Seattle Mariners vs San Diego Padres Prediction 5/16/25 MLB Picks

In this article, we will formulate a Mariners vs Padres prediction for this MLB game on Friday, May 16, at PETCO Park in San Diego, California. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Betting Preview

The Seattle Mariners (23-19, 10-8 Away) beat the Athletics and then lost the series against the Blue Jays and Yankees. The loss to Toronto was surprising, considering the Blue Jays have swept the Mariners in Seattle. In the latest 3-2 defeat to the Yankees at home, Julio Rodriguez drove in both RBI for the offense, while Luis Castillo pitched for 6.0 innings in a no-decision, allowing one run on six hits with six strikeouts and two walks. Carlos Vargas took the loss.

This season, the Mariners average 4.79 runs per game (8th in the MLB) on a .239/.327/.399 triple-slash. When it comes to pitching, the Mariners’ staff has a 3.91 ERA (15th) and 1.33 WHIP (21st). Cal Raleigh leads the Mariners with a .248 batting average, 13 home runs, and 28 RBI this season.

Logan Evans will take the mound for the Mariners on Friday. The 23-year-old right-hander has a 1-1 record in three starts this year with a 6.60 ERA and 1.67 WHIP in 15.0 innings.

San Diego Padres Betting Preview

The San Diego Padres (27-15, 16-5 Home) were on a six-game winning streak before losing the series to the Yankees. The Padres did respond with wins over the Rockies and Angels. They opened a three-game series against the Angels with a loss, but won the next two games, including the most recent one, 5-1. Xander Bogaerts led the team with three RBI, while Randy Vasquez got the win after allowing one run on four hits with five strikeouts and one walk across 6.0 innings of work.

This year, the Padres average 4.67 runs per game (11th in the MLB) on a .264/.333/.400 triple-slash. When it comes to pitching, the Padres’ staff has a 3.30 ERA (5th) and 1.16 WHIP (4th). Fernando Tatis Jr. leads the Padres with a .308 batting average, 11 home runs, and 26 RBI this season.

The projected starting pitcher for the Padres is Stephen Kolek, who is 2-0 in two starts this season, with a 0.00 ERA and 0.91 WHIP in 14.1 innings.

Total Runs Facts

• Six of the Mariners’ last seven games against National League opponents have gone OVER the total runs line.
• Five of the Padres’ last six games as favorites have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Mariners’ last eight games as road underdogs.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Padres’ last six games.

Matchup/League Facts

• The Padres rank 2nd in the league for hits allowed this season (295).
• The Padres rank 2nd in the league for runs allowed this season (146).
• The Mariners rank 27th in the league for triples this season (2).
• The Mariners rank T26th in the league for doubles this season (56).

Mariners vs Padres Prediction

The Mariners won seven of the previous ten H2H encounters, including five of the last six. Seattle is 7-3 Over/Under in the last ten games, while San Diego is 6-4 Over/Under in that span. Stephen Kolek has been outstanding so far, and he even posted a complete game shutout against the Rockies in his previous start, but that was Colorado, the worst team in baseball. I believe the Mariners are going to hand him problems on Friday, and Kolek will surrender his first runs of the year. Logan Evans, on the other hand, allowed multiple runs in each of his three starts, and the rookie will face trouble against San Diego here. I am going with Over.