Seattle Mariners vs Houston Astros Prediction 5/23/25 MLB Picks

In this article, we will formulate a Mariners vs Astros prediction for this MLB game on Friday, May 23, at Daikin Park in Houston, Texas. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Betting Preview

The Seattle Mariners (28-21, 15-10 Away) are on a three-series road trip on which they swept the San Diego Padres and beat the Chicago White Sox. They opened the current one against the Houston Astros with a 9-2 defeat. George Kirby took the loss after allowing five runs on six hits with four strikeouts and one walk in 3.2 innings.

This year, the Mariners average 4.67 runs per game (9th in the MLB) on a .236/.325/.398 triple-slash. When it comes to pitching, the Mariners’ staff has a 3.74 ERA (13th) and 1.30 WHIP (19th). Cal Raleigh leads the Mariners with a .253 batting average, 16 home runs, and 33 RBI this season.

The projected starting pitcher for the Mariners is Emerson Hancock, who is 1-2 in seven starts this season, with a 6.21 ERA and 1.68 WHIP in 33.1 innings.

Houston Astros Betting Preview

The Houston Astros (26-24, 16-9 Home) returned home after playing against the Texas Rangers and Tampa Bay Rays on the road. The Astros split with the Rangers and lost the series to the Rays, and then opened the series against teh Mariners with a 9-2 victory. Jose Altuve led the offense with a pair of home runs and four RBI, while Lance McCullers Jr. pitched for 4.1 innings in a no-decision, allowing two runs on five hits with eight strikeouts and three walks. Shawn Dubin was credited with the win.

This season, the Astros average 4.08 runs per game (22nd in the MLB) on a .249/.320/.383 triple-slash. When it comes to pitching, the Astros’ staff has a 3.45 ERA (8th) and 1.14 WHIP (2nd). Isaac Paredes leads the Astros with a .264 batting average, ten home runs, and 29 RBI this season.

Ryan Gusto will take the mound for the Astros on Friday. The 26-year-old right-hander has a 3-2 record in five starts this year with a 4.65 ERA and 1.52 WHIP in 31.0 innings.

Total Runs Facts

• Each of the Mariners’ last four games as road underdogs have gone UNDER the total runs line.
• Nine of the Astros’ last 12 games as favorites against American League opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Astros’ last eight Friday night games at Daikin Park.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Mariners’ last four road games against AL West opponents.

Matchup/League Facts

• The Astros rank 28th in the league for steals this season (24).
• The Astros rank 4th in the league for strikeouts this season (460).
• The Mariners are one of only three teams in the league to rank top 10 in both steals and home runs this season.
• The Mariners rank T27th in the league for triples this season (2).

Mariners vs Astros Prediction

The teams have traded wins in the last couple of years, each recording five in the previous ten games. This season, they met four times, and each team secured two wins. The last two went Over, and I am going with Over in this one as well. Emerson Hancock and Ryan Gusto are surely not the best pitchers of their respective teams, and I expect both to struggle on Friday. I am backing Seattle and Houston to score 3+ runs off starters in the opening five innings. Go with Over.