Los Angeles Angels vs Oakland Athletics Prediction 5/21/25 MLB Picks

In this article, we will formulate an Angels vs Athletics prediction for this MLB game on Wednesday, May 21, at Sutter Health Park in Sacramento, California. Let’s take a look at the prediction for this MLB matchup.

Los Angeles Angels Betting Preview

The Los Angeles Angels (22-25, 13-15 Away) are experiencing their best stretch of the season after winning five games in a row. Following a series sweep of the Dodgers, the Angels beat the Athletics in the opening two games of the current series. In Tuesday’s 7-5 victory, Yoan Moncada led the offense with three RBI, while Kyle Hendricks got the win after allowing four runs on nine hits with three strikeouts and two walks across 5.2 innings of work.

This season, the Angels average 4.02 runs per game (21st in the MLB) on a .220/.281/.400 triple-slash. When it comes to pitching, the Angels’ staff has a 5.04 ERA (25th) and 1.49 WHIP (29th). Taylor Ward leads the Angels with a .203 batting average, 13 home runs, and 28 RBI this season.

Jack Kichanowicz will take the mound for the Angels on Wednesday. The 24-year-old right-hander has a 3-5 record in nine starts this year with a 4.71 ERA and 1.47 WHIP in 49.2 innings.

Athletics Betting Preview

The Athletics (22-26, 8-15 Home) are on a seven-game losing skid, their longest negative run of the season. The A’s lost four straight series to the Mariners, Yankees, Dodgers, and were swept by the Giants. Following a narrow 4-3 loss in Game 1 of the series against the Angels, the Athletics lost Game 2 as well, as it was 7-5 for Los Angeles. Nick Kurtz led the team with two RBI, while Gunnar Hoglund took the loss after allowing five runs on six hits with five strikeouts and two walks in 4.2 innings.

This year, the Athletics average 4.21 runs per game (17th in the MLB) on a .251/.313/.411 triple-slash. When it comes to pitching, the Athletics’ staff has a 5.10 ERA (26th) and 1.48 WHIP (27th). Tyler Soderstrom leads the Athletics with a .270 batting average, ten home runs, and 30 RBI this season.

The projected starting pitcher for the Athletics is JP Sears, who is 4-3 in nine starts this season, with a 3.31 ERA and 1.10 WHIP in 49.0 innings.

Total Runs Facts

• Five of the Athletics’ last six games as favorites have gone UNDER the total runs line.
• Six of the Angels’ last eight road games after playing the previous day have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Angels’ last seven road games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 14 of the Athletics’ last 17 home games against AL West opponents.

Matchup/League Facts

• The Athletics rank 28th in the league for runs allowed this season (271).
• The Athletics rank 5th in the league for strikeouts against this season (365).
• The Angels rank 29th in the league for steals this season (21).
• The Angels rank 29th in the league for strikeouts against this season (462).

Angels vs Athletics Prediction

The Athletics won six of the previous ten H2H encounters, but the Angels were better in the last three. Following a 12-run game on Tuesday, I am going with Under in this one. I expect no more than ten runs because of the starting pitchers. Kochanowicz was excellent in his last two starts, allowing just two runs against the Orioles and Dodgers, while JP Sears is the Athletics’ best pitcher, who allowed more than two runs only once in his previous six starts. Also, the Angels have a .193 BA in 238 at-bats against southpaws this season. I am backing both to have quality starts here. Go with the Under.