pirates have failed to cover the run line in eight of their last nine games against NL West opponents.
• The Diamondbacks have covered the run line in five of their last six games against National League opponents after playing the previous day.
• The Pirates have trailed after 3 innings in five of their last six games as road underdogs against NL West opponents.
• The Pirates have trailed after 5 innings in each of their last four road games against National League opponents.

Total Runs Facts

• Each of the Pirates’ last five road games after playing the previous day have gone UNDER the total runs line.
• Five of the Diamondbacks’ last six home games have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Diamondbacks’ last eight games as favorites against NL Central opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Pirates’ last six road games against NL West opponents.

Matchup/League Facts

• The Diamondbacks rank 4th in the league for strikeouts against this season (402).
• The Diamondbacks are one of only four teams in the league to rank top 10 in both strikeouts and on-base percentage this season.
• The Pirates rank 30th in the league for RBIs this season (159).
• The Pirates rank 30th in the league for slugging percentage this season (.329).

Pirates vs Diamondbacks Prediction

The Diamondbacks won seven of the previous ten H2H encounters, including three of the last four. I am backing the D-backs to win Game 2 with no trouble, as they will start their best pitcher, Corbin Burnes. Burnes allowed only five runs in his last five starts and recorded two shutouts in the process. He allowed a .169 BA in 118 at-bats against the Pirates in his career. In other words, he owns the Pirates. Mike Burrows, on the other hand, will get his second ever start in the MLB and his inexperience will prove costly against one of the best hitting teams in the league. Feel free to back Arizona to win and cover.