Arizona Diamondbacks vs Los Angeles Dodgers Prediction 5/21/25 MLB Picks

In this article, we will formulate a Diamondbacks vs Dodgers prediction for this MLB game on Wednesday, May 21, at Dodger Stadium in Los Angeles, California. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks (26-23, 13-10 Away) split the series with the Dodgers and then defeated the Giants and Rockies. The D-backs opened this series against the Dodgers with a 9-5 win, but fell short in extra innings in Game 2. In last night’s 4-3 defeat, Corbin Carroll led the offense with two RBI, while Ryne Nelson pitched for 5.0 innings in a no-decision, allowing one run on three hits with two strikeouts and one walk. Shelby Miller took the loss.

This year, the Diamondbacks average 5.25 runs per game (5th in the MLB) on a .256/.337/.452 triple-slash. When it comes to pitching, the Diamondbacks’ staff has a 4.71 ERA (24th) and 1.34 WHIP (21st). Eugenio Suarez leads the Diamondbacks with a .213 batting average, 14 home runs, and 38 RBI this season.

The projected starting pitcher for the Diamondbacks is Corbin Burnes, who is 3-1 in eight starts this season, with a 2.56 ERA and 1.25 WHIP in 45.2 innings.

Los Angeles Dodgers Betting Preview

The Los Angeles Dodgers (30-19, 18-8 Home) suffered their first sweep of the season after losing all three games of the series against the Angels at home. They lost four consecutive games for the first time this season after losing the opening game of this series against the Diamondbacks, but responded with a Game 2 4-3 win in extra innings. Will Smith led the team with two RBI, while Yoshinobu Yamamoto pitched for 7.0 innings in a no-decision, allowing no runs on one hit with nine strikeouts and two walks. Anthony Banda was credited with the win.

This season, the Dodgers average 5.77 runs per game (3rd in the MLB) on a .270/.345/.477 triple-slash. When it comes to pitching, the Dodgers’ staff has a 4.28 ERA (22nd) and 1.30 WHIP (18th). Teoscar Hernandez leads the Dodgers with a .306 batting average, nine home runs, and 35 RBI this season.

Dustin May will take the mound for the Dodgers on Wednesday. The 27-year-old right-hander has a 1-4 record in eight starts this year with a 4.43 ERA and 1.28 WHIP in 44.2 innings.

Why the Diamondbacks will beat the Dodgers

• The Diamondbacks have won each of their last 11 Wednesday road games.
• The Dodgers have lost four of their last five games as favorites.
• The Diamondbacks have covered the run line in each of their last seven games at Dodger Stadium.
• The Dodgers have failed to cover the run line in each of their last five games at Dodger Stadium.
• The Dodgers have trailed after 5 innings in four of their last five home games.
• The Dodgers have trailed after 3 innings in four of their last five home games.

Total Runs Facts

• Each of the Diamondbacks’ last six road games following an extra innings loss have gone OVER the total runs line.
• Six of the Dodgers’ last seven home games against National League opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Dodgers’ last seven games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 15 of the Diamondbacks’ last 18 road games against NL West opponents.

Matchup/League Facts

• The Dodgers rank 2nd in the league for runs scored this season (281).
• The Dodgers rank 2nd in the league for home runs this season (80).
• The Diamondbacks rank T3rd in the league for home runs this season (69).
• The Diamondbacks rank 3rd in the league for slugging percentage this season (.451).

Diamondbacks vs Dodgers Prediction

The Dodgers won six of the previous ten H2H encounters, but neither rival got two wins in a row over the past eight H2H duels. I am going with the D-backs in this one because of Corbin Burnes, who already got one win against the Dodgers this season. Burnes allowed no runs in 7.0 innings two weeks ago against Los Angeles, while Dustin May also started that game and took the loss, although he pitched well, allowing two runs in 6.2 innings. Burnes surrendered just two earned runs in his last four starts, and he registered two shutouts in his previous two starts. Back the D-backs to win.