Washington Nationals vs Baltimore Orioles Prediction 5/16/25 MLB Picks

The Washington Nationals and Baltimore Orioles meet Friday in MLB action at Oriole Park at Camden Yards. Here’s a Washington Nationals vs Baltimore Orioles Prediction. This article will include a Washington Nationals vs Baltimore Orioles Pick.

Washington Nationals Betting Preview

The Washington Nationals are 18-27 on the year and play the Braves, Giants, and Mariners next. The Washington Nationals are batting .238 on the season, have a .308 OBP, and a .377 slugging percentage. The Washington Nationals’ pitching staff has a 5.37 ERA and a 1.45 WHIP. James Wood leads the Washington Nationals with 46 hits and 25 RBI, while Keibert Ruiz and CJ Abrams have combined for 81 hits and 30 RBI. 

MacKenzie Gore gets the ball for the Washington Nationals, and he is 2-4 with a 3.59 ERA and 75 strikeouts this season. Gore is 0-2 with a 3.75 ERA and 15 strikeouts in his career against the Baltimore Orioles.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 15-27 on the year and play the Brewers, Red Sox, and Cardinals next. The Baltimore Orioles are batting .226 on the season, have a .295 OBP, and a .381 slugging percentage. The Baltimore Orioles pitching staff has a 5.34 ERA and a 1.48 WHIP. Gunnar Henderson leads the Baltimore Orioles with 38 hits and 12 RBI, while Ryan O’Hearn and Cedric Mullins have combined for 66 hits and 39 RBI.

Cade Povich gets the ball for the Baltimore Orioles, and he is 1-3 with a 5.55 ERA and 29 strikeouts this season. This will be Povich’s second career game against the Washington Nationals.

Why the Baltimore Orioles will win

• The Orioles have won seven of their last eight games at Oriole Park at Camden Yards against NL East opponents that held a losing record.
• The Nationals have lost each of their last four road games against American League opponents.
• The Nationals have failed to cover the run line in each of their last five road games against American League opponents after playing the previous day.
• The Orioles have covered the run line in each of their last four home games against the Nationals following a home loss.
• The Orioles have led after 5 innings in seven of their last eight games at Oriole Park at Camden Yards against NL East opponents that held a losing record.
• The Orioles have led after 3 innings in four of their last five night games against the Nationals at Oriole Park at Camden Yards.

Why the Washington Nationals will win

• The Orioles have lost five of their last six games as favorites against National League opponents.
• The underdogs have won four of the last five games between the Nationals and Orioles.
• The Orioles have failed to cover the run line in seven of their last eight home games.
• The road team has covered the run line in each of the Orioles’ last four games.
• The Nationals have led after 3 innings in five of their last six games against American League opponents.

Baltimore Orioles Player Prop Facts

• Cedric Mullins has hit a home run in two of the Orioles’ last three home games against opponents that held a losing record.
• Adley Rutschman has recorded an RBI in four of the Orioles’ last five home games against NL East opponents.
• Ramon Laureano has scored a run in four of his last five appearances in night games against NL East teams that held a losing record.
• Ramon Urias has recorded a Single in seven of his last eight appearances against NL East opponents at Oriole Park at Camden Yards.
• Ramon Laureano has recorded at least one hit in 18 of his last 19 appearances in night games against teams that held a losing record.
• Jordan Westburg has recorded at least one Double in six of his last eight home appearances against NL opponents that held a losing record.

Washington Nationals Player Prop Facts

• Josh Bell has hit a home run in three of his last four appearances against the Orioles after playing the previous day.
• Josh Bell has recorded at least one RBI in five of his last six appearances against the Orioles after playing the previous day.
• Nathaniel Lowe has scored at least one run in five of his last six appearances at Oriole Park at Camden Yards against AL East opponents that held a losing record.
• MacKenzie Gore has recorded eight or more strikeouts in four of his last five appearances in night games against teams that held a losing record.
• Nathaniel Lowe has recorded at least one hit in each of his last seven appearances at Oriole Park at Camden Yards against opponents that held a losing record.
• Amed Rosario has recorded at least one Single in each of his last six appearances with the Nationals as underdogs.
• James Wood ranks T8th in the league in Home Runs (11) this season.

Washington Nationals vs Baltimore Orioles Prediction

I keep saying the Orioles aren’t a good team, and they keep losing games. The Orioles have won six games since April 20. I’m just not excited to get behind the Orioles. I’m even less interested in Povich on the mound, a pitcher who has allowed 43 hits and 22 earned runs in 35.2 innings. In 17 home innings, Povich has a 7.94 ERA and a .300 allowed batting average. The Nationals aren’t playing any better, but they have the edge with Gore on the bump. Gore is first in strikeouts and has a top-40 WHIP at 1.16. Give me the Nationals and the more reasonable price with the better pitcher.