Cleveland Guardians vs Detroit Tigers Prediction 5/23/25 MLB Picks

The Cleveland Guardians and the Detroit Tigers meet Friday in MLB action from Comerica Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs. Detroit Tigers prediction.

Starting Pitching Matchup

The Cleveland Guardians will start Slade Cecconi for the start here, and Cecconi is 0-1 with a 5.40 ERA and 8 strikeouts this season. This will be Cecconi’s first career start against the Tigers. Jackson Jobe will get the start for the Tigers here and is 4-0 with a 4.12 ERA and 32 strikeouts this season. This will be Jobe’s first career start against the Guardians.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to build on their series-opening 7-0 win over the Tigers from Thursday’s series opener to improve to 27-22 on the year. After this series, the Guardians will head home for an interleague series against the Los Angeles Dodgers.

Guardians Win Back-To-Back Games

Steven Kwan leads the Guardians with 61 hits as part of a .314 batting average and 4 home runs, 11 doubles, and 17 RBIs. Kyle Manzardo has 32 hits with 5 doubles, 2 triples, 10 home runs, and a team-high 26 RBIs this year. Gabriel Arias has 8 doubles but also 46 strikeouts, and Manzardo has 47 strikeouts so far this season. Arias has also added 4 home runs and 20 RBIs, and Jose Ramirez has chipped in 9 home runs and 24 RBIs. Carlos Santana has also added 38 hits with 6 home runs and 26 RBIs this season.

Why the Cleveland Guardians will win

• The Guardians have won each of their last 12 Friday games at Comerica Park.
• The Tigers have lost five of their last six games as favorites against American League opponents following a home loss.
• The Tigers have failed to cover the run line in each of their last eight games as favorites.
• The Guardians have covered the run line in each of their last six games as road underdogs against AL Central opponents.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit at least one home run in three of the Guardians’ last five road games against the Tigers.
• Carlos Santana has recorded at least one RBI in seven of the Guardians’ last eight road games.
• Jose Ramirez has scored a run in each of the Guardians’ last five games against AL Central opponents.
• Steven Kwan has recorded at least one Single in each of the Guardians’ last 10 road games against AL opponents that held a winning record.
• Jose Ramirez has recorded at least one hit in each of the Guardians’ last 15 games.
• Steven Kwan ranks T3rd in the league in Hits (61) this season.

Detroit Tigers Recap

The Detroit Tigers come into this game looking to bounce back from their shutout loss at the hands of the Guardians on Thursday to fall to 33-18 this season. After this series, the Tigers will welcome the San Francisco Giants to town for an interleague series.

Tigers Win 7 Of Their Last 10 Despite Series-Opening Loss

Spencer Torkelson has 43 hits along with a .244 batting average, including a team-high 12 home runs, 13 doubles, and 39 RBIs. Kerry Carpenter also has 10 home runs and 22 RBIs, while Riley Greene has 54 hits with 10 doubles, 12 home runs, and 34 RBIs, but also has a team-high 61 strikeouts this season. Dillon Dingler has 4 home runs and 18 RBIs, and Zack McKinstry’s added 9 doubles, 3 triples, 2 home runs, and 17 RBIs of his own, along with 44 hits this season. Javier Baez has added 42 hits and 8 doubles as well as 6 home runs and 29 RBIs this season.

Why the Detroit Tigers will win

• The Tigers have won seven of their last eight night games following a loss.
• The Guardians have lost three of their last four games after playing the previous day.
• The Tigers have covered the run line in 12 of their last 13 night games against AL Central opponents.
• The Guardians have failed to cover the run line in four of their last five road games against American League opponents following a win.

Detroit Tigers Player Prop Facts

• Riley Greene has hit a home run in three of the Tigers’ last five games as favorites.
• Kerry Carpenter has recorded at least one RBI in four of his five previous appearances with the Tigers as favorites against the Guardians.
• Kerry Carpenter has recorded at least one Single in each of the Tigers’ last seven games against AL Central opponents.
• Parker Meadows has recorded at least one hit in each of his last 13 appearances in night games.
• Matt Vierling has scored at least one run in each of his last six appearances with the Tigers as home favorites against AL Central opponents.
• Matt Vierling has recorded at least one Double in four of his last five appearances with the Tigers as favorites against the Guardians.
• Riley Greene ranks T9th in the league in Home Runs (12) this season.

Total Runs Facts

• Eight of the Guardians’ last nine night games after playing the previous day have gone UNDER the total runs line.
• Six of the Tigers’ last seven night games after playing the previous day have gone OVER the total runs line.

Cleveland Guardians vs. Detroit Tigers Prediction

I’m on the Tigers here. Cecconi wasn’t terrible in his debut, but the thing about Detroit this season has been that when they get knocked down, they don’t normally stay down, and the Tigers have also been outstanding at home this season. Jackson Jobe had some issues with control early on, but even when he was struggling, the Tigers would back him up accordingly at the plate. I think the Tigers bounce back here and get the job done, so give me Cleveland here.